Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography

The aim of this study was to evaluate the feasibility of optical coherence tomography (OCT) to identify the components of vulnerable plaques in a well‐established murine model of human atherosclerosis.

[1]  M. Davies,et al.  Vulnerable plaque. Relation of characteristics to degree of stenosis in human coronary arteries. , 1996, Circulation.

[2]  Jason L Johnson,et al.  Characteristics of Intact and Ruptured Atherosclerotic Plaques in Brachiocephalic Arteries of Apolipoprotein E Knockout Mice , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[3]  G. Angelini,et al.  Plaque Rupture After Short Periods of Fat Feeding in the Apolipoprotein E–Knockout Mouse: Model Characterization and Effects of Pravastatin Treatment , 2005, Circulation.

[4]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[5]  E. Halpern,et al.  Characterization of Human Atherosclerosis by Optical Coherence Tomography , 2002, Circulation.

[6]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[7]  B E Bouma,et al.  High resolution in vivo intra-arterial imaging with optical coherence tomography , 1999, Heart.

[8]  K. Seung,et al.  Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. , 2002, Journal of the American College of Cardiology.

[9]  E. Halpern,et al.  Quantification of Macrophage Content in Atherosclerotic Plaques by Optical Coherence Tomography , 2003, Circulation.

[10]  M J Davies,et al.  Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. , 1985, British heart journal.

[11]  E. Rubin,et al.  Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.

[12]  Jason L. Johnson,et al.  Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. , 2001, Atherosclerosis.

[13]  M. Davies,et al.  Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. , 1993, British heart journal.

[14]  Thomas E. Milner,et al.  Use of a Blood Substitute to Determine Instantaneous Murine Right Ventricular Thickening With Optical Coherence Tomography , 2002, Circulation.

[15]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[16]  M J Davies,et al.  Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. , 1984, The New England journal of medicine.

[17]  R. Virmani,et al.  Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[18]  N. Maeda,et al.  Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. , 1992, Science.

[19]  J. Fujimoto,et al.  Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. , 1996, Circulation.

[20]  M. Reidy,et al.  A quantitative study of the preparation of rabbit aortic endothelial cells for scanning electron microscopy , 1980, Journal of microscopy.

[21]  Brett E. Bouma,et al.  In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography , 2005, Circulation.

[22]  S. Yun,et al.  In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. , 2004, Optics express.

[23]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[24]  Wolfgang Drexler,et al.  High resolution in vivo intra-arterial imaging with optical coherence tomography , 1999, Photonics West - Biomedical Optics.

[25]  Teresa C. Chen,et al.  Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography. , 2004, Optics express.

[26]  R A Wilson,et al.  Detection and characterization of vascular lesions by intravascular ultrasound: an in vitro study correlated with histology. , 1992, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[27]  S. Fazio,et al.  Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E. , 1993, The Journal of clinical investigation.

[28]  V. Fuster,et al.  Coronary plaque disruption. , 1995, Circulation.

[29]  R. Ross,et al.  ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.