[Recurrence occurring ten years after the initial diagnosis of granulosa cell tumour of the ovary: about two cases and review of the literatur].

Granulosa Cell Tumors (GCT) of the ovary are rare tumors belonging to the group of sex cord stromal tumors. They represent 0.6 - 3% of all ovarian tumors and 5% of all malignant tumors. Two different types of GCT can be distinguished: juvenile granulosa cell tumor (JGT) which is characterized by its aggressive potential and adult granulosa cell tumor (AGT) which is the most common and the least aggressive type. GCT of the ovary usually develops recurrences within 5 years of initial diagnosis but they rarely develop local or peritoneal metastases. Although treatment options including surgery with or without chemotherapy or radiation have been reported in treating GCT relapses, there are no standardized protocols for the treatment of relapses. We here present our therapeutic strategy in the treatment of longterm relapses of GCT peritoneal carcinomatosis occurring in two patients 10 years after the initial diagnosis and a review of the literature.

[1]  Mu‐Hsien Yu,et al.  A long-term follow-up study of 176 cases with adult-type ovarian granulosa cell tumors. , 2012, Gynecologic oncology.

[2]  Yong-Man Kim,et al.  Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. , 2012, Gynecologic oncology.

[3]  G. Freyer,et al.  Tumeur à cellules de la granulosa : revue de la littérature , 2000 .

[4]  M. Hirakawa,et al.  Successful treatment of adult‐type granulosa cell tumor of the ovary by palliative radiotherapy , 2012, The journal of obstetrics and gynaecology research.

[5]  B. Rosen,et al.  Role of adjuvant radiotherapy in granulosa cell tumors of the ovary. , 2011, International journal of radiation oncology, biology, physics.

[6]  I. Treilleux,et al.  [Rare ovarian tumours: therapeutic strategies in 2010, national website observatory for rare ovarian cancers and delineation of referent centers in France]. , 2010, Bulletin du cancer.

[7]  A. Rojo,et al.  Recurrencia tardía del tumor de células de la granulosa: presentación de un caso , 2012 .

[8]  Y. Yonemura,et al.  Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. , 2012, Gan to kagaku ryoho. Cancer & chemotherapy.

[9]  H. Fox Sex cord‐stromal tumours of the ovary , 1985, The Journal of pathology.

[10]  A. Petersen,et al.  Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. , 2001, Gynecologic oncology.

[11]  S. Bhargava,et al.  Ovarian sex cord stromal tumors: an institutional experience , 2017 .

[12]  K. Chao,et al.  Granulosa cell tumor of the ovary. , 1990, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.

[13]  L. H. Dutra GRANULOSA CELL TUMORS OF THE OVARY , 1947 .

[14]  Liang-Che Chang,et al.  A late recurring and easily forgotten tumor: ovarian granulosa cell tumor , 2012, World Journal of Surgical Oncology.