Clinical and radiological description of 120 pediatric stroke‐like episodes

Stroke‐like episodes (SLEs) are defined as acute onset of neurological symptoms mimicking a stroke and radiological lesions non‐congruent to vascular territory. We aimed to analyze the acute clinical and radiological features of SLEs to determine their pathophysiology.

[1]  Robert W. Taylor,et al.  Forecasting stroke-like episodes and outcomes in mitochondrial disease , 2021, Brain : a journal of neurology.

[2]  Liqin Yang,et al.  Reversible Dilation of Cerebral Macrovascular Changes in MELAS Episodes , 2019, Clinical Neuroradiology.

[3]  D. Geng,et al.  Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases , 2018, Journal of computer assisted tomography.

[4]  Anita Burgun-Parenthoine,et al.  A clinician friendly data warehouse oriented toward narrative reports: Dr. Warehouse , 2018, J. Biomed. Informatics.

[5]  A. Gropman,et al.  Cortical venous disease severity in MELAS syndrome correlates with brain lesion development , 2017, Neuroradiology.

[6]  Lin Ma,et al.  Differential diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke‐like episodes (MELAS) and ischemic stroke using 3D pseudocontinuous arterial spin labeling , 2017, Journal of magnetic resonance imaging : JMRI.

[7]  K. Yeom,et al.  Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood , 2016, American Journal of Neuroradiology.

[8]  N. Lax,et al.  Review: Central nervous system involvement in mitochondrial disease , 2016, Neuropathology and applied neurobiology.

[9]  A. Rabinstein,et al.  Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions , 2015, The Lancet Neurology.

[10]  S. Rahman.  Pathophysiology of mitochondrial disease causing epilepsy and status epilepticus , 2015, Epilepsy & Behavior.

[11]  M. Forsting,et al.  Posterior Reversible Encephalopathy Syndrome: The Spectrum of MR Imaging Patterns , 2015, Clinical Neuroradiology.

[12]  D. Altınok,et al.  Ornithine Transcarbamylase Deficiency Presenting With Acute Reversible Cortical Blindness , 2015, Journal of child neurology.

[13]  A. Gropman,et al.  Phenotypic Analysis of Epilepsy in the Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes–Associated Mitochondrial DNA A3243G Mutation , 2014, Journal of child neurology.

[14]  N. Boddaert,et al.  Hemiconvulsion–hemiplegia syndrome revisited: longitudinal MRI findings in 10 children , 2013, Developmental medicine and child neurology.

[15]  H. Urbach,et al.  Neuroimaging characteristics in mitochondrial encephalopathies associated with the m.3243A>G MTTL1 mutation , 2013, Journal of Neurology.

[16]  J. Hamada,et al.  Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2 , 2014, Journal of Neurology, Neurosurgery & Psychiatry.

[17]  L. Bindoff,et al.  Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects. , 2012, Brain : a journal of neurology.

[18]  P. Gressens,et al.  Hemiconvulsion-hemiplegia-epilepsy syndrome: current understandings. , 2012, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[19]  D. Attwell,et al.  Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[20]  Robert W. Taylor,et al.  Microangiopathy in the cerebellum of patients with mitochondrial DNA disease , 2012, Brain : a journal of neurology.

[21]  S. Rahman.  Mitochondrial disease and epilepsy , 2012, Developmental medicine and child neurology.

[22]  M. Russell,et al.  Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management , 2011, The Lancet Neurology.

[23]  H. Eo,et al.  Diffusion and Perfusion Characteristics of MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episode) in Thirteen Patients , 2011, Korean journal of radiology.

[24]  F. Woermann,et al.  Functional neuroimaging in the postictal state , 2010, Epilepsy & Behavior.

[25]  U. Stephani,et al.  Increased brain lactate during stroke-like episode in a patient with congenital disorder of glycosylation type Ia , 2009, Brain and Development.

[26]  E. Naito,et al.  Serial brain imaging analysis of stroke-like episodes in MELAS , 2008, Brain and Development.

[27]  A. Gropman,et al.  Neurological implications of urea cycle disorders , 2007, Journal of Inherited Metabolic Disease.

[28]  T. Degrauw,et al.  Radiologic and Neurophysiologic Aspects of Stroke-like Episodes in Children With Congenital Disorder of Glycosylation Type Ia , 2007, Pediatrics.

[29]  D. Turnbull,et al.  Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement , 2006, Neuropathology and applied neurobiology.

[30]  G. Rosati,et al.  “Erratic” complex partial status epilepticus as a presenting feature of MELAS , 2006, Epilepsy & Behavior.

[31]  K. Abe.  Cerebral lactic acidosis correlates with neurological impairment in MELAS , 2004, Neurology.

[32]  M. Dichgans,et al.  Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants , 2004, Neurology.

[33]  J. Olesen,et al.  Evidence for a separate type of migraine with aura , 2003, Neurology.

[34]  M. Fukuda,et al.  Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome , 2002, Neurology.

[35]  C E Elger,et al.  Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy , 2000, Annals of neurology.

[36]  S. Nakamura,et al.  Serial diffusion-weighted imaging in MELAS , 2000, Neuroradiology.

[37]  M. Maeda,et al.  Vasogenic edema on MELAS: A serial study with diffusion-weighted MR imaging , 1999, Neurology.

[38]  T. Yasuda,et al.  Periodic lateralized epileptiform discharges in mitochondrial encephalomyopathy. , 1997, Electroencephalography and clinical neurophysiology.

[39]  S. Pavlakis,et al.  Topical Review: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes (MELAS): Current Concepts , 1994, Journal of child neurology.

[40]  I. Nonaka,et al.  Strongly succinate dehydrogenase–reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes , 1991, Annals of neurology.

[41]  S. Dimauro,et al.  Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndrome , 1984, Annals of neurology.

[42]  L. Bindoff,et al.  No evidence of ischemia in stroke-like lesions of mitochondrial POLG encephalopathy. , 2017, Mitochondrion.

[43]  L. TomásMesa,et al.  Encefalomiopatia mitocondrial, acidosis lactica y apariencia de accidentes vasculares cerebrales , 1990 .

[44]  M. Endres,et al.  The clinical and radiological spectrum of posterior reversible encephalopathy syndrome: the retrospective Berlin PRES study , 2011, Journal of Neurology.

[45]  J. Salas-Puig,et al.  [Characteristics of status epilepticus in MELAS. Analysis of four cases]. , 2006, Neurologia.

[46]  R. Todd.  The Lumleian Lectures for 1849. On the pathology and treatment of convulsive diseases. , 2005, Epilepsia.

[47]  F. Sakai,et al.  Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. , 2005, Current neurovascular research.

[48]  B. Lach,et al.  Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy , 2004, Acta Neuropathologica.