Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

[1]  Howard Cedar,et al.  Epigenetics of haematopoietic cell development , 2011, Nature Reviews Immunology.

[2]  Keji Zhao,et al.  Application of ChIP-Seq and related techniques to the study of immune function. , 2011, Immunity.

[3]  J. O’Shea,et al.  Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 , 2011, Nature Immunology.

[4]  S. Desiderio,et al.  Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. , 2011, Immunity.

[5]  D. Reinberg,et al.  The Polycomb complex PRC2 and its mark in life , 2011, Nature.

[6]  M. Schlissel,et al.  Allelic exclusion of immunoglobulin genes: models and mechanisms , 2010, Immunological reviews.

[7]  Trey Ideker,et al.  A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates the B cell fate , 2010, Nature Immunology.

[8]  David G. Schatz,et al.  The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci , 2010, Cell.

[9]  A. Strasser,et al.  Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development , 2010, Nature Immunology.

[10]  B. Garcia,et al.  In Vivo Residue-specific Histone Methylation Dynamics* , 2009, The Journal of Biological Chemistry.

[11]  C. Murre,et al.  Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci , 2009, The Journal of experimental medicine.

[12]  Harinder Singh,et al.  Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development , 2009, Nature Immunology.

[13]  M. Reth,et al.  Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling , 2009, Nature Reviews Immunology.

[14]  Nathaniel D. Heintzman,et al.  Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.

[15]  A. Feeney,et al.  The Epigenetic Profile of Ig Genes Is Dynamically Regulated during B Cell Differentiation and Is Modulated by Pre-B Cell Receptor Signaling1 , 2009, The Journal of Immunology.

[16]  Yan Zhou,et al.  Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development , 2009, Proceedings of the National Academy of Sciences.

[17]  R. DePinho,et al.  SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway , 2008, Nature Immunology.

[18]  L. Kenner,et al.  The different functions of Stat5 and chromatin alteration through Stat5 proteins. , 2008, Frontiers in bioscience : a journal and virtual library.

[19]  T. Hashimshony,et al.  Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. , 2008, Immunity.

[20]  S. Desiderio,et al.  A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. , 2007, Immunity.

[21]  R. Hendriks,et al.  Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. , 2007, Immunity.

[22]  J. Imler,et al.  Dicing with viruses: microRNAs as antiviral factors. , 2007, Immunity.

[23]  Koon-Guan Lee,et al.  Combined deficiencies in Bruton tyrosine kinase and phospholipase Cgamma2 arrest B-cell development at a pre-BCR+ stage. , 2007, Blood.

[24]  R. Lu,et al.  IFN Regulatory Factor 4 and 8 Promote Ig Light Chain κ Locus Activation in Pre-B Cell Development1 , 2006, The Journal of Immunology.

[25]  D. Baltimore,et al.  Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716. , 2006, Journal of immunology.

[26]  P. Sicinski,et al.  A unique function for cyclin D3 in early B cell development , 2006, Nature Immunology.

[27]  Yuan Zhuang,et al.  E2A and IRF-4/Pip Promote Chromatin Modification and Transcription of the Immunoglobulin κ Locus in Pre-B Cells , 2006, Molecular and Cellular Biology.

[28]  J. Ihle,et al.  Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5 , 2005, Nature Immunology.

[29]  I. Mårtensson,et al.  Both the pre‐BCR and the IL‐7Rα are essential for expansion at the pre‐BII cell stage in vivo , 2005, European journal of immunology.

[30]  Yang Xu,et al.  Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating Vκ Jκ Rearrangement , 2004, The Journal of experimental medicine.

[31]  M. Schlissel,et al.  Regulation of activation and recombination of the murine Igκ locus , 2004 .

[32]  Takashi Nagasawa,et al.  Cellular niches controlling B lymphocyte behavior within bone marrow during development. , 2004, Immunity.

[33]  C. Murre,et al.  Receptor Editing and Marginal Zone B Cell Development Are Regulated by the Helix-Loop-Helix Protein, E2A , 2004, The Journal of experimental medicine.

[34]  Harinder Singh,et al.  IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. , 2003, Genes & development.

[35]  B. Chait,et al.  Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement , 2003, Nature Immunology.

[36]  M. Nussenzweig,et al.  B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-β1 , 2002, The Journal of Immunology.

[37]  I. Mårtensson,et al.  VpreB1/VpreB2/λ5 Triple-Deficient Mice Show Impaired B Cell Development but Functional Allelic Exclusion of the IgH Locus1 , 2002, The Journal of Immunology.

[38]  F. Alt,et al.  Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation , 2002, Nature Immunology.

[39]  H. Fleming,et al.  Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. , 2001, Immunity.

[40]  S. Spicuglia,et al.  TCRα enhancer activation occurs via a conformational change of a pre‐assembled nucleo‐protein complex , 2000, The EMBO journal.

[41]  A. Feeney,et al.  E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. , 2000, Molecular cell.

[42]  S. Moro,et al.  DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites , 2000, Molecular and Cellular Biology.

[43]  M. Schlissel,et al.  Accessibility and the developmental regulation of V(D)J recombination. , 1997, Seminars in immunology.

[44]  B. Groner,et al.  Functional interactions between Stat5 and the glucocorticoid receptor , 1996, Nature.

[45]  F. Alt,et al.  The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes , 1996 .

[46]  F. Alt,et al.  Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement , 1996 .

[47]  Ian Krop,et al.  E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements , 1994, Cell.

[48]  W. Uttal.  On models and mechanisms , 1992, Behavioral and Brain Sciences.

[49]  F. Alt,et al.  Development of the primary antibody repertoire. , 1987, Science.

[50]  David Baltimore,et al.  Multiple nuclear factors interact with the immunoglobulin enhancer sequences , 1986, Cell.

[51]  I. Aifantis,et al.  The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms. , 2005, Current topics in microbiology and immunology.

[52]  E. Wagner,et al.  Stat5 tetramer formation is associated with leukemogenesis. , 2005, Cancer cell.

[53]  M. Reth,et al.  The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion , 2003, Nature Immunology.