Unique and unprecedented recombination mechanisms in class switching.

[1]  J. Stavnezer,et al.  Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes. , 1999, Journal of immunology.

[2]  R. Kucherlapati,et al.  Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes , 1999, The Journal of experimental medicine.

[3]  T. Honjo,et al.  Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells* , 1999, The Journal of Biological Chemistry.

[4]  M. Neuberger,et al.  Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class‐switch recombination: parallels with somatic hypermutation , 1999, The EMBO journal.

[5]  F. Alt,et al.  Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Kevin A. Jarrell,et al.  Flipping the Switch to an Active Spliceosome , 1999, Cell.

[7]  Andreas Radbruch,et al.  Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination , 1998, The Journal of experimental medicine.

[8]  T. Honjo,et al.  Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. , 1998, Immunity.

[9]  F. Alt,et al.  Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers , 1998, The Journal of experimental medicine.

[10]  R. Jessberger,et al.  A B-cell-specific DNA Recombination Complex* , 1998, The Journal of Biological Chemistry.

[11]  F. Alt,et al.  Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching , 1998, The Journal of experimental medicine.

[12]  Heikyung Suh,et al.  Ku80 is required for immunoglobulin isotype switching , 1998, The EMBO journal.

[13]  Tasuku Honjo,et al.  Frequent but biased class switch recombination in the Sμ flanking regions , 1998, Current Biology.

[14]  J. Strouboulis,et al.  The effect of distance on long-range chromatin interactions. , 1997, Molecular cell.

[15]  A. Kenter,et al.  Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination. , 1997, Journal of immunology.

[16]  L. Du Pasquier,et al.  Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals , 1997, European journal of immunology.

[17]  K. Marcu,et al.  Antibody class switch recombinase activity is B cell stage specific and functions stochastically in the absence of 'targeted accessibility' control. , 1997, International immunology.

[18]  C. Snapper,et al.  The immunoglobulin class switch: beyond "accessibility". , 1997, Immunity.

[19]  N. Maizels,et al.  Developmental specificity of immunoglobulin heavy chain switch region recombination activities. , 1997, Molecular immunology.

[20]  A. Rolink,et al.  The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching , 1996 .

[21]  H. Arakawa,et al.  Chicken immunoglobulin μ-chain gene: germline organization and tandem repeats characteristic of class switch recombination , 1996 .

[22]  T. Honjo,et al.  High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. , 1996, International immunology.

[23]  R. Aguilera,et al.  Characterization of an endonuclease activity which preferentially cleaves the G-rich immunoglobulin switch repeat sequences. , 1996, Molecular immunology.

[24]  M. Lieber,et al.  Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[25]  R. Aguilera,et al.  The murine nucleolin protein is an inducible DNA and ATP binding protein which is readily detected in nuclear extracts of lipopolysaccharide-treated splenocytes. , 1995, Experimental cell research.

[26]  Andreas Radbruch,et al.  Switch transcripts in immunoglobulin class switching. , 1995, Science.

[27]  R. Kumar,et al.  Extrachromosomal eukaryotic DNA substrates for switch recombination: analysis of isotype and cell specificity. , 1994, DNA and cell biology.

[28]  L. Madisen,et al.  Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. , 1994, Genes & development.

[29]  F. Alt,et al.  A class switch control region at the 3′ end of the immunoglobulin heavy chain locus , 1994, Cell.

[30]  F. Alt,et al.  S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. , 1994, The EMBO journal.

[31]  K. Rajewsky,et al.  Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting , 1993, Cell.

[32]  A Shimizu,et al.  Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences. , 1993, Nucleic acids research.

[33]  F. Alt,et al.  Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[34]  K. Rajewsky,et al.  Shutdown of class switch recombination by deletion of a switch region control element , 1993, Science.

[35]  G. Hertz,et al.  DNA sequences at immunoglobulin switch region recombination sites. , 1993, Nucleic acids research.

[36]  N. Maizels,et al.  Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[37]  A. Kenter,et al.  Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells , 1990, Molecular and cellular biology.

[38]  J. Stavnezer,et al.  A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation , 1989, Molecular and cellular biology.

[39]  F. Alt,et al.  Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre‐B cells. , 1987, The EMBO journal.

[40]  F. Alt,et al.  Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. , 1986, The EMBO journal.

[41]  S. Sirlin,et al.  Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. , 1986, The EMBO journal.

[42]  T. Honjo,et al.  Immunoglobulin class switching , 1984, Cell.

[43]  T. Honjo,et al.  Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. , 1982, The Journal of biological chemistry.

[44]  T. Honjo,et al.  Organization of immunoglobulin heavy chain genes and allelic deletion model. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[45]  T. Honjo,et al.  Molecular mechanism of immunoglobulin class switch recombination. , 1999, Cold Spring Harbor symposia on quantitative biology.