Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response
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[1] J. Haines,et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult onset ALS and ALS/dementia , 2011, Nature.
[2] M. Sporn,et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. , 2011, Free radical biology & medicine.
[3] C. Haass,et al. TDP-43 and FUS: a nuclear affair , 2011, Trends in Neurosciences.
[4] V. Crippa,et al. Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis , 2011, Journal of neurochemistry.
[5] F. Baas,et al. Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation , 2011, Neurobiology of Disease.
[6] Cole M. Haynes,et al. Mitochondrial protein quality control during biogenesis and aging. , 2011, Trends in biochemical sciences.
[7] A. Gitler,et al. Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS , 2011, PLoS biology.
[8] O. Hardiman,et al. Amyotrophic lateral sclerosis , 2011, The Lancet.
[9] M. Glickman,et al. Proteasome Activator 200: The HEAT is on…* , 2011, Molecular & Cellular Proteomics.
[10] W. Robberecht,et al. Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease , 2011, The Lancet Neurology.
[11] T. Hortobágyi,et al. Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders , 2011, Acta Neuropathologica.
[12] Yong-jian Liu,et al. FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration , 2011, PLoS genetics.
[13] R. Takahashi,et al. Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease , 2011, Acta Neuropathologica.
[14] Suneil K. Kalia,et al. Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5) , 2011, PloS one.
[15] Lei Mao,et al. Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury , 2011, Brain injury.
[16] K. Bhat,et al. Proteolytic and non-proteolytic roles of ubiquitin and the ubiquitin proteasome system in transcriptional regulation. , 2011, Biochimica et biophysica acta.
[17] J. Trojanowski,et al. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. , 2011, The Journal of clinical investigation.
[18] D. Ito,et al. Nuclear transport impairment of amyotrophic lateral sclerosis‐linked mutations in FUS/TLS , 2011, Annals of neurology.
[19] P. Gordon. Amyotrophic Lateral Sclerosis , 2011, CNS Drugs.
[20] Adriano Chiò,et al. The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials , 2011, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
[21] K. Hashimoto,et al. Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice , 2010, Journal of biomedicine & biotechnology.
[22] Sonja W. Scholz,et al. Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS , 2010, Neuron.
[23] M. de Carvalho,et al. Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis. , 2010, CNS & neurological disorders drug targets.
[24] Y. Qiu,et al. Processing of Optineurin in Neuronal Cells* , 2010, The Journal of Biological Chemistry.
[25] C. Hetz,et al. Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway. , 2010, Antioxidants & redox signaling.
[26] A. Henn,et al. Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice , 2010, The Journal of Immunology.
[27] Wei Yan,et al. The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice , 2010, Acta Pharmacologica Sinica.
[28] Han-Jou Chen,et al. Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis , 2010, The Journal of Biological Chemistry.
[29] L. Petrucelli,et al. Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue , 2010, PloS one.
[30] I. Mackenzie,et al. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia , 2010, The Lancet Neurology.
[31] C. Bendotti,et al. A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases , 2010, Autophagy.
[32] Jeffery N Agar,et al. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS , 2010, Nature Neuroscience.
[33] Jong-Bok Yoon,et al. ASK1 Negatively Regulates the 26 S Proteasome*♦ , 2010, The Journal of Biological Chemistry.
[34] C. Garrido,et al. Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27* , 2010, The Journal of Biological Chemistry.
[35] C. Bendotti,et al. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). , 2010, Human molecular genetics.
[36] V. Shoshan-Barmatz,et al. Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS , 2010, Neuron.
[37] P. Kloetzel,et al. Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress , 2010, Cell.
[38] C. Bendotti,et al. Unraveling the complexity of amyotrophic lateral sclerosis: recent advances from the transgenic mutant SOD1 mice. , 2010, CNS & neurological disorders drug targets.
[39] Johan Jacobsson,et al. Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients , 2010, PloS one.
[40] Pinar Mesci,et al. Author manuscript, published in "Journal of Neural Transmission 2010;117(8):981-1000" DOI: 10.1007/s00702-010-0429-0 A G Barbeito et al. Motor neuron-immune interactions Motor neuron- immune interactions: the vicious circle of ALS , 2010 .
[41] J. Trojanowski,et al. TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97 , 2010, The Journal of Neuroscience.
[42] E. Mugnaini,et al. FUS‐immunoreactive inclusions are a common feature in sporadic and non‐SOD1 familial amyotrophic lateral sclerosis , 2010, Annals of neurology.
[43] Takeo Kato,et al. Mutations of optineurin in amyotrophic lateral sclerosis , 2010, Nature.
[44] Robert H. Brown,et al. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2 , 2010, Human molecular genetics.
[45] S. Perrin,et al. From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis , 2010, Nature Genetics.
[46] D. Cleveland,et al. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. , 2010, Human molecular genetics.
[47] C. M. Freria,et al. Major histocompatability complex class I expression and glial reaction influence spinal motoneuron synaptic plasticity during the course of experimental autoimmune encephalomyelitis , 2010, The Journal of comparative neurology.
[48] Paul G. Ince,et al. Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) , 2010, PloS one.
[49] K. Sadre-Bazzaz,et al. Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. , 2010, Molecular cell.
[50] Do Hee Lee,et al. CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6′ subunits of 26S proteasome , 2010 .
[51] M. Piccinini,et al. TDP‐43 Redistribution is an Early Event in Sporadic Amyotrophic Lateral Sclerosis , 2010, Brain pathology.
[52] R. Bowser,et al. Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene , 2010, PLoS genetics.
[53] S. Pereson,et al. TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration , 2010, Proceedings of the National Academy of Sciences.
[54] G. Rouleau,et al. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. , 2010, Human molecular genetics.
[55] M. Figueiredo-Pereira,et al. Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications , 2010, Apoptosis.
[56] C. Oliveira,et al. Frontiers in Aging Neuroscience Aging Neuroscience Perspective Article Parkinson's Disease Etiopathogenesis Cross-talk between Mitochondria and Proteasome in Parkinson's Disease Pathogenesis , 2022 .
[57] Fumiaki Tanaka,et al. Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis , 2010, Journal of neuroscience research.
[58] S. Appel,et al. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? , 2010, Trends in immunology.
[59] B. Dubois,et al. FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis. , 2010, Journal of Alzheimer's disease : JAD.
[60] R. Bandopadhyay,et al. Pathogenesis of Parkinson's disease: emerging role of molecular chaperones. , 2010, Trends in molecular medicine.
[61] M. Groettrup,et al. Proteasomes in immune cells: more than peptide producers? , 2010, Nature Reviews Immunology.
[62] T. Iwaki,et al. Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation , 2010, Acta Neuropathologica.
[63] D. Piwnica-Worms,et al. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease , 2009, The Journal of cell biology.
[64] D. Cleveland,et al. Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond , 2009, The Journal of cell biology.
[65] Tom Maniatis,et al. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice , 2009, Proceedings of the National Academy of Sciences.
[66] M. Strong,et al. Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis , 2009, PloS one.
[67] Hitoshi Takahashi,et al. Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice , 2009, Neurobiology of Disease.
[68] Guanghui Wang,et al. Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. , 2009, Human molecular genetics.
[69] N. Cairns,et al. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration , 2009, Proceedings of the National Academy of Sciences.
[70] S. Yanagi,et al. Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. , 2009, Molecular biology of the cell.
[71] G. Rouleau,et al. A Mutation that Creates a Pseudoexon in SOD1 Causes Familial ALS , 2009, Annals of human genetics.
[72] H. Kretzschmar,et al. A new subtype of frontotemporal lobar degeneration with FUS pathology. , 2009, Brain : a journal of neurology.
[73] S. Cullheim,et al. Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction , 2009, The Journal of Neuroscience.
[74] G. Comi,et al. Mutations of FUS gene in sporadic amyotrophic lateral sclerosis , 2009, Journal of Medical Genetics.
[75] M. Meisler,et al. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2 , 2009, Human molecular genetics.
[76] D. Vocadlo,et al. Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS , 2009, Neuroscience Letters.
[77] D. Finley,et al. Recognition and processing of ubiquitin-protein conjugates by the proteasome. , 2009, Annual review of biochemistry.
[78] G. Mora,et al. Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process , 2009, Journal of Neuroimmunology.
[79] G. Manfredi,et al. Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis. , 2009, Antioxidants & redox signaling.
[80] C. Crosio,et al. Oligomerization of mutant SOD1 in mitochondria of motoneuronal cells drives mitochondrial damage and cell toxicity. , 2009, Antioxidants & redox signaling.
[81] Xuejun Wang,et al. Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies. , 2009, International journal of physiology, pathophysiology and pharmacology.
[82] P. Caroni,et al. A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice , 2009, Nature Neuroscience.
[83] M. Pennuto,et al. Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity. , 2009, Human Molecular Genetics.
[84] Xun Hu,et al. Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 , 2009, Science.
[85] J L Haines,et al. Supporting Online Material Materials and Methods Figs. S1 to S7 Tables S1 to S4 References Mutations in the Fus/tls Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis , 2022 .
[86] Robert H. Brown,et al. Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. , 2009, American journal of human genetics.
[87] J. Rothstein,et al. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis , 2009, Annals of neurology.
[88] S. Appel. CD4+ T cells mediate cytotoxicity in neurodegenerative diseases. , 2008, The Journal of clinical investigation.
[89] Jinsy A. Andrews,et al. Amyotrophic lateral sclerosis: Clinical management and research update , 2009, Current neurology and neuroscience reports.
[90] C. Cheroni,et al. Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis. , 2009, Human molecular genetics.
[91] Suzanne Tydlacka,et al. Differential Activities of the Ubiquitin–Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons , 2008, The Journal of Neuroscience.
[92] J. Taylor,et al. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. , 2008, Biochimica et biophysica acta.
[93] I. Chiu,et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS , 2008, Proceedings of the National Academy of Sciences.
[94] Xiao-Jiang Li,et al. Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases , 2008, Brain Research Reviews.
[95] S. Petri,et al. Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis , 2008, Journal of neuropathology and experimental neurology.
[96] K. Talbot,et al. TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy , 2008, BMC Neuroscience.
[97] T. Pandita,et al. Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability , 2008, Proceedings of the National Academy of Sciences.
[98] S. Appel,et al. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS , 2008, Proceedings of the National Academy of Sciences.
[99] M. Kwak,et al. Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway. , 2008, Biochemical pharmacology.
[100] Honglin Luo,et al. REGγ, a proteasome activator and beyond? , 2008, Cellular and Molecular Life Sciences.
[101] Hermann Schindelin,et al. Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes , 2008, Cell.
[102] J. Trojanowski,et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. , 2008, The American journal of pathology.
[103] J. Agar,et al. Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis , 2008, Journal of neurochemistry.
[104] Christos G. Gkogkas,et al. VAPB interacts with and modulates the activity of ATF6. , 2008, Human molecular genetics.
[105] Takanori Yokota,et al. Als-linked Mutant Sod1 Induces Er Stress-and Ask1-dependent Motor Neuron Death by Targeting Derlin-1 -induced Cell Death Remains Controversial. Here We Show That Sod1 Mut Specifically Interacted with Derlin-1, a Component of Endoplasmic Reticulum (er)-associated Degradation (erad) Machinery and Trig , 2022 .
[106] K. Talbot,et al. Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS , 2008, Progress in Neurobiology.
[107] Murray Grossman,et al. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis , 2008, The Lancet Neurology.
[108] V. Blank. Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? , 2008, Journal of molecular biology.
[109] Alberto Ferri,et al. Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications. , 2008, Antioxidants & redox signaling.
[110] J. McCabe,et al. Alterations of cerebral cortex and hippocampal proteasome subunit expression and function in a traumatic brain injury rat model , 2007, Journal of neurochemistry.
[111] N. Mizushima,et al. Autophagosomes in GFP-LC3 Transgenic Mice. , 2008, Methods in molecular biology.
[112] M. Kwak,et al. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. , 2007, European journal of pharmacology.
[113] H. Cai,et al. The G59S Mutation in p150glued Causes Dysfunction of Dynactin in Mice , 2007, The Journal of Neuroscience.
[114] L. Zinman,et al. Evidence That TDP-43 is Not the Major Ubiquitinated Target Within the Pathological Inclusions of Amyotrophic Lateral Sclerosis , 2007, Journal of neuropathology and experimental neurology.
[115] M. Portero-Otín,et al. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. , 2007, Brain : a journal of neurology.
[116] S. Kato. Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences , 2007, Acta Neuropathologica.
[117] B. Traynor,et al. Genetics of sporadic amyotrophic lateral sclerosis. , 2007, Human molecular genetics.
[118] D. Klionsky,et al. Autophagosome formation: core machinery and adaptations , 2007, Nature Cell Biology.
[119] L. Ferraiuolo,et al. Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS , 2007, The Journal of Neuroscience.
[120] L. Barbeito,et al. Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis , 2007, The Journal of Neuroscience.
[121] L. Martini,et al. Aggregation and proteasome: The case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy , 2007, Neurobiology of Aging.
[122] L. Kaer,et al. Assessing the role of immuno-proteasomes in a mouse model of familial ALS , 2007, Experimental Neurology.
[123] P. Riso,et al. Mutation of SOD1 in ALS: a gain of a loss of function. , 2007, Human molecular genetics.
[124] E. Pioro,et al. Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS , 2007, Neuroscience Letters.
[125] Jung-Ae Kim,et al. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. , 2007, Life sciences.
[126] P. Fraser,et al. SUMO on the road to neurodegeneration. , 2007, Biochimica et biophysica acta.
[127] Oliver Kerscher,et al. SUMO junction—what's your function? , 2007, EMBO reports.
[128] Fumiaki Tanaka,et al. CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model , 2007, The Journal of Neuroscience.
[129] J. Trojanowski,et al. Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations , 2007, Annals of neurology.
[130] Murray Grossman,et al. TDP-43-Positive White Matter Pathology in Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions , 2007, Journal of neuropathology and experimental neurology.
[131] O. Isacson,et al. Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells , 2007, PloS one.
[132] A. Salminen,et al. Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis , 2007, Molecular Pharmacology.
[133] X. Yao,et al. SUMO-1 modification increases human SOD1 stability and aggregation , 2006, Neuroscience Research.
[134] Sebastiano Cavallaro,et al. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis , 2007, BMC Genomics.
[135] M. Salmona,et al. Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice* , 2006, Journal of Biological Chemistry.
[136] K. Wada,et al. Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome* , 2006, Journal of Biological Chemistry.
[137] M. Hochstrasser,et al. Modification of proteins by ubiquitin and ubiquitin-like proteins. , 2006, Annual review of cell and developmental biology.
[138] Bruce L. Miller,et al. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis , 2006, Science.
[139] D. Cleveland,et al. ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors , 2006, Neuron.
[140] M. McGrath,et al. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS) , 2006, Journal of Neuroimmunology.
[141] Robert H. Brown,et al. Molecular biology of amyotrophic lateral sclerosis: insights from genetics , 2006, Nature Reviews Neuroscience.
[142] M. Kwak,et al. Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. , 2006, Biochemical and biophysical research communications.
[143] Hideyuki Okano,et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.
[144] P. Fraser,et al. Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein* , 2006, Journal of Biological Chemistry.
[145] S. Appel,et al. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS , 2006, Molecular and Cellular Neuroscience.
[146] T. Grune,et al. Proteasomal defense of oxidative protein modifications. , 2006, Antioxidants & redox signaling.
[147] J. Julien,et al. Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS , 2006, Molecular and Cellular Neuroscience.
[148] Jing Zhao,et al. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents , 2006, Neuroscience Letters.
[149] J. Elliott,et al. Non-neuronal induction of immunoproteasome subunits in an ALS model: Possible mediation by cytokines , 2005, Experimental Neurology.
[150] Yukio Fujita,et al. Golgi apparatus of the motor neurons in patients with amyotrophic lateral sclerosis and in mice models of amyotrophic lateral sclerosis , 2005, Neuropathology : official journal of the Japanese Society of Neuropathology.
[151] E. Buratti,et al. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene , 2005, Nucleic acids research.
[152] M. Masucci,et al. Endoplasmic reticulum stress compromises the ubiquitin-proteasome system. , 2005, Human molecular genetics.
[153] D. Butterfield,et al. Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis. , 2005, Free radical biology & medicine.
[154] M. Strong,et al. The Pathobiology of Amyotrophic Lateral Sclerosis: A Proteinopathy? , 2005, Journal of neuropathology and experimental neurology.
[155] J. Valentine,et al. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. , 2005, Annual review of biochemistry.
[156] M. Salmona,et al. Protein Nitration in a Mouse Model of Familial Amyotrophic Lateral Sclerosis , 2005, Journal of Biological Chemistry.
[157] P. Cascio,et al. Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome , 2005, Neurobiology of Disease.
[158] Keiji Tanaka,et al. Co-chaperone CHIP Associates with Expanded Polyglutamine Protein and Promotes Their Degradation by Proteasomes* , 2005, Journal of Biological Chemistry.
[159] Ralph A. Nixon,et al. Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study , 2005, Journal of neuropathology and experimental neurology.
[160] David H Russell,et al. A Universal Strategy for Proteomic Studies of SUMO and Other Ubiquitin-like Modifiers*S , 2005, Molecular & Cellular Proteomics.
[161] J. Yewdell,et al. Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. , 2005, Annual review of immunology.
[162] C. Hill,et al. Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors. , 2005, Trends in cell biology.
[163] B. Ulfhake,et al. MHC Class I, β2 microglobulin, and the INF‐γ receptor are upregulated in aged motoneurons , 2004 .
[164] Tohru Natsume,et al. Physical and Functional Interaction between Dorfin and Valosin-containing Protein That Are Colocalized in Ubiquitylated Inclusions in Neurodegenerative Disorders* , 2004, Journal of Biological Chemistry.
[165] A. Amerik,et al. Mechanism and function of deubiquitinating enzymes. , 2004, Biochimica et biophysica acta.
[166] T. Gillingwater,et al. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. , 2004, American journal of human genetics.
[167] R. Agami,et al. AAA ATPase p97/Valosin-containing Protein Interacts with gp78, a Ubiquitin Ligase for Endoplasmic Reticulum-associated Degradation* , 2004, Journal of Biological Chemistry.
[168] John R Yates,et al. Global Analysis of Protein Sumoylation in Saccharomyces cerevisiae* , 2004, Journal of Biological Chemistry.
[169] Sung Goo Park,et al. Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes. , 2004, Biochemical and biophysical research communications.
[170] C. Bendotti,et al. Lessons from models of SOD1-linked familial ALS. , 2004, Trends in molecular medicine.
[171] K. Nakayama,et al. CHIP promotes proteasomal degradation of familial ALS‐linked mutant SOD1 by ubiquitinating Hsp/Hsc70 , 2004, Journal of neurochemistry.
[172] G. Scott,et al. UCH‐L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease , 2004, Journal of neurochemistry.
[173] Carla J. Shatz,et al. Immune signalling in neural development, synaptic plasticity and disease , 2004, Nature Reviews Neuroscience.
[174] C. Ross,et al. Protein aggregation and neurodegenerative disease , 2004, Nature Medicine.
[175] E. Buratti,et al. Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance. , 2004, American journal of human genetics.
[176] T. Uehara,et al. Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin‐associated and ubiquitin‐like domains , 2004, FEBS letters.
[177] I. Nishimoto,et al. Alsin, the Product of ALS2 Gene, Suppresses SOD1 Mutant Neurotoxicity through RhoGEF Domain by Interacting with SOD1 Mutants* , 2004, Journal of Biological Chemistry.
[178] P. Pandolfi,et al. SUMO Modification of Huntingtin and Huntington's Disease Pathology , 2004, Science.
[179] Y. Itoyama,et al. NEDL1, a Novel Ubiquitin-protein Isopeptide Ligase for Dishevelled-1, Targets Mutant Superoxide Dismutase-1* , 2004, Journal of Biological Chemistry.
[180] C. Kunsch,et al. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. , 2004, Current pharmaceutical design.
[181] A. Lieberman. SUMO, a ubiquitin-like modifier implicated in neurodegeneration , 2004, Experimental Neurology.
[182] J. Glass,et al. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man , 2004, Experimental Neurology.
[183] M. Strong,et al. Activated p38MAPK Is a Novel Component of the Intracellular Inclusions Found in Human Amyotrophic Lateral Sclerosis and Mutant SOD1 Transgenic Mice , 2004, Journal of neuropathology and experimental neurology.
[184] T. Siddique,et al. Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue , 2004, Annals of neurology.
[185] P. Andersen,et al. Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis. , 2004, Brain : a journal of neurology.
[186] Isidro Ferrer,et al. Neuronal Induction of the Immunoproteasome in Huntington's Disease , 2003, The Journal of Neuroscience.
[187] M. Kwak,et al. Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway , 2003, Molecular and Cellular Biology.
[188] Aaron Ciechanover,et al. The Ubiquitin Proteasome System in Neurodegenerative Diseases Sometimes the Chicken, Sometimes the Egg , 2003, Neuron.
[189] G. Sobue,et al. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. , 2003, The American journal of pathology.
[190] Jeremy N. Skepper,et al. α-Synuclein Is Degraded by Both Autophagy and the Proteasome* , 2003, Journal of Biological Chemistry.
[191] J. Valentine,et al. Misfolded CuZnSOD and amyotrophic lateral sclerosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[192] F. Menzies,et al. Analysis of the Cytosolic Proteome in a Cell Culture Model of Familial Amyotrophic Lateral Sclerosis Reveals Alterations to the Proteasome, Antioxidant Defenses, and Nitric Oxide Synthetic Pathways* , 2003, The Journal of Biological Chemistry.
[193] H. Yasuda,et al. SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death , 2002, Neuroreport.
[194] R. Takahashi,et al. Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis , 2002, Journal of neurochemistry.
[195] G. Sobue,et al. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords – screening by molecular indexing and subsequent cDNA microarray analysis , 2002, FEBS letters.
[196] A. Goldberg,et al. The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. , 2002, Molecular immunology.
[197] Naoyuki Taniguchi,et al. Dorfin Ubiquitylates Mutant SOD1 and Prevents Mutant SOD1-mediated Neurotoxicity* , 2002, The Journal of Biological Chemistry.
[198] T. Yao,et al. A cryptic protease couples deubiquitination and degradation by the proteasome , 2002, Nature.
[199] A. Goldberg,et al. Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes , 2002, The EMBO journal.
[200] Rainer Duden,et al. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. , 2002, Human molecular genetics.
[201] A. Ciechanover,et al. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. , 2002, Physiological reviews.
[202] J. Hauw,et al. The relationship between Bunina bodies, skein-like inclusions and neuronal loss in amyotrophic lateral sclerosis , 2002, Acta Neuropathologica.
[203] D. Price,et al. Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues , 2001, Neurobiology of Disease.
[204] M. Ferrone,et al. The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[205] L. Barbeito,et al. Superoxide dismutase and the death of motoneurons in ALS , 2001, Trends in Neurosciences.
[206] V. Silani,et al. Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity , 2001, Journal of the Neurological Sciences.
[207] S. Appel,et al. Immune reactivity in a mouse model of familial ALS correlates with disease progression , 2001, Neurology.
[208] Francisco E. Baralle,et al. Characterization and Functional Implications of the RNA Binding Properties of Nuclear Factor TDP-43, a Novel Splicing Regulator ofCFTR Exon 9* , 2001, The Journal of Biological Chemistry.
[209] Chou-Chi H. Li,et al. Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation , 2001, Nature Cell Biology.
[210] C. Pickart,et al. Mechanisms underlying ubiquitination. , 2001, Annual review of biochemistry.
[211] R. Kopito,et al. Aggresomes, inclusion bodies and protein aggregation. , 2000, Trends in cell biology.
[212] M. Gurney,et al. Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[213] A. Ciechanover,et al. Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway , 2000, The Journal of Biological Chemistry.
[214] P. Connell,et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins , 2000, Nature Cell Biology.
[215] D. Cyr,et al. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation , 2000, Nature Cell Biology.
[216] T. Olsson,et al. Expression of MHC class I heavy chain and β2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons , 1999, Journal of Neuroimmunology.
[217] P. Connell,et al. Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions , 1999, Molecular and Cellular Biology.
[218] P. Kloetzel,et al. A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome. , 1999, Journal of molecular biology.
[219] R. Hay,et al. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. , 1998, Molecular cell.
[220] J. Kong,et al. Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1 , 1998, The Journal of Neuroscience.
[221] S. Cullheim,et al. Expression of MHC Class I and β2-Microglobulin in Rat Spinal Motoneurons: Regulatory Influences by IFN-Gamma and Axotomy , 1998, Experimental Neurology.
[222] Z. Mourelatos,et al. The fragmented neuronal Golgi apparatus in amyotrophic lateral sclerosis includes the trans-Golgi-network: functional implications , 1998, Acta Neuropathologica.
[223] Y. Agid,et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. , 1997, Histology and histopathology.
[224] E. K. Hoffman,et al. Proteasome inhibition enhances the stability of mouse Cu Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis , 1996, Journal of the Neurological Sciences.
[225] A. Haas,et al. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination , 1995, Molecular and cellular biology.
[226] Aaron Ciechanover,et al. The ubiquitin-proteasome proteolytic pathway , 1994, Cell.
[227] M. Gurney,et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.
[228] J. Haines,et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.
[229] C. Larsen,et al. Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases. , 1992, Biochemical Society transactions.
[230] P. Mcgeer,et al. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. , 1992, The American journal of pathology.
[231] M. Swash,et al. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. , 1991, Brain : a journal of neurology.
[232] D. Troost,et al. Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis , 1990, Neuropathology and applied neurobiology.
[233] P. Kushner,et al. Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis , 1990, Annals of neurology.
[234] Pierluigi Gambetti,et al. Ubiquitinated filamentous inclusions in spinal cord of patients with motor neuron disease , 1990, Neuroscience Letters.
[235] J. Lowe,et al. Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases , 1990, The Journal of pathology.
[236] D. Troost,et al. Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. , 1989, Clinical neuropathology.