Nonsense-mediated mRNA decay in Saccharomyces cerevisiae.

[1]  S. Peltz,et al.  The role of Upf proteins in modulating the translation read‐through of nonsense‐containing transcripts , 2001, The EMBO journal.

[2]  R. Parker,et al.  The Transcription Factor Associated Ccr4 and Caf1 Proteins Are Components of the Major Cytoplasmic mRNA Deadenylase in Saccharomyces cerevisiae , 2001, Cell.

[3]  L. Maquat,et al.  Quality Control of mRNA Function , 2001, Cell.

[4]  L. Maquat,et al.  Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4) , 2001, Molecular and Cellular Biology.

[5]  L. Maquat,et al.  Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. , 2001, RNA.

[6]  J. Steitz,et al.  Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon , 2000, Cell.

[7]  H. Le Hir,et al.  The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions , 2000, The EMBO journal.

[8]  J. Mendell,et al.  Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes , 2000, Molecular and Cellular Biology.

[9]  M. Nagel,et al.  Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3'-untranslated region by the mRNA endonuclease polysomal ribonuclease 1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Mango,et al.  A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. , 2000, Science.

[11]  S. Peltz,et al.  Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. , 2000, RNA.

[12]  J. Yong,et al.  Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. , 2000, Molecular cell.

[13]  M. Kiledjian,et al.  The Poly(A)-Binding Protein and an mRNA Stability Protein Jointly Regulate an Endoribonuclease Activity , 2000, Molecular and Cellular Biology.

[14]  B. Lapeyre,et al.  The Two Proteins Pat1p (Mrt1p) and Spb8p Interact In Vivo, Are Required for mRNA Decay, and Are Functionally Linked to Pab1p , 2000, Molecular and Cellular Biology.

[15]  J. McCarthy,et al.  The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex , 2000, The EMBO journal.

[16]  F. He,et al.  Upf1p Control of Nonsense mRNA Translation Is Regulated by Nmd2p and Upf3p , 2000, Molecular and Cellular Biology.

[17]  M. Ruiz-Echevarría,et al.  The RNA Binding Protein Pub1 Modulates the Stability of Transcripts Containing Upstream Open Reading Frames , 2000, Cell.

[18]  H. Le Hir,et al.  Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. , 2000, Genes & development.

[19]  F. Sherman,et al.  The Role of Nuclear Cap Binding Protein Cbc1p of Yeast in mRNA Termination and Degradation , 2000, Molecular and Cellular Biology.

[20]  Bertrand Séraphin,et al.  A Sm‐like protein complex that participates in mRNA degradation , 2000, The EMBO journal.

[21]  Jean D. Beggs,et al.  Yeast Sm-like proteins function in mRNA decapping and decay , 2000, Nature.

[22]  M. Ruiz-Echevarría,et al.  The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay. , 2000, Molecular cell.

[23]  M. Kiledjian,et al.  Identification of an erythroid‐enriched endoribonuclease activity involved in specific mRNA cleavage , 2000, The EMBO journal.

[24]  S. Peltz,et al.  29 Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae , 2000 .

[25]  L. Maquat.  30 Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation , 2000 .

[26]  N. Sonenberg,et al.  Translational control of gene expression , 2000 .

[27]  L. Maquat,et al.  mRNA surveillance in mammalian cells: the relationship between introns and translation termination. , 2000, RNA.

[28]  A. Jacobson,et al.  An internal open reading frame triggers nonsense‐mediated decay of the yeast SPT10 mRNA , 1999, The EMBO journal.

[29]  R. Parker,et al.  Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping. , 1999, Molecular biology of the cell.

[30]  S. Peltz,et al.  Mutations in VPS16 and MRT1Stabilize mRNAs by Activating an Inhibitor of the Decapping Enzyme , 1999, Molecular and Cellular Biology.

[31]  M. Wilm,et al.  A doughnut‐shaped heteromer of human Sm‐like proteins binds to the 3′‐end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro , 1999, The EMBO journal.

[32]  R Parker,et al.  Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance. , 1999, RNA.

[33]  M. Culbertson,et al.  Yeast Upf Proteins Required for RNA Surveillance Affect Global Expression of the Yeast Transcriptome , 1999, Molecular and Cellular Biology.

[34]  T. Dunckley,et al.  The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif , 1999, The EMBO journal.

[35]  K. Anders,et al.  SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast , 1999, Molecular and Cellular Biology.

[36]  A. Fire,et al.  RNA-triggered gene silencing. , 1999, Trends in genetics : TIG.

[37]  M. Ruiz-Echevarría,et al.  Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[38]  Roy Parker,et al.  Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs inSaccharomyces cerevisiae , 1999, Molecular and Cellular Biology.

[39]  S. Peltz,et al.  Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay. , 1999, RNA.

[40]  C. Rodrigues-Pousada,et al.  Post‐termination ribosome interactions with the 5′UTR modulate yeast mRNA stability , 1999, The EMBO journal.

[41]  M. Hentze,et al.  A Perfect Message RNA Surveillance and Nonsense-Mediated Decay , 1999, Cell.

[42]  M. Culbertson,et al.  RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. , 1999, Trends in genetics : TIG.

[43]  P. Anderson,et al.  smg-7 is required for mRNA surveillance in Caenorhabditis elegans. , 1999, Genetics.

[44]  R. Parker,et al.  Mechanisms of mRNA surveillance in eukaryotes. , 1999, Annual review of genetics.

[45]  M. Swanson,et al.  Control of cleavage site selection during mRNA 3′ end formation by a yeast hnRNP , 1998, The EMBO journal.

[46]  E. Chernokalskaya,et al.  A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family. , 1998, RNA.

[47]  J. McCarthy,et al.  Posttranscriptional Control of Gene Expression in Yeast , 1998, Microbiology and Molecular Biology Reviews.

[48]  A. Sachs,et al.  Poly(A) Tail Length Control in Saccharomyces cerevisiae Occurs by Message-Specific Deadenylation , 1998, Molecular and Cellular Biology.

[49]  P. Hieter,et al.  Accumulation of mRNA coding for the ctf13p kinetochore subunit of Saccharomyces cerevisiae depends on the same factors that promote rapid decay of nonsense mRNAs. , 1998, Genetics.

[50]  L. R. Schenkman,et al.  A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence. , 1998, Journal of cell science.

[51]  J. Berman,et al.  Telomere Length Regulation and Telomeric Chromatin Require the Nonsense-Mediated mRNA Decay Pathway , 1998, Molecular and Cellular Biology.

[52]  L. Maquat,et al.  At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation , 1998, Molecular and Cellular Biology.

[53]  L. Maquat,et al.  A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. Ruiz-Echevarría,et al.  The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  L. Maquat,et al.  Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. , 1998, RNA.

[56]  M. Hentze,et al.  Binary specification of nonsense codons by splicing and cytoplasmic translation , 1998, The EMBO journal.

[57]  M. Ruiz-Echevarría,et al.  The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. , 1998, Genes & development.

[58]  L. Maquat,et al.  A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. , 1998, Trends in biochemical sciences.

[59]  A. Jacobson,et al.  A single amino acid substitution in yeast eIF‐5A results in mRNA stabilization , 1998, The EMBO journal.

[60]  R. Parker,et al.  The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex , 1998, The EMBO journal.

[61]  R. Parker,et al.  Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme , 1998, The EMBO journal.

[62]  S. Peltz,et al.  The Mof2/Sui1 Protein Is a General Monitor of Translational Accuracy , 1998, Molecular and Cellular Biology.

[63]  C. Rodrigues-Pousada,et al.  The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. , 1998, Nucleic acids research.

[64]  Shulin Li,et al.  Nonsense surveillance in lymphocytes? , 1998, Immunity.

[65]  S. Peltz,et al.  ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities. , 1998, RNA.

[66]  M. Ruiz-Echevarría,et al.  Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA , 1998, The EMBO journal.

[67]  J. Clancy,et al.  Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line , 1997, Nature Medicine.

[68]  Marco M. Kessler,et al.  Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast. , 1997, Genes & development.

[69]  L. R. Schenkman,et al.  Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay* , 1997, The Journal of Biological Chemistry.

[70]  R. Pictet,et al.  Messenger RNA deadenylylation precedes decapping in mammalian cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[71]  S. Peltz,et al.  Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae. , 1997, RNA.

[72]  F. He,et al.  Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway , 1997, Molecular and cellular biology.

[73]  Jean-Marie Buerstedde,et al.  A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates , 1997, The Journal of cell biology.

[74]  H. Jäck,et al.  Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. , 1997, Nucleic acids research.

[75]  J. Malter,et al.  Cytoplasmic fate of eukaryotic mRNA: identification and characterization of AU-binding proteins. , 1997, Progress in molecular and subcellular biology.

[76]  M. Carter,et al.  A splicing‐dependent regulatory mechanism that detects translation signals. , 1996, The EMBO journal.

[77]  Charles E. Martin,et al.  Fatty Acid-responsive Control of mRNA Stability , 1996, The Journal of Biological Chemistry.

[78]  S. Peltz,et al.  Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover , 1996, Molecular and cellular biology.

[79]  S. Peltz,et al.  Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein , 1996, Molecular and cellular biology.

[80]  S. Peltz,et al.  Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. , 1996, The EMBO journal.

[81]  F. Spencer,et al.  Mammalian orthologues of a yeast regulator of nonsense transcript stability. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[82]  R. Parker,et al.  Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae , 1996, Molecular and cellular biology.

[83]  G. Caponigro,et al.  An essential component of the decapping enzyme required for normal rates of mRNA turnover , 1996, Nature.

[84]  M. Ruiz-Echevarría,et al.  Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense‐mediated mRNA decay. , 1996, The EMBO journal.

[85]  B. Haynes,et al.  A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. , 1996, Immunity.

[86]  M. Rieger,et al.  The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity * , 1996, The Journal of Biological Chemistry.

[87]  M. Culbertson,et al.  Identification of an additional gene required for eukaryotic nonsense mRNA turnover. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[88]  J. Ross,et al.  mRNA stability in mammalian cells. , 1995, Microbiological reviews.

[89]  S. Peltz,et al.  Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation. , 1995, RNA.

[90]  M. Ruiz-Echevarría,et al.  Identification and Characterization of a Sequence Motif Involved in Nonsense-Mediated mRNA Decay , 2022 .

[91]  R Parker,et al.  Turnover mechanisms of the stable yeast PGK1 mRNA , 1995, Molecular and cellular biology.

[92]  S. Peltz,et al.  Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. , 1995, Genes & development.

[93]  F. He,et al.  Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. , 1995, Genes & development.

[94]  M. Ruiz-Echevarría,et al.  Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover , 1995, Molecular and cellular biology.

[95]  L. Maquat,et al.  Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance , 1994, Molecular and cellular biology.

[96]  S. Thein,et al.  Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemia. , 1994, Blood.

[97]  R Parker,et al.  Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. , 1994, Genes & development.

[98]  R. Parker,et al.  Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. , 1994, The Journal of biological chemistry.

[99]  R D Klausner,et al.  Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. , 1994, The EMBO journal.

[100]  R. Wickner,et al.  Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies. , 1994, Genetics.

[101]  R. Pulak,et al.  mRNA surveillance by the Caenorhabditis elegans smg genes. , 1993, Genes & development.

[102]  S. Peltz,et al.  mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. , 1993, Genes & development.

[103]  R. Harland,et al.  Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. , 1993, Genes & development.

[104]  C L Hsu,et al.  Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure , 1993, Molecular and cellular biology.

[105]  R Parker,et al.  A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. , 1993, Genes & development.

[106]  S. Peltz,et al.  Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[107]  R. Schneider,et al.  Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism , 1993, Molecular and cellular biology.

[108]  E. Koonin.  A new group of putative RNA helicases. , 1992, Trends in biochemical sciences.

[109]  S. Peltz,et al.  A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae , 1992, Molecular and cellular biology.

[110]  M. Hampsey,et al.  cis- and trans-acting suppressors of a translation initiation defect at the cyc1 locus of Saccharomyces cerevisiae. , 1992, Genetics.

[111]  I. Scheffler,et al.  Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae , 1992, Molecular and cellular biology.

[112]  M. Culbertson,et al.  Gene products that promote mRNA turnover in Saccharomyces cerevisiae , 1992, Molecular and cellular biology.

[113]  P. Slonimski,et al.  NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae. , 1992, Journal of molecular biology.

[114]  M. Hampsey,et al.  Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. , 1991, Biochimie.

[115]  S. Peltz,et al.  The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. , 1991, Genes & development.

[116]  M. Greenberg,et al.  Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. , 1991, Genes & development.

[117]  R Parker,et al.  Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae , 1990, Molecular and cellular biology.

[118]  M. Greenberg,et al.  Deadenylylation: a mechanism controlling c-fos mRNA decay. , 1990, Enzyme.

[119]  I. Verma,et al.  Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos. , 1989, Oncogene research.

[120]  G. Schuler,et al.  GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor , 1988, Cell.

[121]  A. Stevens.  mRNA-decapping enzyme from Saccharomyces cerevisiae: purification and unique specificity for long RNA chains , 1988, Molecular and cellular biology.

[122]  G. Fink,et al.  Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors. , 1980, Genetics.

[123]  R. Losson,et al.  Interference of nonsense mutations with eukaryotic messenger RNA stability. , 1979, Proceedings of the National Academy of Sciences of the United States of America.