Asymptotic stability of a genetic network under impulsive control

The study of the stability of genetic network is an important motif for the understanding of the living organism at both molecular and cellular levels. In this Letter, we provide a theoretical method for analyzing the asymptotic stability of a genetic network under impulsive control. And the sufficient conditions of its asymptotic stability under impulsive control are obtained. Finally, an example is given to illustrate the effectiveness of the obtained method.

[1]  D. A. Baxter,et al.  Mathematical Modeling of Gene Networks , 2000, Neuron.

[2]  Hidde de Jong,et al.  Modeling and Simulation of Genetic Regulatory Systems: A Literature Review , 2002, J. Comput. Biol..

[3]  K. Aihara,et al.  Synchronization of coupled nonidentical genetic oscillators , 2006, Physical biology.

[4]  Kazuyuki Aihara,et al.  Modeling genetic switches with positive feedback loops. , 2003, Journal of theoretical biology.

[5]  Shengyuan Xu,et al.  Stability analysis of delayed genetic regulatory networks with stochastic disturbances , 2009 .

[6]  Song Zheng,et al.  Impulsive synchronization of complex networks with non-delayed and delayed coupling , 2009 .

[8]  V. Lakshmikantham,et al.  Theory of Impulsive Differential Equations , 1989, Series in Modern Applied Mathematics.

[9]  Jitao Sun,et al.  Stability analysis of nonlinear stochastic differential delay systems under impulsive control , 2010 .

[10]  K. Aihara,et al.  Stability of genetic regulatory networks with time delay , 2002 .

[11]  Ruiqi Wang,et al.  Modelling periodic oscillation of biological systems with multiple timescale networks. , 2004, Systems biology.

[12]  Kok Lay Teo,et al.  Stabilizability of discrete chaotic systems via unified impulsive control , 2009 .

[13]  J. Collins,et al.  Construction of a genetic toggle switch in Escherichia coli , 2000, Nature.

[14]  M. Elowitz,et al.  A synthetic oscillatory network of transcriptional regulators , 2000, Nature.

[15]  Jeff Hasty,et al.  Engineered gene circuits , 2002, Nature.

[16]  D. Endy Foundations for engineering biology , 2005, Nature.

[17]  Konstantin B. Blyuss,et al.  Stability and bifurcations in a model of antigenic variation in malaria , 2009, Journal of mathematical biology.

[18]  Jinde Cao,et al.  Asymptotic and robust stability of genetic regulatory networks with time-varying delays , 2008, Neurocomputing.

[19]  E. Davidson,et al.  Modeling transcriptional regulatory networks. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.