论文信息 - Rhodium(I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines.

Rhodium(I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines.

[reaction: see text] A novel strategy for the preparation of seven-membered heterocyclic compounds has been realized. Treatment of ene-allene 1 with a catalytic quantity of rhodium biscarbonyl chloride dimer affords the cyclization product 2 in moderate to high yields. The scope and limitations of this new method are currently under investigation, and the results obtained to date are discussed within.

K. Brummond | Hongfeng Chen | Branko Mitasev | Anthony D. Casarez

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