TRAF 4 Promotes TGF-b Receptor Signaling and Drives Breast Cancer Metastasis

Long Zhang,1,6,7 Fangfang Zhou,1,7,* Amaya Garcı́a de Vinuesa,1 Esther M. de Kruijf,2 Wilma E. Mesker,2 Li Hui,3 Yvette Drabsch,1 Yihao Li,1 Andreas Bauer,4 Adrien Rousseau,5 Kelly-Ann Sheppard,3 Craig Mickanin,3 Peter J.K. Kuppen,2 Chris X. Lu,3 and Peter ten Dijke1,* 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics 2Department of Surgery Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands 3Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA 4Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland 5Institut de Génétique et de Biologie Moléculaire et Cellulaire, Unité Mixte de Recherche 7104, Centre National de la Recherche Scientifique/U964 Institut National de Santé et de Recherche Médicale/Université de Strasbourg, 67404 Illkirch, France 6Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China 7These authors contributed equally to this work *Correspondence: f.zhou@lumc.nl (F.Z.), p.ten_dijke@lumc.nl (P.t.D.) http://dx.doi.org/10.1016/j.molcel.2013.07.014

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