Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children

In this study we used near-infrared spectroscopy (NIRS) to measure relative changes in cortical hemodynamics from 19 adult and 19 preschool children (aged 3-4 years old), while they watched epochs of static and motion pictures extracted from TV programs. The spatio-temporal characteristics of oxygenated and deoxygenated hemoglobin volumes (oxy- and deoxy-Hb) of both subject groups were described and compared where appropriate for five regions of interest (ROIs). These were striate, left and right middle temporal, and left and right temporo-parietal areas. Over these areas, deoxy-Hb volumes did not differ between both groups. Preschool data showed significant increases in oxy-Hb over striate, middle temporal and temporo-parietal areas in response to visual motion stimuli. Static stimuli caused a significant oxy-Hb increase over striate and left middle temporal areas. Surprisingly, changes in adult oxy-Hb were not profound and did not show a significant oxy-Hb increase in striate and middle temporal areas in response to the motion stimuli, warranting further research. In spite of oxy-Hb volume differences, oxy-Hb recovery to baseline followed a similar pattern in both groups in response to both static and motion stimuli. Together, the results suggest that near-infrared spectroscopy is a viable method to investigate cortical development of preschool children by monitoring their hemodynamic response patterns.

[1]  P. Jakobsson,et al.  Fourier-analysed Steady-state VEPs in Pre-school Children with and without Normal Binocularity , 2005, Documenta Ophthalmologica.

[2]  A. Dale,et al.  Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Ann-Christine Ehlis,et al.  Model-based analysis of rapid event-related functional near-infrared spectroscopy (NIRS) data: A parametric validation study , 2007, NeuroImage.

[4]  Elizabeth S. Nilsen,et al.  The relations between children’s communicative perspective-taking and executive functioning , 2009, Cognitive Psychology.

[5]  P. Sinha,et al.  Functional neuroanatomy of biological motion perception in humans , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Kazuo Hiraki,et al.  Neural origin of cognitive shifting in young children , 2009, Proceedings of the National Academy of Sciences.

[7]  Caren M. Walker,et al.  Mental state attribution and the temporoparietal junction: An fMRI study comparing belief, emotion, and perception , 2010, Neuropsychologia.

[8]  H. Hayne,et al.  Age-related changes in verbal and nonverbal memory during early childhood. , 2003, Developmental psychology.

[9]  Willard B. Wong,et al.  Osteology of the Pediatric Skull: Considerations of Halo Pin Placement , 1994, Spine.

[10]  Masako Okamoto,et al.  Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international 10–20 system oriented for transcranial functional brain mapping , 2004, NeuroImage.

[11]  Ingram Wright.  The development of representation in children with Down's syndrome. , 1998 .

[12]  David A. Boas,et al.  Assessing infants' cortical response to speech using near-infrared spectroscopy , 2007, NeuroImage.

[13]  Stephen R. Burgess,et al.  Development of emergent literacy and early reading skills in preschool children: evidence from a latent-variable longitudinal study. , 2000, Developmental psychology.

[14]  Richard N Aslin,et al.  Near-infrared spectroscopy for functional studies of brain activity in human infants: promise, prospects, and challenges. , 2005, Journal of biomedical optics.

[15]  Janette Atkinson,et al.  Regional Hemodynamic Responses to Visual Stimulation in Awake Infants , 1998, Pediatric Research.

[16]  Shozo Kojima,et al.  Motion illusion activates the visual motion area of the brain: A near-infrared spectroscopy (NIRS) study , 2006, Brain Research.

[17]  Janine D. Mendola,et al.  fMRI Measures of Perceptual Filling-in in the Human Visual Cortex , 2006 .

[18]  G. Taga,et al.  Brain imaging in awake infants by near-infrared optical topography , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  A. Maki,et al.  Activation of the visual cortex imaged by 24-channel near-infrared spectroscopy. , 2000, Journal of biomedical optics.

[20]  T. Wilcox,et al.  Using near-infrared spectroscopy to assess neural activation during object processing in infants. , 2005, Journal of biomedical optics.

[21]  C. Sato,et al.  Reevaluation of near-infrared light propagation in the adult human head: implications for functional near-infrared spectroscopy. , 2005, Journal of biomedical optics.

[22]  Jon Baio,et al.  Examination of the Time Between First Evaluation and First Autism Spectrum Diagnosis in a Population-based Sample , 2006, Journal of developmental and behavioral pediatrics : JDBP.

[23]  A. Kaufman,et al.  Review Article: Introduction to the Kaufman Assessment Battery for Children (K-ABC) for Pediatric Neuroclinicians , 1987, Journal of child neurology.

[24]  D. Povinelli,et al.  Development of young children's understanding that the recent past is causally bound to the present. , 1999, Developmental psychology.

[25]  Teresa Wilcox,et al.  Hemodynamic changes in the infant cortex during the processing of featural and spatiotemporal information , 2009, Neuropsychologia.

[26]  M. Botte,et al.  Osteology of the Skull as It Affects Halo Pin Placement , 1985, Spine.

[27]  Ann Dowker,et al.  What can functional brain imaging studies tell us about typical and atypical cognitive development in children? , 2006, Journal of Physiology-Paris.

[28]  Ernst Martin,et al.  The Influence of Cortical Maturation on the BOLD Response: An fMRI Study of Visual Cortex in Children , 2004, Pediatric Research.

[29]  Ruth A. Carper,et al.  Longitudinal Magnetic Resonance Imaging Study of Cortical Development through Early Childhood in Autism , 2010, The Journal of Neuroscience.

[30]  J. Deloache.  The development of representation in young children. , 1989, Advances in child development and behavior.

[31]  F. Liégeois,et al.  Picture Naming in Young Children: A Developmental Study on Interhemispheric Collaboration , 2002, Brain and Cognition.

[32]  Elizabeth Redcay,et al.  fMRI during natural sleep as a method to study brain function during early childhood , 2007, NeuroImage.

[33]  Yoko Hoshi,et al.  Functional near-infrared spectroscopy: current status and future prospects. , 2007, Journal of biomedical optics.

[34]  M. Tomasello,et al.  Modeling children's early grammatical knowledge , 2009, Proceedings of the National Academy of Sciences.

[35]  Gina Conti-Ramsden,et al.  Children's grammatical categories of verb and noun: a comparative look at children with specific language impairment (SLI) and normal language (NL). , 2002, International journal of language & communication disorders.

[36]  Yumiko Otsuka,et al.  Neural activation to upright and inverted faces in infants measured by near infrared spectroscopy , 2007, NeuroImage.

[37]  K. Sakatani,et al.  Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy. , 1999, Early human development.

[38]  F. Jöbsis.  Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.