The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage

[1]  Hai-Hui Xue,et al.  Tcf1 at the crossroads of CD4+ and CD8+ T cell identity , 2017, Frontiers in Biology.

[2]  Changya Chen,et al.  CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. , 2016, Immunity.

[3]  O. Ohara,et al.  Protective neutralizing influenza antibody response in the absence of T follicular helper cells , 2016, Nature Immunology.

[4]  Sandra P. Calderon-Copete,et al.  T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. , 2016, Immunity.

[5]  Di Wu,et al.  CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles , 2016, Nature Immunology.

[6]  Matheus C. Bürger,et al.  Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy , 2016, Nature.

[7]  Ting Ni,et al.  Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection , 2016, Nature.

[8]  Chen Zeng,et al.  Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity , 2016, Nature Immunology.

[9]  T. Speed,et al.  A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet , 2016, Nature Immunology.

[10]  P. Schwartzberg,et al.  TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. , 2015, Cell reports.

[11]  Weiqun Peng,et al.  LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 , 2015, Nature Immunology.

[12]  Xia Yang,et al.  The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection , 2015, Nature Immunology.

[13]  E. Wherry,et al.  Molecular and cellular insights into T cell exhaustion , 2015, Nature Reviews Immunology.

[14]  John T. Chang,et al.  Molecular regulation of effector and memory T cell differentiation , 2014, Nature Immunology.

[15]  S. Crotty.  T follicular helper cell differentiation, function, and roles in disease. , 2014, Immunity.

[16]  Y. Belkaid,et al.  A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells , 2014, Nature Immunology.

[17]  M. Huber,et al.  Heterogeneity in the Differentiation and Function of CD8+ T Cells , 2014, Archivum Immunologiae et Therapiae Experimentalis.

[18]  Farrah C. Steinke,et al.  From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells , 2014, Immunologic Research.

[19]  Jun Zhu,et al.  TCF-1 and LEF-1 act upstream of Th-POK to promote CD4+ T cell lineage choice and cooperate with Runx3 to silence the Cd4 gene in CD8+ T cells , 2014, Nature Immunology.

[20]  G. Friedlander,et al.  Runx3-mediated Transcriptional Program in Cytotoxic Lymphocytes , 2013, PloS one.

[21]  D. Tarlinton,et al.  Diversity Among Memory B Cells: Origin, Consequences, and Utility , 2013, Science.

[22]  E. Yang,et al.  Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation , 2013, Nature Immunology.

[23]  M. Jenkins,et al.  Heterogeneity in the differentiation and function of memory B cells. , 2012, Trends in immunology.

[24]  Susan M. Kaech,et al.  Transcriptional control of effector and memory CD8+ T cell differentiation , 2012, Nature Reviews Immunology.

[25]  B. Langmead,et al.  Aligning Short Sequencing Reads with Bowtie , 2010, Current protocols in bioinformatics.

[26]  J. Harty,et al.  Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. , 2010, Immunity.

[27]  G. Natoli.  Maintaining cell identity through global control of genomic organization. , 2010, Immunity.

[28]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[29]  Kyewon Park,et al.  The role of ThPOK in control of CD4/CD8 lineage commitment. , 2010, Annual review of immunology.

[30]  W. Paul,et al.  Differentiation of effector CD4 T cell populations (*). , 2010, Annual review of immunology.

[31]  J. Harty,et al.  Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells , 2009, The Journal of Immunology.

[32]  E. Meffre,et al.  Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. , 2009, Immunity.

[33]  Chen Zeng,et al.  A clustering approach for identification of enriched domains from histone modification ChIP-Seq data , 2009, Bioinform..

[34]  Mikael Bodén,et al.  MEME Suite: tools for motif discovery and searching , 2009, Nucleic Acids Res..

[35]  Lior Pachter,et al.  Sequence Analysis , 2020, Definitions.

[36]  Nathaniel D. Heintzman,et al.  Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.

[37]  D. Littman,et al.  RUNX proteins in transcription factor networks that regulate T-cell lineage choice , 2009, Nature Reviews Immunology.

[38]  A. Rao,et al.  Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs , 2009, The Journal of experimental medicine.

[39]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[40]  Dong-mei Zhao,et al.  GABPβ2 Is Dispensible for Normal Lymphocyte Development but Moderately Affects B Cell Responses* , 2008, Journal of Biological Chemistry.

[41]  E. Wherry,et al.  Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin , 2008, Science.

[42]  Aviva Petrie,et al.  T testing the immune system. , 2008, Immunity.

[43]  I. Taniuchi,et al.  Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development , 2008, Science.

[44]  John T. Harty,et al.  Shaping and reshaping CD8+ T-cell memory , 2008, Nature Reviews Immunology.

[45]  E. Wherry,et al.  Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. , 2007, Immunity.

[46]  D. Littman,et al.  Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer , 2007, The Journal of experimental medicine.

[47]  R. E. Tillman,et al.  The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells , 2007, The Journal of experimental medicine.

[48]  S. Nutt,et al.  Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance , 2006, Nature Immunology.

[49]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[50]  Jeff F. Miller,et al.  Compartmentalization of Bacterial Antigens: Differential Effects on Priming of CD8 T Cells and Protective Immunity , 1998, Cell.

[51]  W. Paul,et al.  Differentiation of Effector CD 4 T Cell Populations ∗ , 2014 .

[52]  W. Ellmeier,et al.  Transcriptional and epigenetic regulation of CD4/CD8 lineage choice. , 2011, Advances in immunology.

[53]  A. Rao,et al.  Runx 3 and T-box proteins cooperate to establish the transcriptional program of eff ector CTLs , 2009 .

[54]  A. Rao,et al.  Regulation of gene expression in peripheral T cells by Runx transcription factors. , 2009, Advances in immunology.