Aptamer-functionalized nanomaterials for biological applications

Aptamers have attracted the attention of many researchers because of their high stability, high affinity and high selectivity. Over the past decades, considerable intensive exploration and research has been carried out in this area. These studies have led to the emergence of functionalized nanomaterials, which have suggested a more diverse range of potential applications. However, despite the many exciting and remarkable developments emerging at the moment, several challenges and issues remain to be addressed. Based on currently reported aptamer-functionalized nanomaterials (AFNs), this review highlights potential applications for AFN platforms in catalysis, detection, cellular analysis, imaging, and targeted drug delivery. We also focus on explaining controllable syntheses and the unique dynamic properties of AFNs. Finally, we discuss progress and the challenges associated with AFN applications in this field.

[1]  E. Wang,et al.  Multifunctional near-infrared fluorescent nanoclusters for simultaneous targeted cancer imaging and photodynamic therapy , 2016 .

[2]  P. Opanasopit,et al.  Effect of hydrophobic tails of plier-like cationic lipids on nucleic acid delivery and intracellular trafficking. , 2019, International journal of pharmaceutics.

[3]  Y. Sone,et al.  Structures and Antitumor Activities of the Polysaccharides Isolated from Fruiting Body and the Growing Culture of Mycelium of Ganoderma lucidum , 1985 .

[4]  A. Shukla,et al.  Biomaterials for Interfacing Cell Imaging and Drug Delivery: An Overview. , 2019, Langmuir : the ACS journal of surfaces and colloids.

[5]  J. Szostak,et al.  In vitro selection of RNA molecules that bind specific ligands , 1990, Nature.

[6]  M. Sundaralingam,et al.  Analysis of the possible helical structures of nucleic acids and polynucleotides. Application of (n-h) plots. , 1976, Nucleic acids research.

[7]  B. Mukherjee,et al.  Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes , 2020, Molecular therapy. Nucleic acids.

[8]  B. D. Malhotra,et al.  An impedimetric biosensor based on electrophoretically assembled ZnO nanorods and carboxylated graphene nanoflakes on an indium tin oxide electrode for detection of the DNA of Escherichia coli O157:H7 , 2019, Microchimica Acta.

[9]  Wentao Xu,et al.  Colorimetric detection and typing of E. coli lipopolysaccharides based on a dual aptamer-functionalized gold nanoparticle probe , 2019, Microchimica Acta.

[10]  Tianming Yao,et al.  A universal label-free fluorescent aptasensor based on Ru complex and quantum dots for adenosine, dopamine and 17β-estradiol detection. , 2016, Biosensors & bioelectronics.

[11]  W. Guo,et al.  Multifunctional Poly‐N‐Isopropylacrylamide/DNAzyme Microgels as Highly Efficient and Recyclable Catalysts for Biosensing , 2018 .

[12]  E. Wang,et al.  G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugates for targeted cancer cell photodynamic therapy , 2016 .

[13]  Yi Xiao,et al.  Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin. , 2004, Journal of the American Chemical Society.

[14]  Haruki Nakamura,et al.  H3‐rules: identification of CDR‐H3 structures in antibodies , 1999, FEBS letters.

[15]  Zepei Wu,et al.  Interface interaction of MoS2 nanosheets with DNA based aptameric biosensor for carbohydrate antigen 15–3 detection , 2020 .

[16]  Zhike He,et al.  Organic-inorganic nanoflowers: from design strategy to biomedical applications. , 2019, Nanoscale.

[17]  Rui Hu,et al.  A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots. , 2012, Nature nanotechnology.

[18]  Kemin Wang,et al.  ATP-responsive controlled release system using aptamer-functionalized mesoporous silica nanoparticles. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[19]  O. N. Oliveira,et al.  Nanomaterials for diagnosis: challenges and applications in smart devices based on molecular recognition. , 2014, ACS applied materials & interfaces.

[20]  S. G. Harroun,et al.  Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection , 2016 .

[21]  Xiaoling Zhang,et al.  An aptamer cross-linked hydrogel as a colorimetric platform for visual detection. , 2010, Angewandte Chemie.

[22]  H. Chung,et al.  Nanomaterials for cancer therapy and imaging , 2011, Molecules and cells.

[23]  Anthony D. Keefe,et al.  SELEX with modified nucleotides. , 2008, Current opinion in chemical biology.

[24]  Jian Shen,et al.  Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles. , 2019, Analytica chimica acta.

[25]  Miqin Zhang,et al.  Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. , 2010, Advanced drug delivery reviews.

[26]  Giuseppe Maruccio,et al.  A multipurpose biochip for food pathogen detection , 2016 .

[27]  K. Gobi,et al.  A review on recent developments in optical and electrochemical aptamer-based assays for mycotoxins using advanced nanomaterials , 2019, Microchimica Acta.

[28]  Guodong Liu,et al.  Aptamer-functionalized gold nanoparticles as probes in a dry-reagent strip biosensor for protein analysis. , 2009, Analytical chemistry.

[29]  Wei Qian,et al.  Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: a potential cancer diagnostic marker. , 2007, Nano letters.

[30]  Raffaele Conte,et al.  Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells , 2020, International journal of molecular sciences.

[31]  Hua Zhou,et al.  Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic , 2019, Microchimica Acta.

[32]  Julián Valero,et al.  Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure. , 2017, Journal of the American Chemical Society.

[33]  Wen-he Wu,et al.  Aptasensors for rapid detection of Escherichia coli O157:H7 and Salmonella typhimurium , 2012, Nanoscale Research Letters.

[34]  Itamar Willner,et al.  Self-assembly of luminescent Ag nanocluster-functionalized nanowires. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[35]  E. Wang,et al.  DNA G-quadruplex-templated formation of the fluorescent silver nanocluster and its application to bioimaging. , 2012, Talanta.

[36]  Huihui Wang,et al.  Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging. , 2019, Angewandte Chemie.

[37]  Peixuan Guo,et al.  Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles. , 2017, ACS nano.

[38]  F. Tseng,et al.  Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics , 2009 .

[39]  Félix Sancenón,et al.  Selective Fluorogenic Sensing of As(III) Using Aptamer-Capped Nanomaterials. , 2017, ACS applied materials & interfaces.

[40]  W. Tan,et al.  Aptamer-nanoparticle assembly for logic-based detection. , 2012, ACS applied materials & interfaces.

[41]  Yuan Liu,et al.  Aptasensors for pesticide detection. , 2019, Biosensors & bioelectronics.

[42]  Yaping Tian,et al.  Visual detection of kanamycin with DNA-functionalized gold nanoparticles probe in aptamer-based strip biosensor. , 2019, Analytical biochemistry.

[43]  L. Gold,et al.  Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.

[44]  N. Kotov,et al.  Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications. , 2017, Chemical reviews.

[45]  R. John,et al.  Protein functionalized carbon nanotubes-based smart lab-on-a-chip. , 2015, ACS applied materials & interfaces.

[46]  W. Guo,et al.  Regulation of Catalytic DNA Activities with Thermosensitive Gold Nanoparticle Surfaces. , 2018, Langmuir : the ACS journal of surfaces and colloids.

[47]  Baoxin Li,et al.  A sensitive, label-free, aptamer-based biosensor using a gold nanoparticle-initiated chemiluminescence system. , 2011, Chemistry.

[48]  Ping Wang,et al.  In-situ detection of cadmium with aptamer functionalized gold nanoparticles based on smartphone-based colorimetric system. , 2020, Talanta.

[49]  A. Velázquez‐Campoy,et al.  Spatial arrangement of LD motif-interacting residues on focal adhesion targeting domain of Focal Adhesion Kinase determine domain-motif interaction affinity and specificity. , 2020, Biochimica et biophysica acta. General subjects.

[50]  E. A. Sykes,et al.  The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles , 2018, Nano Research.

[51]  K. Abnous,et al.  Improvement in the drug delivery and anti-tumor efficacy of PEGylated liposomal doxorubicin by targeting RNA aptamers in mice bearing breast tumor model. , 2016, Colloids and surfaces. B, Biointerfaces.

[52]  Optical aptasensor based on silver nanoparticles for the colorimetric detection of adenosine. , 2019, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[53]  K. Thompson,et al.  Pharmacokinetics and Biodistribution of Novel Aptamer Compositions , 2004, Pharmaceutical Research.

[54]  John G. Bruno,et al.  Aptamers in the Therapeutics and Diagnostics Pipelines , 2018, Theranostics.

[55]  Arun Richard Chandrasekaran,et al.  Rationally Engineered Nucleic Acid Architectures for Biosensing Applications. , 2019, Chemical reviews.

[56]  Maria C. DeRosa,et al.  Challenges and Opportunities for Small Molecule Aptamer Development , 2012, Journal of nucleic acids.

[57]  V. C. Moore,et al.  Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes , 2002, Science.

[58]  Weihong Tan,et al.  Immobilization of oligonucleotides onto silica nanoparticles for DNA hybridization studies , 2002 .

[59]  Pu Zhang,et al.  Detection of B-type natriuretic peptide by establishing a low-cost and replicable fluorescence resonance energy transfer platform , 2020, Microchimica Acta.

[60]  Chia-Chen Chang,et al.  Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications , 2019, Nanomaterials.

[61]  Peng Miao,et al.  Highly Sensitive Endotoxin Assay Combining Peptide/Graphene Oxide and DNA-Modified Gold Nanoparticles , 2019, ACS omega.

[62]  Tao Li,et al.  Ion-tuned DNA/Ag fluorescent nanoclusters as versatile logic device. , 2011, ACS nano.

[63]  C. Niemeyer.  REVIEW Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science , 2022 .

[64]  Kemin Wang,et al.  Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers. , 2003, Analytical chemistry.

[65]  Liang Yan,et al.  A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines , 2019, Advanced materials.

[66]  Bryan Wei,et al.  Aptamer based reversible DNA induced hydrogel system for molecular recognition and separation. , 2010, Chemical communications.

[67]  Ronghua Yang,et al.  Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization. , 2008, Journal of the American Chemical Society.

[68]  Robert Langer,et al.  Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures , 2017, Expert opinion on drug delivery.

[69]  Jong-Hyun Lee,et al.  Immobilized DNA aptamers used as potent attractors for vascular endothelial cell: in vitro study of female rat , 2020, Bioscience reports.

[70]  P. Rai,et al.  Cancer nanomedicine: a review of recent success in drug delivery , 2017, Clinical and Translational Medicine.

[71]  A M Gronenborn,et al.  Determining the structures of large proteins and protein complexes by NMR. , 1998, Trends in biotechnology.

[72]  M. Ganjali,et al.  Fluorescent apta-nanobiosensors for fast and sensitive detection of digoxin in biological fluids using rGQDs: Comparison of two approaches for immobilization of aptamer , 2020 .

[73]  Jian-Rong Zhang,et al.  One-pot synthesis of aptamer-functionalized silver nanoclusters for cell-type-specific imaging. , 2012, Analytical chemistry.

[74]  A. Baeumner,et al.  Functional Nanomaterials and Nanostructures Enhancing Electrochemical Biosensors and Lab-on-a-Chip Performances: Recent Progress, Applications, and Future Perspective. , 2018, Chemical reviews.

[75]  Jun Ai,et al.  A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery , 2018 .

[76]  Yi Lu,et al.  Smart “Turn‐on” Magnetic Resonance Contrast Agents Based on Aptamer‐Functionalized Superparamagnetic Iron Oxide Nanoparticles , 2007, Chembiochem : a European journal of chemical biology.

[77]  Zhuang Liu,et al.  PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. , 2008, Journal of the American Chemical Society.

[78]  B. Mukherjee,et al.  A Comparative Investigation of the Ability of Various Aptamer-Functionalized Drug Nanocarriers to Induce Selective Apoptosis in Neoplastic Hepatocytes: In Vitro and In Vivo Outcome , 2020, AAPS PharmSciTech.

[79]  Hoi Man Leung,et al.  A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. , 2016, Nanoscale.

[80]  Yi Lu,et al.  Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications. , 2019, Accounts of chemical research.

[81]  Yi Lu,et al.  Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor. , 2004, Analytical chemistry.

[82]  P. A. Fiorito,et al.  Synthesis, characterization and immobilization of Prussian blue nanoparticles. A potential tool for biosensing devices. , 2005, Chemical communications.

[83]  R. Dinarvand,et al.  Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents , 2019, Pharmaceutical development and technology.

[84]  J. Rossi,et al.  Aptamers as targeted therapeutics: current potential and challenges , 2016, Nature Reviews Drug Discovery.

[85]  S. M. Taghdisi,et al.  Triple-helix molecular switch-based aptasensors and DNA sensors. , 2018, Biosensors & bioelectronics.

[86]  Kemin Wang,et al.  Beyond native deoxyribonucleic acid, templating fluorescent nanomaterials for bioanalytical applications: A review. , 2020, Analytica chimica acta.

[87]  T. Chandy.  Biocompatibility of materials and its relevance to drug delivery and tissue engineering , 2020, Biointegration of Medical Implant Materials.

[88]  Chih-Ching Huang,et al.  Aptamer-Functionalized Nano-Biosensors , 2009, Sensors.

[89]  Peng Huang,et al.  An aptamer-targeting photoresponsive drug delivery system using "off-on" graphene oxide wrapped mesoporous silica nanoparticles. , 2015, Nanoscale.

[90]  Jonathan Hall,et al.  High-order structures from nucleic acids for biomedical applications , 2020 .

[91]  Chad A Mirkin,et al.  Nanostructures in biodiagnostics. , 2005, Chemical reviews.

[92]  Guodong Liu,et al.  Aptamer-nanoparticle strip biosensor for sensitive detection of cancer cells. , 2009, Analytical chemistry.

[93]  Young Jik Kwon,et al.  Gold nanocrystals with DNA-directed morphologies , 2016, Nature Communications.

[94]  E. Wang,et al.  Folic acid as delivery vehicles: targeting folate conjugated fluorescent nanoparticles to tumors imaging. , 2012, Talanta.

[95]  X. Le,et al.  Competitive protection of aptamer-functionalized gold nanoparticles by controlling the DNA assembly. , 2011, Analytical chemistry.

[96]  C. Reinemann,et al.  Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment. , 2014, Swiss medical weekly.

[97]  Ming Liu,et al.  Immobilized polymer layers on spherical nanoparticles , 2010 .

[98]  K. Thompson,et al.  Discovery and development of therapeutic aptamers. , 2010, Annual review of pharmacology and toxicology.

[99]  Adam Bolotsky,et al.  Two-Dimensional Materials in Biosensing and Healthcare: from In Vitro Diagnostics to Optogenetics and Beyond. , 2019, ACS nano.

[100]  A. Allan,et al.  Cancer stem cells: implications for the progression and treatment of metastatic disease , 2007, Journal of cellular and molecular medicine.

[101]  Minghua Wang,et al.  Gold nanoparticles conjugated to bimetallic manganese(II) and iron(II) Prussian Blue analogues for aptamer-based impedimetric determination of the human epidermal growth factor receptor-2 and living MCF-7 cells , 2019, Microchimica Acta.

[102]  Jin-Ming Lin,et al.  Multi-DNAzymes-functionalized gold nanoparticles for ultrasensitive chemiluminescence detection of thrombin on microchip. , 2018, Analytica chimica acta.

[103]  Yi Du,et al.  DNA Logic Operations in Living Cells Utilizing Lysosome-Recognizing Framework Nucleic Acid Nanodevices for Subcellular Imaging. , 2019, ACS nano.

[104]  Rajni Bala,et al.  Detection of organophosphorus pesticide – Malathion in environmental samples using peptide and aptamer based nanoprobes , 2017 .

[105]  Xiya Zhang,et al.  Development of a highly specific chemiluminescence aptasensor for sulfamethazine detection in milk based on in vitro selected aptamers , 2019, Sensors and Actuators B: Chemical.

[106]  Huanhuan Li,et al.  Fluorometric determination of lead(II) by using aptamer-functionalized upconversion nanoparticles and magnetite-modified gold nanoparticles , 2020, Microchimica Acta.

[107]  Ronghua Yang,et al.  Nucleic acid conjugated nanomaterials for enhanced molecular recognition. , 2009, ACS nano.

[108]  Kurt V Gothelf,et al.  Chemistries for DNA Nanotechnology. , 2019, Chemical reviews.