The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation.

[1]  J. Deadman,et al.  Assembly of urokinase receptor-mediated plasminogen activation complexes involves direct, non-active-site interactions between urokinase and plasminogen. , 1999, Biochemistry.

[2]  D. Zhu,et al.  Analysis of the forces which stabilize the active conformation of urokinase-type plasminogen activator. , 1998, Biochemistry.

[3]  M. Newman,et al.  epsilon-Aminocaproic Acid Plasma Levels During Cardiopulmonary Bypass , 1997, Anesthesia and analgesia.

[4]  D. Cines,et al.  Regulation of single chain urokinase by small peptides. , 1996, Thrombosis Research.

[5]  P. Sarmientos,et al.  A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity. , 1996, Biochemistry.

[6]  G. Markus Conformational changes in plasminogen, their effect on activation, and the agents that modulate activation rates — a review , 1996 .

[7]  K. Kolev,et al.  Dual effect of synthetic plasmin substrates on plasminogen activation. , 1995, Biochimica et biophysica acta.

[8]  J. Weisel,et al.  Interactions of plasminogen with polymerizing fibrin and its derivatives, monitored with a photoaffinity cross-linker and electron microscopy. , 1994, Journal of molecular biology.

[9]  K. Danø,et al.  Specific inhibition of the activity of the urokinase receptor-mediated cell-surface plasminogen activation system by suramin. , 1993, The Biochemical journal.

[10]  V. Gurewich,et al.  The kinetics of plasminogen activation by thrombin-cleaved pro-urokinase and promotion of its activity by fibrin fragment E-2 and by tissue plasminogen activator. , 1993, Blood.

[11]  C. Ponting,et al.  Plasminogen: a structural review. , 1992, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[12]  Jian-ning Liu,et al.  Fragment E-2 from fibrin substantially enhances pro-urokinase-induced Glu-plasminogen activation. A kinetic study using the plasmin-resistant mutant pro-urokinase Ala-158-rpro-UK. , 1992, Biochemistry.

[13]  V. Gurewich,et al.  The effect of the carboxy-terminal lysine of urokinase on the catalysis of plasminogen activation. , 1991, Thrombosis research.

[14]  W. Mangel,et al.  Characterization of an extremely large, ligand-induced conformational change in plasminogen. , 1990, Science.

[15]  M. Scully,et al.  Activation of pro-urokinase by plasmin: non-Michaelian kinetics indicates a mechanism of negative cooperativity. , 1989, Archives of biochemistry and biophysics.

[16]  U. Christensen Urokinase-catalysed plasminogen activation. Effects of ligands binding to the AH-site of plasminogen. , 1988, Biochimica et biophysica acta.

[17]  F. Castellino,et al.  The activation of human [Glu1]plasminogen by human single-chain urokinase , 1988 .

[18]  B. Binder,et al.  Plasminogen activation by tissue plasminogen activator in the presence of stimulating CNBr fragment FCB-2 of fibrinogen is a two-phase reaction. Kinetic analysis of the initial phase of slow plasmin formation. , 1988, The Journal of biological chemistry.

[19]  P. Privalov,et al.  Domains in human plasminogen. , 1984, Journal of molecular biology.

[20]  P. McKee,et al.  The effects of fibrinogen and its cleavage products on the kinetics of plasminogen activation by urokinase and subsequent plasmin activity. , 1983, The Journal of biological chemistry.

[21]  P. McKee,et al.  The binding of human plasminogen to fibrin and fibrinogen. , 1983, The Journal of biological chemistry.

[22]  M. Rånby,et al.  Studies on the kinetics of plasminogen activation by tissue plasminogen activator. , 1982, Biochimica et biophysica acta.

[23]  S. Peltz,et al.  Positive regulation of activation of plasminogen by urokinase: differences in Km for (glutamic acid)-plasminogen and lysine-plasminogen and effect of certain alpha, omega-amino acids. , 1982, Biochemistry.

[24]  W. Gunzler The primary structure of high molecular mass urokinase from human urine , 1982 .

[25]  F. Castellino,et al.  [29] Human plasminogen , 1981 .

[26]  R. Priore,et al.  The binding of tranexamic acid to native (Glu) and modified (Lys) human plasminogen and its effect on conformation. , 1979, The Journal of biological chemistry.

[27]  G. Markus,et al.  Quantitative determination of the binding of epsilon-aminocaproic acid to native plasminogen. , 1978, The Journal of biological chemistry.

[28]  S. Thorsen Differences in the binding to fibrin of native plasminogen and plasminogen modified by proteolytic degradation. Influence of omega-aminocarboxylic acids. , 1975, Biochimica et biophysica acta.

[29]  S. Thorsen,et al.  Rate of activation and electrophoretic mobility of unmodified and partially degraded plasminogen. Effects of 6-aminohexanoic acid and related compounds. , 1974, Scandinavian journal of clinical and laboratory investigation.

[30]  J. Vermylen,et al.  Physico-chemical and proenzyme properties of NH2-terminal glutamic acid and NH2-terminal lysine human plasminogen. Influence of 6-aminohexanoic acid. , 1974, Biochimica et biophysica acta.

[31]  M. Olson,et al.  The effect of depletion of endogenous substrates on the metabolic behavior of isolated rabbit heart mitochondria. , 1967, The Journal of biological chemistry.