Involvement of multiple cytochrome p450 isoforms in naproxen demethylation

[1]  R. Tukey,et al.  Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen. , 1996, Biochemical pharmacology.

[2]  S. Wrighton,et al.  Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. , 1995, Biochemical pharmacology.

[3]  H. Yamazaki,et al.  Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. , 1994, The Journal of pharmacology and experimental therapeutics.

[4]  D. Waxman,et al.  Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. , 1994, Archives of biochemistry and biophysics.

[5]  J. Miners,et al.  Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9. , 1991, Biochemical and biophysical research communications.

[6]  A. Boobis,et al.  Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. , 1990, British journal of clinical pharmacology.

[7]  O. Pelkonen,et al.  The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. , 1986, British journal of clinical pharmacology.

[8]  P. Watkins,et al.  Identification of an inducible form of cytochrome P-450 in human liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Collins,et al.  Urinary metabolic profiles for choosing test animals for chronic toxicity studies: application to naproxen. , 1973, Journal of pharmaceutical sciences.

[10]  T. Omura,et al.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. , 1964, The Journal of biological chemistry.

[11]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[12]  A. D. Rodrigues,et al.  [O-methyl 14C]naproxen O-demethylase activity in human liver microsomes: evidence for the involvement of cytochrome P4501A2 and P4502C9/10. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[13]  T. Leemann,et al.  Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver. , 1993, Life sciences.

[14]  T. Leemann,et al.  In vitro oxidation of oxicam NSAIDS by a human liver cytochrome P450. , 1992, Life sciences.

[15]  T. Aoyama,et al.  Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. , 1992, Chemical research in toxicology.

[16]  F. Gonzalez,et al.  Expression of mammalian cytochrome P450 using vaccinia virus. , 1991, Methods in Enzymology.

[17]  M. Relling,et al.  Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. , 1990, The Journal of pharmacology and experimental therapeutics.

[18]  S. Kushinsky,et al.  Isolation and identification of 6-desmethylnaproxen sulfate as a new metabolite of naproxen in human plasma. , 1989, Drug metabolism and disposition: the biological fate of chemicals.

[19]  H. Sevelius,et al.  Naproxen-metabolism, excretion and comparative pharmacokinetics. , 1973, Scandinavian journal of rheumatology. Supplement.