Imaging of pediatric cerebellar tumors

Abstract Pediatric cerebellar tumors constitute a heterogeneous group of central nervous system neoplasms with very different imaging characteristic, spread patterns, and outcomes. At one end of the spectrum are the pilocytic astroctyomas which have very good prognosis following complete resection. At the other end are the medulloblastomas and atypical teratoid/rhabdoid tumors with relatively poor outcomes. Familiarity with imaging characteristics of these common neoplasms is important in performing the role of the pediatric neuroradiologist. Magnetic resonance spectroscopy and diffusion weighted imaging play important adjuncts to conventional imaging in the diagnosis and follow-up of these tumors.

[1]  Hendrik Witt,et al.  Medulloblastoma comprises four distinct molecular variants. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  J. McComb,et al.  Evaluation of intracranial cerebrospinal fluid cytology in staging pediatric medulloblastomas, supratentorial primitive neuroectodermal tumors, and ependymomas. , 2010, Journal of neurosurgery. Pediatrics.

[3]  David W. Ellison,et al.  Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease , 2010, Acta Neuropathologica.

[4]  M. Song,et al.  Posterior fossa intracranial inflammatory pseudotumor: a case report and literature review. , 2009, Surgical neurology.

[5]  A. J. Barkovich,et al.  Imaging of ependymomas: MRI and CT , 2009, Child's Nervous System.

[6]  J. Biegel,et al.  Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  A. Panigrahy,et al.  Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications , 2009, Pediatric Radiology.

[8]  J. Rutka,et al.  The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children , 2009, Child's Nervous System.

[9]  A. Little,et al.  The management of completely resected childhood intracranial ependymoma: the argument for observation only , 2009, Child's Nervous System.

[10]  U. de Girolami,et al.  Cerebrospinal fluid cytology in patients with ependymoma , 2008, Cancer.

[11]  J. Finlay,et al.  Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors , 2008, Pediatric blood & cancer.

[12]  C. Timmons,et al.  Imaging characteristics of atypical teratoid-rhabdoid tumor in children compared with medulloblastoma. , 2008, AJR. American journal of roentgenology.

[13]  I. Leuschner,et al.  Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany. , 2008, Oncology reports.

[14]  D. Figarella-Branger,et al.  Multiparametric differentiation of posterior fossa tumors in children using diffusion‐weighted imaging and short echo‐time 1H‐MR spectroscopy , 2007, Journal of magnetic resonance imaging : JMRI.

[15]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[16]  Daniel L. A. Camacho,et al.  Apparent diffusion coefficients for differentiation of cerebellar tumors in children. , 2006, AJNR. American journal of neuroradiology.

[17]  J. Rutka,et al.  Imaging findings in primary intracranial atypical teratoid/rhabdoid tumors , 2006, Pediatric Radiology.

[18]  F. Gilles,et al.  Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy. , 2005, Radiology.

[19]  F. Gilles,et al.  Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. , 2005, Neurosurgical focus.

[20]  D. Ellison,et al.  Outcome for patients with metastatic (M2-3) medulloblastoma treated with SIOP/UKCCSG PNET-3 chemotherapy. , 2005, European journal of cancer.

[21]  D. Ho,et al.  Neuroradiological findings in atypical teratoid/rhabdoid tumor of the central nervous system , 2005, Acta radiologica.

[22]  E. Rushing,et al.  From the archives of the AFIP: pilocytic astrocytoma: radiologic-pathologic correlation. , 2004, Radiographics : a review publication of the Radiological Society of North America, Inc.

[23]  R. Mulhern,et al.  Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  B. Scheithauer,et al.  Central nervous system atypical teratoid/rhabdoid tumor: results of therapy in children enrolled in a registry. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  Shih-Ming Jung,et al.  Imaging Predictors of Intracranial Ependymomas , 2004, Journal of computer assisted tomography.

[26]  D. Yousem,et al.  Imaging findings of CNS atypical teratoid/rhabdoid tumors. , 2004, AJNR. American journal of neuroradiology.

[27]  L. Lagae,et al.  MRI findings in acute cerebellitis , 2004, European Radiology.

[28]  C. Diebler,et al.  Paediatric medulloblastoma: Atypical CT features at presentation in the SIOP II trial , 2004, Neuroradiology.

[29]  B. Kendall,et al.  Computed tomography in management of medulloblastomas , 2004, Neuroradiology.

[30]  M. Snuderl,et al.  Pediatric Intracranial Ependymomas: Prognostic Relevance of Histological, Immunohistochemical, and Flow Cytometric Factors , 2003, Modern Pathology.

[31]  D. Ellison,et al.  What's new in neuro-oncology? Recent advances in medulloblastoma. , 2003, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[32]  P. Jabbour,et al.  Hemicerebellitis mimicking a tumour on MRI , 2003, Child's Nervous System.

[33]  C. Sainte-Rose,et al.  Ependymoma in childhood: prognostic factors, extent of surgery, and adjuvant therapy. , 2002, Journal of neurosurgery.

[34]  J. Biegel,et al.  Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System: Report on Workshop , 2002, Journal of pediatric hematology/oncology.

[35]  J. Buatti,et al.  Intracranial Ependymomas: An Analysis of Prognostic Factors and Patterns of Failure , 2002, American journal of clinical oncology.

[36]  A. Goel,et al.  Prognostic Factors for Cerebellar Astrocytomas in Children: A Study of 102 Cases , 2001, Pediatric Neurosurgery.

[37]  M. Brada Pathology and Genetics of Tumours of the Nervous System , 2001, British Journal of Cancer.

[38]  D. Figarella-Branger,et al.  Prognostic factors in intracranial ependymomas in children. , 2000, Journal of neurosurgery.

[39]  R. Zimmerman,et al.  Postoperative evaluation for disseminated medulloblastoma involving the spine: contrast-enhanced MR findings, CSF cytologic analysis, timing of disease occurrence, and patient outcomes. , 2000, AJNR. American journal of neuroradiology.

[40]  L. Palma,et al.  The importance of surgery in supratentorial ependymomas. Long-term survival in a series of 23 cases. , 2000, Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.

[41]  X Xiong,et al.  Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  K. Lamborn,et al.  A multi-institutional retrospective study of intracranial ependymoma in children: identification of risk factors. , 1999, Journal of pediatric hematology/oncology.

[43]  L. Rorke,et al.  Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  W. Maixner,et al.  Benign cerebellar astrocytomas in children. , 1999, Journal of neurosurgery.

[45]  L. Rorke,et al.  Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group. , 1998, Journal of neurosurgery.

[46]  S. Holland,et al.  Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. , 1998, AJNR. American journal of neuroradiology.

[47]  James H. Johnson,et al.  Clinical outcome of pediatric gangliogliomas: ninety-nine cases over 20 years. , 1997, Pediatric neurosurgery.

[48]  M. Carli,et al.  Analyses of prognostic factors in a retrospective review of 92 children with ependymoma: Italian Pediatric Neuro-oncology Group. , 1997, Medical and pediatric oncology.

[49]  A. Wade,et al.  Medulloblastoma: is the 5-year survival rate improving? A review of 80 cases from a single institution. , 1997, Journal of neurosurgery.

[50]  H. Woo,et al.  Disseminated ependymomas of the central nervous system. , 1996, Journal of neurosurgery.

[51]  S. Love,et al.  Intracranial ependymomas: analysis of prognostic factors in a population-based series. , 1996, Pediatric neurosurgery.

[52]  P. Gerszten,et al.  Intracranial ependymomas of childhood: long-term outcome and prognostic factors. , 1995, Neurosurgery.

[53]  T. Olson,et al.  Successful Treatment of Disseminated Central Nervous System Malignant Rhabdoid Tumor , 1995, Journal of pediatric hematology/oncology.

[54]  J. Habrand,et al.  Treatment of intracranial ependymomas of children: review of a 15-year experience. , 1994, International journal of radiation oncology, biology, physics.

[55]  M E Cohen,et al.  Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. , 1993, The New England journal of medicine.

[56]  D. Gusnard,et al.  Proton magnetic resonance spectroscopy of pediatric brain tumors. , 1992, Neurosurgery.

[57]  J. P. Mickle Ganglioglioma in children. A review of 32 cases at the University of Florida. , 1992, Pediatric neurosurgery.

[58]  P. Black,et al.  The prognostic significance of postoperative residual tumor in ependymoma. , 1991, Neurosurgery.

[59]  R. Roberts,et al.  Medulloblastoma: A Population-based Study of 532 Cases , 1991, Journal of neuropathology and experimental neurology.

[60]  D. Harwood-Nash,et al.  Primary neoplasms of the central nervous system in children , 1991, Cancer.

[61]  W. J. Oakes,et al.  False-positive spinal MR findings for subarachnoid spread of primary CNS tumor in postoperative pediatric patients. , 1990, AJNR. American journal of neuroradiology.

[62]  L. Becker,et al.  Infratentorial ependymomas in childhood: prognostic factors and treatment. , 1990, Journal of neurosurgery.

[63]  L. Rorke,et al.  Prognostic factors in childhood ependymomas. , 1990, Pediatric neurosurgery.

[64]  K. Wallner,et al.  Treatment results of juvenile pilocytic astrocytoma. , 1988, Journal of neurosurgery.

[65]  J. Jinkins,et al.  Medulloblastomas: a review of modern management with a report on 75 cases. , 1985, Surgical neurology.

[66]  A. Osborn,et al.  Supratentorial ependymoma: CT appearance. , 1985, Radiology.

[67]  T. Slamovits Von Recklinghausen neurofibromatosis: II. Incidence of optic gliomata. , 1985, Ophthalmology.

[68]  O. Salazar A better understanding of CNS seeding and a brighter outlook for postoperatively irradiated patients with ependymomas. , 1983, International journal of radiation oncology, biology, physics.

[69]  L. Becker,et al.  Medulloblastoma: clinical presentation and management. Experience at the hospital for sick children, toronto, 1950-1980. , 1983, Journal of neurosurgery.