A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms*

Together with seven ADAMTS-like proteins, the 19 mammalian ADAMTS proteases constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose hallmark is an ancillary domain containing one or more thrombospondin type 1 repeats. ADAMTS-like proteins resemble ADAMTS ancillary domains and lack proteolytic activity. Vertebrate expansion of the superfamily reflects emergence of new substrates, duplication of proteolytic activities in new contexts, and cooperative functions of the duplicated genes. ADAMTS proteases are involved in maturation of procollagen and von Willebrand factor, as well as in extracellular matrix proteolysis relating to morphogenesis, angiogenesis, ovulation, cancer, and arthritis. New insights into ADAMTS mechanisms indicate significant regulatory roles for ADAMTS ancillary domains, propeptide processing, and glycosylation. ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix.

[1]  Lauren W. Wang,et al.  Post-translational Modification of Thrombospondin Type-1 Repeats in ADAMTS-like 1/Punctin-1 by C-Mannosylation of Tryptophan* , 2009, The Journal of Biological Chemistry.

[2]  R. Barve,et al.  A review of the ADAMTS family, pharmaceutical targets of the future. , 2009, Current pharmaceutical design.

[3]  D. Quartermain,et al.  C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke. , 2009, Blood.

[4]  C. López-Otín,et al.  Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. , 2009, Cancer research.

[5]  D. Lane,et al.  Essential role of the disintegrin-like domain in ADAMTS13 function. , 2009, Blood.

[6]  Y. Kohara,et al.  C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV , 2009, Development.

[7]  M. Iruela-Arispe,et al.  Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. , 2009, The international journal of biochemistry & cell biology.

[8]  D. McCulloch,et al.  Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. , 2009, Gene expression patterns : GEP.

[9]  S. Leal,et al.  A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. , 2009, American journal of human genetics.

[10]  K. Tamai,et al.  MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans , 2008, Proceedings of the National Academy of Sciences.

[11]  S. Ihara,et al.  Stage‐specific activation of MIG‐17/ADAMTS controls cell migration in Caenorhabditis elegans , 2008, The FEBS journal.

[12]  A. Munnich,et al.  ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation , 2008, Nature Genetics.

[13]  K. Stankunas,et al.  Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. , 2008, Developmental cell.

[14]  W. Pavan,et al.  The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival , 2008, PLoS genetics.

[15]  A. Parker,et al.  Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. , 2007, Journal of molecular biology.

[16]  Lauren W. Wang,et al.  O-Fucosylation of Thrombospondin Type 1 Repeats in ADAMTS-like-1/Punctin-1 Regulates Secretion , 2007, Journal of Biological Chemistry.

[17]  R. Haltiwanger,et al.  O-Fucosylation Is Required for ADAMTS13 Secretion*♦ , 2007, Journal of Biological Chemistry.

[18]  S. Ihara,et al.  Prodomain‐dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans , 2007, The EMBO journal.

[19]  R. Leduc,et al.  Regulation of ADAMTS9 Secretion and Enzymatic Activity by Its Propeptide* , 2007, Journal of Biological Chemistry.

[20]  S. Law,et al.  Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9 , 2007, Oncogene.

[21]  D. Russell,et al.  Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. , 2006, Developmental biology.

[22]  S. Hussain,et al.  Sea urchin metalloproteases: a genomic survey of the BMP-1/tolloid-like, MMP and ADAM families. , 2006, Developmental biology.

[23]  M. Iruela-Arispe,et al.  ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 , 2006, The EMBO journal.

[24]  M. Iruela-Arispe,et al.  Proteolytic cleavage of versican during cardiac cushion morphogenesis , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[25]  M. Taira,et al.  Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity. , 2006, Developmental biology.

[26]  R. Leduc,et al.  Cell-surface Processing of Pro-ADAMTS9 by Furin* , 2006, Journal of Biological Chemistry.

[27]  Y-j Liu,et al.  Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively , 2006, Oncogene.

[28]  K. Powell,et al.  Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis , 2006, Development.

[29]  P. Robinson,et al.  The molecular genetics of Marfan syndrome and related disorders , 2006, Journal of Medical Genetics.

[30]  J. V. Van Beeumen,et al.  Domains and Maturation Processes That Regulate the Activity of ADAMTS-2, a Metalloproteinase Cleaving the Aminopropeptide of Fibrillar Procollagens Types I–III and V* , 2005, Journal of Biological Chemistry.

[31]  K. Lyons,et al.  Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1* , 2005, Journal of Biological Chemistry.

[32]  K. Matsushima,et al.  ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. , 2005, Journal of molecular endocrinology.

[33]  J. Huxley-Jones,et al.  The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family. , 2005, The international journal of biochemistry & cell biology.

[34]  S. Werner,et al.  ADAMTS1 Proteinase Is Up-regulated in Wounded Skin and Regulates Migration of Fibroblasts and Endothelial Cells* , 2005, Journal of Biological Chemistry.

[35]  J. Sadler,et al.  Binding of ADAMTS13 to von Willebrand Factor* , 2005, Journal of Biological Chemistry.

[36]  S. Apte,et al.  Adamts9 is widely expressed during mouse embryo development. , 2005, Gene expression patterns : GEP.

[37]  D. Boerboom,et al.  Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation1 , 2005, Biology of reproduction.

[38]  A. Fourie,et al.  ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro , 2005, Nature.

[39]  H. Ma,et al.  Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis , 2005, Nature.

[40]  I. Kola,et al.  Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis. , 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[41]  S. Apte,et al.  Discovery and Characterization of a Novel, Widely Expressed Metalloprotease, ADAMTS10, and Its Proteolytic Activation* , 2004, Journal of Biological Chemistry.

[42]  K. Nishiwaki,et al.  A Fibulin-1 Homolog Interacts with an ADAM Protease that Controls Cell Migration in C. elegans , 2004, Current Biology.

[43]  Kyung Won Kim,et al.  GON-1 and Fibulin Have Antagonistic Roles in Control of Organ Shape , 2004, Current Biology.

[44]  A. Munnich,et al.  ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome. , 2004, American journal of human genetics.

[45]  J. Sanes,et al.  ADAMTS7B, the Full-length Product of the ADAMTS7 Gene, Is a Chondroitin Sulfate Proteoglycan Containing a Mucin Domain* , 2004, Journal of Biological Chemistry.

[46]  Y. Okada,et al.  ADAMTS4 (Aggrecanase-1) Interaction with the C-terminal Domain of Fibronectin Inhibits Proteolysis of Aggrecan* , 2004, Journal of Biological Chemistry.

[47]  Ping Wang,et al.  Proprotein Convertase Furin Interacts with and Cleaves Pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi Network* , 2004, Journal of Biological Chemistry.

[48]  P. Hertzog,et al.  Adamts-1 Is Essential for the Development and Function of the Urogenital System1 , 2004, Biology of reproduction.

[49]  J. Sandy,et al.  ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1* , 2004, Journal of Biological Chemistry.

[50]  J. Enghild,et al.  Altered Proteolytic Activities of ADAMTS-4 Expressed by C-terminal Processing* , 2004, Journal of Biological Chemistry.

[51]  D. Keene,et al.  Fine tuning of growth factor signals depends on fibrillin microfibril networks. , 2004, Birth defects research. Part C, Embryo today : reviews.

[52]  J. Sadler,et al.  Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity* , 2003, Journal of Biological Chemistry.

[53]  J. McPherson,et al.  A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation , 2003, Development.

[54]  J. Moake,et al.  ADAMTS-13 Metalloprotease Interacts with the Endothelial Cell-derived Ultra-large von Willebrand Factor* , 2003, Journal of Biological Chemistry.

[55]  M. Iruela-Arispe,et al.  ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165* , 2003, Journal of Biological Chemistry.

[56]  R. Leduc,et al.  Characterization of ADAMTS-9 and ADAMTS-20 as a Distinct ADAMTS Subfamily Related to Caenorhabditis elegans GON-1* , 2003, The Journal of Biological Chemistry.

[57]  A. Munnich,et al.  In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome , 2003, Journal of medical genetics.

[58]  E. Lavallie,et al.  Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites* , 2002, The Journal of Biological Chemistry.

[59]  M. Seldin,et al.  Punctin, a Novel ADAMTS-like Molecule, ADAMTSL-1, in Extracellular Matrix* , 2002, The Journal of Biological Chemistry.

[60]  J. V. Van Beeumen,et al.  Cloning and Characterization of ADAMTS-14, a Novel ADAMTS Displaying High Homology with ADAMTS-2 and ADAMTS-3* , 2002, The Journal of Biological Chemistry.

[61]  K. Fujikawa,et al.  Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura* , 2001, The Journal of Biological Chemistry.

[62]  T. Foroud,et al.  Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura , 2001, Nature.

[63]  D. Eyre,et al.  Procollagen II Amino Propeptide Processing by ADAMTS-3 , 2001, The Journal of Biological Chemistry.

[64]  M Kashiwagi,et al.  TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)* , 2001, The Journal of Biological Chemistry.

[65]  B. Maček,et al.  C-Mannosylation and O-Fucosylation of the Thrombospondin Type 1 Module* , 2001, The Journal of Biological Chemistry.

[66]  A. Sieron,et al.  Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. , 2000, Development.

[67]  R. Leduc,et al.  Characterization of METH-1/ADAMTS1 Processing Reveals Two Distinct Active Forms* , 2000, The Journal of Biological Chemistry.

[68]  T. Burn,et al.  The Thrombospondin Motif of Aggrecanase-1 (ADAMTS-4) Is Critical for Aggrecan Substrate Recognition and Cleavage* , 2000, The Journal of Biological Chemistry.

[69]  N. Hisamoto,et al.  A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans. , 2000, Science.

[70]  H. Nishimatsu,et al.  ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. , 2000, The Journal of clinical investigation.

[71]  J. Hodgkin,et al.  The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. , 1999, Developmental biology.

[72]  M. Seldin,et al.  ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases , 1999, The Journal of Biological Chemistry.

[73]  W. Reardon,et al.  Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. , 1999, American journal of human genetics.

[74]  Robert Blelloch,et al.  Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans , 1999, Nature.

[75]  K. Matsushima,et al.  ADAMTS-1 Protein Anchors at the Extracellular Matrix through the Thrombospondin Type I Motifs and Its Spacing Region* , 1998, The Journal of Biological Chemistry.

[76]  K. Matsushima,et al.  Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene* , 1997, The Journal of Biological Chemistry.

[77]  B. Nusgens,et al.  Ehlers-Danlos type VII-C, or human dermatosparaxis. The offspring of a union between basic and clinical research. , 1993, Archives of dermatology.

[78]  K. Kivirikko,et al.  Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen. , 1978, Biochemistry.