Centers for Cardiovascular Outcomes Research: Defining a Collaborative Vision

Background—Recognizing the value of outcomes research to understand and bridge translational gaps, to establish evidence in clinical practice and delivery of medicine, and to generate new hypotheses on ongoing questions of treatment and care, the National Heart, Lung, and Blood Institute of the National Institutes of Health established the Centers for Cardiovascular Outcomes Research program in 2010. Methods and Results—The National Heart, Lung, and Blood Institute funded 3 centers and a research coordinating unit. Each center has an independent project focus, including (1) characterizing care transition and predicting clinical events and quality of life for patients discharged after an acute coronary syndrome; (2) identifying center and regional factors associated with better patient outcomes across several cardiovascular conditions and procedures; and (3) examining the impact of healthcare reform in Massachusetts on overall and disparate care and outcomes for several cardiovascular conditions and venous thromboembolism. Cross-program collaborations seek to advance the field methodologically and to develop early-stage investigators committed to careers in outcomes research. Conclusions—The Centers for Cardiovascular Outcomes Research program represents a significant investment in cardiovascular outcomes research by the National Heart, Lung, and Blood Institute. The vision of this program is to leverage scientific rigor and cross-program collaboration to advance the science of healthcare delivery and outcomes beyond what any individual unit could achieve alone.

[1]  H. Krumholz.  Real-world imperative of outcomes research. , 2011, JAMA.

[2]  S. Normand,et al.  Patterns of Hospital Performance in Acute Myocardial Infarction and Heart Failure 30-Day Mortality and Readmission , 2009, Circulation. Cardiovascular quality and outcomes.

[3]  H. Krumholz.  Medicine in the era of outcomes measurement. , 2009, Circulation. Cardiovascular quality and outcomes.

[4]  J. Alpert,et al.  A 30-Year Perspective (1975–2005) Into the Changing Landscape of Patients Hospitalized With Initial Acute Myocardial Infarction: Worcester Heart Attack Study , 2009, Circulation. Cardiovascular quality and outcomes.

[5]  M. Fine,et al.  Predictors of early hospital readmission after acute pulmonary embolism. , 2009, Archives of internal medicine.

[6]  R. Auer,et al.  Efficacy of In-Hospital Multidimensional Interventions of Secondary Prevention After Acute Coronary Syndrome: A Systematic Review and Meta-Analysis , 2008, Circulation.

[7]  Mahzarin R. Banaji,et al.  Implicit Bias among Physicians and its Prediction of Thrombolysis Decisions for Black and White Patients , 2007, Journal of General Internal Medicine.

[8]  Judith A. Long,et al.  African American race was associated with an increased risk of complications following venous thromboembolism. , 2007, Journal of clinical epidemiology.

[9]  M. Fine,et al.  Racial differences in 30-day mortality for pulmonary embolism. , 2006, American journal of public health.

[10]  Lisa Hartling,et al.  Meta-Analysis: Secondary Prevention Programs for Patients with Coronary Artery Disease , 2005, Annals of Internal Medicine.

[11]  L. Goldman,et al.  Report of the National Heart, Lung, and Blood Institute Working Group on Outcomes Research in Cardiovascular Disease , 2005, Circulation.

[12]  W. Gibler,et al.  Racial Variations in Treatment and Outcomes of Black and White Patients With High-Risk Non–ST-Elevation Acute Coronary Syndromes: Insights From CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?) , 2005, Circulation.

[13]  Á. Avezum,et al.  A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. , 2004, JAMA.

[14]  W. Gibler,et al.  Insurance status and the treatment of myocardial infarction at academic centers. , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[15]  W. Gibler,et al.  The impact of race on the acute management of chest pain. , 2003, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[16]  D. Mannino,et al.  Pulmonary embolism mortality in the United States, 1979-1998: an analysis using multiple-cause mortality data. , 2003, Archives of internal medicine.

[17]  Sunil V. Rao,et al.  Poverty, process of care, and outcome in acute coronary syndromes. , 2003, Journal of the American College of Cardiology.

[18]  B. Friedman,et al.  Primary Care, HMO Enrollment, and Hospitalization for Ambulatory Care Sensitive Conditions: A New Approach , 2002, Medical care.

[19]  B. Yawn,et al.  Trends in the Incidence and Survival of Patients with Hospitalized Myocardial Infarction, Olmsted County, Minnesota, 1979 to 1994 , 2002, Annals of Internal Medicine.

[20]  D R Jacobs,et al.  Trends in Acute Coronary Heart Disease Mortality, Morbidity, and Medical Care From 1985 Through 1997: The Minnesota Heart Survey , 2001, Circulation.

[21]  Jeroan J Allison,et al.  Relation of race and sex to the use of reperfusion therapy in Medicare beneficiaries with acute myocardial infarction. , 2000, The New England journal of medicine.

[22]  D. Levy,et al.  Prediction of coronary heart disease using risk factor categories. , 1998, Circulation.

[23]  E. Funkhouser,et al.  Disparities by insurance status in quality of care for elderly patients with unstable angina. , 2006, Ethnicity & disease.