Enabling Large Scale Individual-Based Modelling through High Performance Computing

We present a novel large scale parallel computational model allowing 3-D si- mulations of cell colonies growing and interacting with variable environment. The cells are modelled as individual objects located in the lattice-free 3-D space. The model incor- porates cellular environment described in a continuous manner. Discrete and continuous formulations are efficiently coupled in one model allowing considerations of cell colonies composed of up to 10 9 individual cells. This large scale computational approach enables simulations to be carried out over realistic spatial scales up to 1cm 3 in size i.e. the tissue scale.