DETERMINATION OF TRACE XANTHINE BY ANODIC STRIPPING VOLTAMMETRY WITH CARBON NANOTUBE MODIFIED GLASSY CARBON ELECTRODE

ABSTRACT The electrochemistry of xanthine (Xa) was studied by CV at a glassy carbon electrode modified with carbon nanotubes. A well defined, sensitive oxidation wave of xanthine and a small reduction wave were obtained. Based on the oxidation peak, a method for determination of xanthine with semi-derivative anodic stripping voltammetry at a glassy carbon electrode modified with carbon nanotubes was investigated. The stripping peak current is proportional to the concentration of Xa over the range 2.0 × 10−7–2.0 × 10−5 M with 1-min accumulation. The detection limit is 4.0 × 10−9 mol/L with 3-min accumulation. The method has been successfully applied to the determination of xanthine in human serum.

[1]  Richard J. Coles,et al.  Protein electrochemistry at carbon nanotube electrodes , 1997 .

[2]  J. P. Riley,et al.  The determinatin of purines in fresh and sea water by cathodic stripping voltammetry after complexation with copper(I) , 1987 .

[3]  C. Lieber,et al.  Atomic structure and electronic properties of single-walled carbon nanotubes , 1998, Nature.

[4]  Z. Gu,et al.  Investigation of the electrochemical and electrocatalytic behavior of single-wall carbon nanotube film on a glassy carbon electrode. , 2001, Analytical chemistry.

[5]  S. Iijima.  Helical microtubules of graphitic carbon , 1991, Nature.

[6]  K. Méténier,et al.  Supercapacitor electrodes from multiwalled carbon nanotubes , 2000 .

[7]  Pulickel M. Ajayan,et al.  Application of Carbon Nanotubes as Supports in Heterogeneous Catalysis , 1994 .

[8]  Pulickel M. Ajayan,et al.  Carbon nanotube electrode for oxidation of dopamine , 1996 .

[9]  H. Dai,et al.  Individual single-wall carbon nanotubes as quantum wires , 1997, Nature.

[10]  S. Saito.  Carbon Nanotubes for Next-Generation Electronics Devices , 1997, Science.

[11]  D. Bethune,et al.  Storage of hydrogen in single-walled carbon nanotubes , 1997, Nature.

[12]  C. R. Martin,et al.  Carbon nanotubule membranes for electrochemical energy storage and production , 1998, Nature.

[13]  A. Erdem,et al.  Buttermilk Based Cobalt Phthalocyanine Dispersed Ferricyanide Mediated Amperometric Biosensor for the Determination of Xanthine , 1998 .

[14]  Zhennan Gu,et al.  Direct electrochemistry of cytochrome c at a glassy carbon electrode modified with single-wall carbon nanotubes. , 2002, Analytical chemistry.