Limbic activation during cue-induced cocaine craving.

OBJECTIVE Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans. METHOD Using positron emission tomography, the researchers measured relative regional cerebral blood flow (CBF) in limbic and comparison brain regions of 14 detoxified male cocaine users and six cocaine-naive comparison subjects during exposure to both non-drug-related and cocaine-related videos and during resting baseline conditions. RESULTS During the cocaine video, the cocaine users experienced craving and showed a pattern of increases in limbic (amygdala and anterior cingulate) CBF and decreases in basal ganglia CBF relative to their responses to the non-drug video. This pattern did not occur in the cocaine-naive comparison subjects, and the two groups did not differ in their responses in the comparison regions (i.e., the dorsolateral prefrontal cortex, cerebellum, thalamus, and visual cortex). CONCLUSIONS These findings indicate that limbic activation is one component of cue-induced cocaine craving. Limbic activation may be similarly involved in appetitive craving for other drugs and for natural rewards.

[1]  P F Renshaw,et al.  Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. , 1998, The American journal of psychiatry.

[2]  S. Hyman,et al.  Acute Effects of Cocaine on Human Brain Activity and Emotion , 1997, Neuron.

[3]  Karl J. Friston,et al.  Neuroanatomical correlates of externally and internally generated human emotion. , 1997, The American journal of psychiatry.

[4]  D. Roberts,et al.  Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure , 1997, Psychopharmacology.

[5]  Peter Herscovitch,et al.  Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. , 1997, Archives of general psychiatry.

[6]  Robert F. Dannals,et al.  Increased mu opioid receptor binding detected by PET in cocaine–dependent men is associated with cocaine craving , 1996, Nature Medicine.

[7]  D. Perrett,et al.  A differential neural response in the human amygdala to fearful and happy facial expressions , 1996, Nature.

[8]  V L Villemagne,et al.  Activation of memory circuits during cue-elicited cocaine craving. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  G. Koob,et al.  Drug Addiction: The Yin and Yang of Hedonic Homeostasis , 1996, Neuron.

[10]  R. Wise,et al.  The neurobiology of addiction , 2019, Annals of the New York Academy of Sciences.

[11]  E. Nestler,et al.  Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists , 1996, Science.

[12]  K. Delucchi,et al.  Haloperidol antagonism of cue-elicited cocaine craving , 1996, The Lancet.

[13]  L J Porrino,et al.  Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  T. Kosten,et al.  A Review of Pharmacotherapies for Substance Abuse , 1996 .

[15]  R. Gur,et al.  Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water , 1995, Psychiatry Research: Neuroimaging.

[16]  Richard Coppola,et al.  Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study , 1995, Neuropsychologia.

[17]  E. Halgren,et al.  Cortical metabolic activation in humans during a visual memory task. , 1995, Cerebral cortex.

[18]  B. Horwitz,et al.  Brain activity during transient sadness and happiness in healthy women. , 1995, The American journal of psychiatry.

[19]  R. Dolan,et al.  Changes in regional cerebral blood flow on recovery from depression , 1995, Psychological Medicine.

[20]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[21]  Joseph E. LeDoux,et al.  Emotional memory systems in the brain , 1993, Behavioural Brain Research.

[22]  Elliot A. Stein,et al.  Cocaine's time action profile on regional cerebral blood flow in the rat , 1993, Brain Research.

[23]  S. B. Caine,et al.  Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. , 1993, Science.

[24]  N. Volkow,et al.  Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers , 1993, Synapse.

[25]  G F Koob,et al.  Withdrawal following cocaine self‐administration decreases regional cerebral metabolic rate in critical brain reward regions , 1993, Synapse.

[26]  J. Mendelson,et al.  Regional cerebral blood flow improves with treatment in chronic cocaine polydrug users. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[27]  M. Herkenham,et al.  Molecular alterations in the neostriatum of human cocaine addicts , 1993, Synapse.

[28]  G D Pearlson,et al.  Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects. , 1993, The American journal of psychiatry.

[29]  C. Olson,et al.  Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. , 1992, Cerebral cortex.

[30]  H. Fibiger,et al.  Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[31]  R. Ehrman,et al.  Using cue reactivity to screen medications for cocaine abuse: a test of amantadine hydrochloride. , 1992, Addictive behaviors.

[32]  E. Stein,et al.  Selective effects of cocaine on regional cerebral blood flow in the rat. , 1992, The Journal of pharmacology and experimental therapeutics.

[33]  R. Spealman,et al.  Modulation of the discriminative stimulus effects of cocaine by mu and kappa opioids. , 1992, The Journal of pharmacology and experimental therapeutics.

[34]  A. Imperato,et al.  Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction. , 1992, European Journal of Pharmacology.

[35]  F M Miezin,et al.  Activation of the hippocampus in normal humans: a functional anatomical study of memory. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Joseph E. LeDoux,et al.  Emotion and the amygdala. , 1992 .

[37]  B. Hoebel,et al.  CONDITIONED RELEASE OF NEUROTRANSMITTERS AS MEASURED BY MICRODIALYSIS , 1992, Clinical neuropharmacology.

[38]  Karl J. Friston,et al.  Decreases in Regional Cerebral Blood Flow with Normal Aging , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  John Sharkey,et al.  Acute cocaine administation: effects on local cerebral blood flow and metabolic demand in the rat , 1991, Brain Research.

[40]  G F Koob,et al.  Postcocaine anhedonia: An animal model of cocaine withdrawal and its reversal by pharmacological treatments Athina Markou, M.A., Richard L. Hauger, M.D., George F. Koob, Ph.D. Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, CA 92037 , 1991, Biological Psychiatry.

[41]  J S Fowler,et al.  Changes in brain glucose metabolism in cocaine dependence and withdrawal. , 1991, The American journal of psychiatry.

[42]  F. Gawin.  Cocaine addiction: psychology and neurophysiology. , 1991, Science.

[43]  John F. Marshall,et al.  The mesolimbic dopamine system: From motivation to action , 1991 .

[44]  P. Kalivas,et al.  The basal forebrain : anatomy to function , 1991 .

[45]  R. Hammer,et al.  Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. , 1991, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[46]  R. Ehrman,et al.  Responding to drug-related stimuli in humans as a function of drug-use history. , 1991, NIDA research monograph.

[47]  J M Links,et al.  Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose. , 1990, Archives of general psychiatry.

[48]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[49]  P. Kalivas,et al.  Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens , 1990, Synapse.

[50]  T. Robbins,et al.  Interactions between the amygdala and ventral striatum in stimulus-reward associations: Studies using a second-order schedule of sexual reinforcement , 1989, Neuroscience.

[51]  M W Fischman,et al.  The pharmacology of cocaine related to its abuse. , 1989, Pharmacological reviews.

[52]  B. Wallace,et al.  Psychological and environmental determinants of relapse in crack cocaine smokers. , 1989, Journal of substance abuse treatment.

[53]  N. Volkow,et al.  Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography , 1988, British Journal of Psychiatry.

[54]  A. Crane,et al.  Selective alterations in cerebral metabolism within the mesocorticolimbic dopaminergic system produced by acute cocaine administration in rats. , 1988, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[55]  R. Ehrman,et al.  Conditioned craving and arousal in cocaine addiction: a preliminary report. , 1988, NIDA research monograph.

[56]  R. Ehrman,et al.  Classically conditioned responses in opioid and cocaine dependence: a role in relapse? , 1988, NIDA research monograph.

[57]  E. London,et al.  Effects of l-cocaine on local cerebral glucose utilization in the rat , 1986, Neuroscience Letters.

[58]  H. Kleber,et al.  Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations. , 1986, Archives of general psychiatry.

[59]  M. Gold,et al.  New concepts in cocaine addiction: The dopamine depletion hypothesis , 1985, Neuroscience & Biobehavioral Reviews.

[60]  H. Kleber,et al.  Methylphenidate treatment of cocaine abusers without attention deficit disorder: a negative report. , 1985, The American journal of drug and alcohol abuse.

[61]  J. Gray,et al.  The neuropsychology of anxiety. , 1985, Issues in mental health nursing.

[62]  L. Sokoloff,et al.  Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. , 1981, Federation proceedings.

[63]  H. Fibiger,et al.  On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine , 1977, Pharmacology Biochemistry and Behavior.

[64]  P. Maclean.  Psychosomatic Disease and the "Visceral Brain": Recent Developments Bearing on the Papez Theory of Emotion , 1949, Psychosomatic medicine.

[65]  J. W. Papez.  A PROPOSED MECHANISM OF EMOTION , 1937 .