Solution property of hydrophobized pullulan conjugated with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer. Formation of nanoparticles and their thermosensitivity

Poly(ethylene oxide-co-propylene oxide-co-ethylene oxide) (PL) has been successfully bonded to a cholesterol-bearing pullulan through an ester linkage by using a water-soluble carbodiimide. The resulting polymer forms nanoparticles by self-aggregation in water. The PL moieties retain teir thermosensitivity, which was suggested by 1 H NMR and fluorescence spectroscopy