Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.

[1]  A. Fernandes,et al.  Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase. , 2010, Biochemical pharmacology.

[2]  L. Szekely,et al.  High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy. , 2009, Free radical biology & medicine.

[3]  S. Berners‐Price,et al.  1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity. , 2009, Dalton transactions.

[4]  R. Hondal,et al.  No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue. , 2009, Biochemistry.

[5]  Elias S. J. Arnér.  Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions. , 2009, Biochimica et biophysica acta.

[6]  A. Casini,et al.  Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs , 2009 .

[7]  H. Jörnvall,et al.  Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1. , 2009, Free radical biology & medicine.

[8]  Y. Lindqvist,et al.  Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1* , 2009, Journal of Biological Chemistry.

[9]  K. Brown,et al.  The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. , 2008, Biochemical pharmacology.

[10]  S. Berners‐Price,et al.  The Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics , 2008 .

[11]  S. Berners‐Price,et al.  Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols. , 2008, Journal of the American Chemical Society.

[12]  J. Whelan,et al.  Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound. , 2008, Carcinogenesis.

[13]  Elias S. J. Arnér,et al.  Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells , 2008, PloS one.

[14]  P. Leedman,et al.  A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria. , 2007, Biochemical pharmacology.

[15]  K. Fritz-Wolf,et al.  The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis. , 2007, Journal of molecular biology.

[16]  Stephen J Lippard,et al.  Direct cellular responses to platinum-induced DNA damage. , 2007, Chemical reviews.

[17]  C. Borner,et al.  Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. , 2006, Blood.

[18]  V. Gladyshev,et al.  Characterization of Alternative Cytosolic Forms and Cellular Targets of Mouse Mitochondrial Thioredoxin Reductase* , 2006, Journal of Biological Chemistry.

[19]  S. Stone-Elander,et al.  Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C , 2006, Nature Protocols.

[20]  G. Powis,et al.  Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds , 2006, Anti-cancer drugs.

[21]  R. Raines,et al.  Semisynthesis and characterization of mammalian thioredoxin reductase. , 2006, Biochemistry.

[22]  A. Holmgren,et al.  Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase* , 2006, Journal of Biological Chemistry.

[23]  V. Gladyshev,et al.  Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[24]  A. Holmgren,et al.  Thioredoxin Reductase Is Irreversibly Modified by Curcumin , 2005, Journal of Biological Chemistry.

[25]  Gerhard K. H. Przemeck,et al.  Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development , 2005, Molecular and Cellular Biology.

[26]  W. Wurst,et al.  Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function , 2004, Molecular and Cellular Biology.

[27]  Elias S. J. Arnér,et al.  Assessment of Production Conditions for Efficient Use of Escherichia coli in High-Yield Heterologous Recombinant Selenoprotein Synthesis , 2004, Applied and Environmental Microbiology.

[28]  A. Damdimopoulos,et al.  Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition. , 2004, Free radical biology & medicine.

[29]  A. Holmgren,et al.  Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase* , 2004, Journal of Biological Chemistry.

[30]  A. Folda,et al.  Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c. , 2004, Biochemical pharmacology.

[31]  S. Rhee,et al.  Identification and Characterization of TRP14, a Thioredoxin-related Protein of 14 kDa , 2004, Journal of Biological Chemistry.

[32]  K. Becker,et al.  The thioredoxin system—From science to clinic , 2004, Medicinal research reviews.

[33]  F. Lederer,et al.  Interactions of Quinones with Thioredoxin Reductase , 2003, Journal of Biological Chemistry.

[34]  Johan Hansson,et al.  Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling* , 2003, The Journal of Biological Chemistry.

[35]  G. Powis,et al.  The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice , 2003, Molecular and Cellular Biology.

[36]  H. Jäckle,et al.  Mitochondrial and Cytoplasmic Thioredoxin Reductase Variants Encoded by a Single Drosophila Gene Are Both Essential for Viability* , 2002, The Journal of Biological Chemistry.

[37]  Elias S. J. Arnér.  Recombinant expression of mammalian selenocysteine-containing thioredoxin reductase and other selenoproteins in Escherichia coli. , 2002, Methods in enzymology.

[38]  Elias S. J. Arnér,et al.  Measurement of Thioredoxin and Thioredoxin Reductase , 2005, Current protocols in toxicology.

[39]  A. Holmgren,et al.  Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex. , 2001, Free radical biology & medicine.

[40]  G. Schneider,et al.  Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. Stadtman,et al.  Overexpression of wild type and SeCys/Cys mutant of human thioredoxin reductase in E. coli: the role of selenocysteine in the catalytic activity. , 2001, Free radical biology & medicine.

[42]  Elias S. J. Arnér,et al.  Physiological functions of thioredoxin and thioredoxin reductase. , 2000, European journal of biochemistry.

[43]  A. Holmgren,et al.  Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations* , 2000, The Journal of Biological Chemistry.

[44]  Elias S. J. Arnér,et al.  Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[45]  T. Stadtman,et al.  Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[46]  A. Böck,et al.  High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. , 1999, Journal of molecular biology.

[47]  G. Powis,et al.  Cloning, sequencing and functional expression of a novel human thioredoxin reductase , 1999, FEBS letters.

[48]  M. Maines.  Current protocols in toxicology , 1999 .

[49]  R. Schirmer,et al.  Human Placenta Thioredoxin Reductase , 1998, The Journal of Biological Chemistry.

[50]  A. Bindoli,et al.  Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability. , 1998, Free radical biology & medicine.

[51]  Elias S. J. Arnér,et al.  Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. , 1996, Biochemical and biophysical research communications.

[52]  T C Stadtman,et al.  Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[53]  S. Crooke,et al.  Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes. , 1986, Journal of medicinal chemistry.

[54]  A. Holmgren,et al.  Rat liver thioredoxin and thioredoxin reductase: purification and characterization. , 1982, Biochemistry.

[55]  A. Holmgren.  Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction. , 1977, The Journal of biological chemistry.

[56]  L. Reed,et al.  Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase. , 1951, Science.