Dexmedetomidine Ameliorates Renal Ischemia Reperfusion-Mediated Activation of the NLRP3 Inflammasome in Alveolar Macrophages.

[1]  Hailun Li,et al.  miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A , 2020, Aging.

[2]  Yuan Yu,et al.  NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB. , 2020, International immunopharmacology.

[3]  Wenyu Bian,et al.  Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion , 2020, Molecular medicine reports.

[4]  M. Nangaku,et al.  Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury , 2020, Scientific Reports.

[5]  Donghai Liu,et al.  Inhibiting MicroRNA-29a Protects Myocardial Ischemia-Reperfusion Injury by Targeting SIRT1 and Suppressing Oxidative Stress and NLRP3-Mediated Pyroptosis Pathway , 2019, The Journal of Pharmacology and Experimental Therapeutics.

[6]  C. Ronco,et al.  Distant organ dysfunction in acute kidney injury , 2020, Acta physiologica.

[7]  Qingguo Wang,et al.  Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway , 2019, BMC Complementary and Alternative Medicine.

[8]  Lina Lin,et al.  Dexmedetomidine protects against lung injury induced by limb ischemia‐reperfusion via the TLR4/MyD88/NF‐κB pathway , 2019, The Kaohsiung journal of medical sciences.

[9]  L. Gesualdo,et al.  Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury , 2019, Aging.

[10]  Xiaomin Xia,et al.  Polychlorinated Biphenyl Quinone Induces Caspase 1-Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis. , 2019, Chemical research in toxicology.

[11]  Yiwei Zhang,et al.  Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release , 2019, Front. Oncol..

[12]  Xueyuan Bai,et al.  Exogenous biological renal support ameliorates renal pathology after ischemia reperfusion injury in elderly mice , 2019, Aging.

[13]  J. Yang,et al.  Erythropoietin Ameliorates Lung Injury by Accelerating Pulmonary Endothelium Cell Proliferation via Janus Kinase-Signal Transducer and Activator of Transcription 3 Pathway After Kidney Ischemia and Reperfusion Injury. , 2019, Transplantation proceedings.

[14]  Zhongjun Zhang,et al.  Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats , 2019, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[15]  Qiu Chen,et al.  Dexmedetomidine Attenuates Renal and Myocardial Ischemia/Reperfusion Injury in a Dose-Dependent Manner by Inhibiting Inflammatory Response. , 2016, Annals of clinical and laboratory science.

[16]  H. Rabb,et al.  Distant Organ Dysfunction in Acute Kidney Injury: A Review. , 2018, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[17]  R. Xu,et al.  Protective effect of ulinastatin combined with dexmedetomidine on lung injury after cold ischemia-reperfusion in rats. , 2018, European review for medical and pharmacological sciences.

[18]  Lingzhi Yu,et al.  Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR‐381 , 2018, Journal of biochemical and molecular toxicology.

[19]  Y. Choi,et al.  Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats , 2018, bioRxiv.

[20]  Yulin Chang,et al.  Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome , 2018, Inflammation.

[21]  D. Guidot,et al.  Chronic Alcohol Ingestion Impairs Rat Alveolar Macrophage Phagocytosis via Disruption of RAGE Signaling , 2018, The American journal of the medical sciences.

[22]  Azeem Alam,et al.  Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway , 2018, Journal of Translational Medicine.

[23]  Q. Lian,et al.  VEGF mitigates histone‐induced pyroptosis in the remote liver injury associated with renal allograft ischemia–reperfusion injury in rats , 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[24]  J. Schumann,et al.  Polyunsaturated Fatty Acids Induce ROS Synthesis in Microvascular Endothelial Cells. , 2018, Advances in experimental medicine and biology.

[25]  Shitong Li,et al.  Artesunate Inhibits Renal Ischemia Reperfusion-Stimulated Lung Inflammation in Rats by Activating HO-1 Pathway , 2018, Inflammation.

[26]  C. Kallen,et al.  Obesity‐Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury , 2017, American journal of respiratory cell and molecular biology.

[27]  Edward Park,et al.  Alpha-2 Agonists. , 2017, Anesthesiology clinics.

[28]  C. Pfarrer,et al.  Aging exacerbates acute lung injury-induced changes of the air-blood barrier, lung function, and inflammation in the mouse. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[29]  Song Jiao,et al.  NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH , 2017, Journal of Molecular Neuroscience.

[30]  S. Bolkent,et al.  The protective effects of prostaglandin E1 on lung injury following renal ischemia–reperfusion in rats , 2016, Toxicology and industrial health.

[31]  S. Ryter,et al.  NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages , 2016, Nature Medicine.

[32]  Qian Chen,et al.  α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury , 2016, Oncotarget.

[33]  Xin Li,et al.  The effect of insulin-loaded linear poly(ethylene glycol)-brush-like poly(l-lysine) block copolymer on renal ischemia/reperfusion-induced lung injury through downregulating hypoxia-inducible factor , 2016, International journal of nanomedicine.

[34]  H. Rabb,et al.  Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets. , 2016, Kidney international.

[35]  G. Keating.  Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting , 2015, Drugs.

[36]  M. Çakır,et al.  The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats , 2015, Renal failure.

[37]  Li Wang,et al.  Erythropoietin pretreatment ameliorates renal ischaemia‐reperfusion injury by activating PI3K/Akt signalling , 2015, Nephrology.

[38]  Michael Kuncewitch,et al.  Sirtuin 1 Activation Stimulates Mitochondrial Biogenesis and Attenuates Renal Injury After Ischemia-Reperfusion , 2014, Transplantation.

[39]  R. Schnellmann,et al.  Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury. , 2013, Toxicology and applied pharmacology.

[40]  Yulin Chang,et al.  Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated macrophages in vitro. , 2013, The Journal of surgical research.

[41]  M. Nematbakhsh,et al.  Protective Role of Recombinant Human Erythropoietin in Kidney and Lung Injury Following Renal Bilateral Ischemia-Reperfusion in Rat Model , 2013, International journal of preventive medicine.

[42]  E. Altekin,et al.  The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis , 2013, TheScientificWorldJournal.

[43]  N. Câmara,et al.  Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages , 2013, Cellular Physiology and Biochemistry.

[44]  P. Tsai,et al.  Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats. , 2009, Resuscitation.

[45]  E. Bajwa.  The genetics of acute lung injury: looking back and pointing the way forward , 2009, Critical care.

[46]  R. Star,et al.  D-melanocyte Stimulating Hormone Inhibits Lung Injury after Renal Ischemia- Reperfusion , 2022 .

[47]  H. Rabb,et al.  Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. , 1999, Kidney international.

[48]  P. R. Miles,et al.  Constitutive nitric oxide production by rat alveolar macrophages. , 1998, American journal of physiology. Lung cellular and molecular physiology.