A dissertation for the degree of Doctor of Philosophy

·······································································i CONTENTS······································································iii LIST OF FIGURES·························································· vii LIST OF ABBREVIATIONS··············································ix GENERAL INTRODUCTION············································1 Chapter I. Adipose stem cells and cancer······································3 Chapter II. Cancer stem cells and chemoresistance·························7 CHAPTER I·····································································12 Adipose stem cells from visceral and subcutaneous fat depots enhance growth and migration of ovarian cancer cells via activation of IL-6/JAK2/STAT3 pathway Abstract············································································13···········································································13 Introduction·······································································14 Materials and Methods························································· 15 Isolation of CD45/CD31 ASCs··········································16 Culture of ASCs and ovarian cancer cells·······························17

[1]  E McClelland,et al.  A statewide study of academic variables affecting performance of baccalaureate nursing graduates on licensure examination. , 1992, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[2]  John A. Endler.  Geographic Variation, Speciation and Clines. , 1977 .

[3]  M. White,et al.  STRUCTURAL HETEROZYGOSITY IN NATURAL POPULATIONS OF THE GRASSHOPPER TRIMEROTROPIS SPARSA , 1951 .

[4]  R. W. Schleicher,et al.  An international assessment of the gas tubine MHTGR , 1992 .

[5]  M. Kirkpatrick,et al.  Evolution of a Species' Range , 1997, The American Naturalist.

[6]  R. Lumaret,et al.  Effect of geographical discontinuity on genetic variation in Quercus ilex L. (holm oak). Evidence from enzyme polymorphism , 1995, Heredity.

[7]  Kevin J. Gaston,et al.  PATTERNS IN THE GEOGRAPHICAL RANGES OF SPECIES , 1990 .

[8]  P. Brussard,et al.  Geographic Patterns and Environmental Gradients: The Central-Marginal Model in Drosophila Revisited , 1984 .

[9]  Stephen D. Prince,et al.  The geographical distribution of prickly lettuce (Lactuca serriola). II: Characteristics of populations near its distribution limit in Britain , 1985 .

[10]  H. Descimon,et al.  Enzyme polymorphism, wing pattern variability, and geographical isolation in an endangered butterfly species , 1993 .

[11]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[12]  G. M. Clarke,et al.  Diazinon resistance, fluctuating asymmetry and fitness in the Australian sheep blowfly, lucilia cuprina. , 1988, Genetics.

[13]  S. Grzesiek,et al.  Solution NMR of proteins within polyacrylamide gels: Diffusional properties and residual alignment by mechanical stress or embedding of oriented purple membranes , 2000, Journal of biomolecular NMR.

[14]  P. Postma,et al.  Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria. , 1985, Microbiological reviews.

[15]  M E Ostrye,et al.  Predicting NCLEX-PN Performance for Practical Nursing Students , 2001, Nurse educator.

[16]  L. Mueller,et al.  Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions , 1998, Nature Structural Biology.

[17]  B. Riddle,et al.  The molecular phylogeographic bridge between deep and shallow history in continental biotas. , 1996, Trends in ecology & evolution.

[18]  M. Soulé,et al.  Phenetics of Natural Populations. II. Asymmetry and Evolution in a Lizard , 1967, The American Naturalist.

[19]  R. Kadmon,et al.  Floristic variation in Israel: a GIS analysis , 1997 .

[20]  James L. Hamrick,et al.  Influence of quaternary history on the population genetic structure of Douglas-fir (Pseudotsuga menziesii) in the Great Basin , 1993 .

[21]  Charles M. Woolf,et al.  Does homozygosity contribute to the asymmetry of common white leg markings in the Arabian horse , 1993 .

[22]  A. Møller,et al.  Patterns of Fluctuating Asymmetry in Sexual Ornaments of Birds from Marginal and Central Populations , 1995, The American Naturalist.

[23]  M. Rosenzweig,et al.  How are diversity and productivity related , 1993 .

[24]  Bruce A. Johnson,et al.  NMR View: A computer program for the visualization and analysis of NMR data , 1994, Journal of biomolecular NMR.

[25]  George E. Watson,et al.  SYMPATRY IN PALEARCTIC ALECTORIS PARTRIDGES , 1962 .

[26]  Eviatar Nevo,et al.  Genetic parallelism of protein polymorphism in nature: ecological test of the neutral theory of molecular evolution , 1988 .

[27]  K. Free,et al.  Writing multiple-choice test items that promote and measure critical thinking. , 2001, The Journal of nursing education.

[28]  Jorgen B. Thomsen,et al.  Biodiversity Hotspots and Major Tropical Wilderness Areas: Approaches to Setting Conservation Priorities , 1998 .

[29]  P. Smouse,et al.  Multivariate fluctuating asymmetry in Israeli adults. , 1993, Human biology.

[30]  L. Cronbach.  Essentials of psychological testing , 1960 .

[31]  Ilkka Hanski,et al.  The Metapopulation Approach, Its History, Conceptual Domain, and Application to Conservation , 1997 .

[32]  G. Meffe,et al.  SINGLE‐ AND MULTIPLE‐LOCUS GENOTYPES AND LIFE‐HISTORY RESPONSES OF GAMBUSIA HOLBROOKI REARED AT TWO TEMPERATURES , 1994, Evolution; international journal of organic evolution.

[33]  C. Schindler,et al.  Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. , 1994, Science.

[34]  A. Bondeau,et al.  Combining agricultural crop models and satellite observations: from field to regional scales , 1998 .

[35]  Mark L. Taper,et al.  Migration within Metapopulations: The Impact upon Local Population Dynamics , 1997 .

[36]  F. Hall,et al.  Global Crop Forecasting , 1980, Science.

[37]  Michael Lynch,et al.  A Quantitative-Genetic Perspective on Conservation Issues , 1996 .

[38]  N. Barton,et al.  Adaptation, speciation and hybrid zones , 1989, Nature.

[39]  Hugh B Britten,et al.  META‐ANALYSES OF THE ASSOCIATION BETWEEN MULTILOCUS HETEROZYGOSITY AND FITNESS , 1996, Evolution; international journal of organic evolution.

[40]  F. Allendorf,et al.  Superior Developmental Stability of Heterozygotes at Enzyme Loci in Salmonid Fishes , 1984, The American Naturalist.

[41]  J. Lawton,et al.  Range, population abundance and conservation. , 1993, Trends in ecology & evolution.

[42]  I. Cuthill,et al.  Asymmetry and human facial attractiveness: symmetry may not always be beautiful , 1995, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[43]  L. Lin,et al.  A concordance correlation coefficient to evaluate reproducibility. , 1989, Biometrics.

[44]  E D Laue,et al.  Conformational flexibility and folding of synthetic peptides representing an interdomain segment of polypeptide chain in the pyruvate dehydrogenase multienzyme complex of Escherichia coli. , 1989, The Journal of biological chemistry.

[45]  M. Rosenzweig,et al.  Tilman's predicted productivity–diversity relationship shown by desert rodents , 1984, Nature.

[46]  H. R. Wilkinson,et al.  Man and the Natural Environment , 1963 .

[47]  Allyn M. Munger.  See Appendix C. , 1963 .

[48]  Therese A. Markow,et al.  Evolutionary Ecology and Developmental Instability , 1995 .

[49]  Bo W. Svensson,et al.  Changes in occupancy, niche breadth and abundance of three Gyrinus species as their respective range limits are approached , 1992 .

[50]  Luc Lens,et al.  Fluctuating asymmetry increases with habitat disturbance in seven bird species of a fragmented afrotropical forest , 1999, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[51]  J E Alexander,et al.  A five-year study of graduates' performance on NCLEX-RN. , 1997, The Journal of nursing education.

[52]  Merrill A Peterson.  PHENOLOGICAL ISOLATION, GENE FLOW AND DEVELOPMENTAL DIFFERENCES AMONG LOW‐ AND HIGH‐ELEVATION POPULATIONS OF EUPHILOTES ENOPTES (LEPIDOPTERA: LYCAENIDAE) , 1995, Evolution; international journal of organic evolution.

[53]  Heike Bach,et al.  Yield estimation of corn based on multitemporal LANDSAT-TM data as input for an agrometeorological model , 1998 .

[54]  Kevin J. Gaston,et al.  On the Relationship between Range Size and Local Abundance: Back to Basics , 1997 .

[55]  Dolph Schluter,et al.  Species diversity in ecological communities: historical and geographical perspectives. , 1993 .

[56]  J K Waterhouse,et al.  National Council Licensure Examination success: accurate prediction of student performance on the post-1988 examination. , 1993, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[57]  G. M. Clarke,et al.  Developmental Stability and Fitness: The Evidence Is Not Quite So Clear , 1998, The American Naturalist.

[58]  L. Cronbach.  Five perspectives on the validity argument. , 1988 .

[59]  M. du Plessis,et al.  Biodiversity hotspots in the developing world. , 1998, Trends in ecology & evolution.

[60]  Philip U. Alkon,et al.  Genetic Structure of Chukar (Alectoris chukar) Populations in Israel , 1994 .

[61]  Jay Dix.  Identification (I.D.) , 1999 .

[62]  Scott L. Collins,et al.  Importance of Spatial and Temporal Dynamics in Species Regional Abundance and Distribution , 1991 .

[63]  J. Ginsberg,et al.  Global Conservation Priorities , 1999 .

[64]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[65]  E. Kobyliansky,et al.  Fluctuating asymmetry as a possible measure of developmental homeostasis in humans: a review. , 1991, Human biology.

[66]  Berry Pinshow,et al.  Seasonal time-energy budgets of free-living Chukars in the Negev desert , 1987 .

[67]  A. Hoffmann,et al.  Species borders: ecological and evolutionary perspectives. , 1994, Trends in ecology & evolution.

[68]  I Z Siemion,et al.  Conformational preferences of sequential fragments of the hinge region of human IgA1 immunoglobulin molecule: II. , 1989, Biophysical chemistry.

[69]  D. Carl Freeman,et al.  Directional asymmetry and the measurement of developmental instability , 1998 .

[70]  Jian Wang,et al.  A complete sequence of the T. tengcongensis genome. , 2002, Genome research.

[71]  Peter Lesica,et al.  When Are Peripheral Populations Valuable for Conservation , 1995 .

[72]  Min Zhu,et al.  Human adipose tissue is a source of multipotent stem cells. , 2002, Molecular biology of the cell.

[73]  H. Pulliam,et al.  Sources, Sinks, and Population Regulation , 1988, The American Naturalist.

[74]  G. M. Clarke,et al.  The genetic basis of developmental stability. IV. Individual and population asymmetry parameters , 1998, Heredity.

[75]  R. Frankham.  Relationship of genetic variation to population size in wildlife , 1996 .

[76]  John A. Wiens,et al.  The Ecology Of Bird Communities , 1989 .

[77]  W. Rice,et al.  LABORATORY EXPERIMENTS ON SPECIATION: WHAT HAVE WE LEARNED IN 40 YEARS? , 1993, Evolution; international journal of organic evolution.

[78]  Kimberly A. Mcclintock,et al.  Patterns of allozyme variation and clonal diversity in Carex lasiocarpa and C , 1993 .

[79]  J. Goudriaan,et al.  Monitoring rice reflectance at field level for estimating biomass and LAI , 1998 .

[80]  F. Allendorf,et al.  DEVELOPMENTAL INSTABILITY AND HIGH MERISTIC COUNTS IN INTERSPECIFIC HYBRIDS OF SALMONID FISHES , 1985, Evolution; international journal of organic evolution.

[81]  M. Wade,et al.  PERSPECTIVE: THE THEORIES OF FISHER AND WRIGHT IN THE CONTEXT OF METAPOPULATIONS: WHEN NATURE DOES MANY SMALL EXPERIMENTS , 1998, Evolution; international journal of organic evolution.

[82]  Alan F Mark,et al.  A TEST OF THE LOW MARGINAL VARIANCE (LMV) THEORY, IN LEPTOSPERMUM SCOPARIUM (MYRTACEAE) , 1991, Evolution; international journal of organic evolution.

[83]  M S Dell,et al.  Explaining differences in NCLEX-RN scores with certain cognitive and non-cognitive factors for new baccalaureate nurse graduates. , 1990, The Journal of nursing education.

[84]  J K Waterhouse,et al.  Predicting NCLEX-RN performance: cross-validating an identified classification procedure. , 1994, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[85]  P. Cohen,et al.  The regulation of protein function by multisite phosphorylation--a 25 year update. , 2000, Trends in biochemical sciences.

[86]  R Davidhizar,et al.  Strategies to assist students to be successful the next time around on the NCLEX-RN. , 1997, The Journal of nursing education.

[87]  Wilhelm Ludwig,et al.  Das Rechts-Links-Problem im Tierreich und beim Menschen: Mit einem Anhang Rechts-Links-Merkmale der Pflanzen , 1932 .

[88]  Stephan J. Maas,et al.  Remote sensing and crop production models: present trends , 1992 .

[89]  E. Mayr.  Animal Species and Evolution , 1964 .

[90]  E. Tchernov,et al.  The biogeographical history of the southern Levant , 1988 .

[91]  David Tilman,et al.  The maintenance of species richness in plant communities , 1993 .

[92]  Jerard F. Kehoe,et al.  Basic Item Analysis for Multiple-Choice Tests. ERIC/AE Digest. , 1995 .

[93]  Y. Yom-Tov,et al.  Zoogeography of the Diptera of Israel. , 1988 .

[94]  G. Robillard,et al.  Enzymes II of the phosphoenolpyruvate-dependent sugar transport systems: a review of their structure and mechanism of sugar transport. , 1988, Biochimica et biophysica acta.

[95]  Lakshmaiah Sreerama,et al.  Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study , 2002, Cancer Chemotherapy and Pharmacology.

[96]  Jeffrey K. Smith,et al.  The Consequence of Consequence: Motivation, Anxiety, and Test Performance , 1995 .

[97]  David B. Lindenmayer,et al.  A simulation study of the impacts of population subdivision on the mountain brushtail possum Trichosurus caninus Ogilby (Phalangeridae: Marsupialia), in south-eastern Australia. II. Loss of genetic variation within and between subpopulations , 1995 .

[98]  J. Berek,et al.  Ovarian cancer: epidemiology, biology, and prognostic factors. , 2000, Seminars in surgical oncology.

[99]  I. Hanski,et al.  Metapopulation dynamics: Does it help to have more of the same? , 1989, Trends in ecology & evolution.

[100]  John W. Atkinson,et al.  A theory of achievement motivation , 1966 .

[101]  B. Skinner,et al.  Principles of Behavior , 1944 .

[102]  R. Holt.  Population dynamics in two-patch environments: Some anomalous consequences of an optimal habitat distribution , 1985 .

[103]  J. Lawton,et al.  Population abundances, geographic ranges and conservation: 1994 Witherby Lecture , 1996 .

[104]  D Arathuzik,et al.  Factors associated with National Council Licensure Examination-Registered Nurse success. , 1998, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[105]  Andrew D. Taylor,et al.  Empirical Evidence for Metapopulation Dynamics , 1997 .

[106]  C Heupel,et al.  A model for intervention and predicting success on the National Council Licensure Examination for Registered Nurses. , 1994, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[107]  R. Thornhill,et al.  Fluctuating asymmetry and sexual selection. , 1994, Trends in ecology & evolution.

[108]  D. Barford,et al.  The structure and mechanism of protein phosphatases: insights into catalysis and regulation. , 1998, Annual review of biophysics and biomolecular structure.

[109]  J. Connell.  Diversity in tropical rain forests and coral reefs. , 1978, Science.

[110]  Jeffrey K. Smith,et al.  Consequence of Performance, Test, Motivation, and Mentally Taxing Items , 1995 .

[111]  Tim D. Smith,et al.  Principles for the conservation of wild living resources , 1996 .

[112]  Jennifer Bosma,et al.  The NCLEX-RN/Ms. Washburn's & Ms. Short's response , 1992 .

[113]  A. Møller,et al.  Asymmetry, Developmental Stability, and Evolution , 1998 .

[114]  William B. Michael,et al.  Criterion-Related Validity of Selected Achievement Measures in the Prediction of a Passing or Failing Criterion on the National Council Licensure Examination (NCLEX) for Nursing Students in a Two-Year Associate Degree Program , 1995 .

[115]  Salit Kark,et al.  Core and Peripheral-Populations and Global Climate-Change , 1994 .

[116]  Uzi Paz,et al.  The Birds of Israel , 1987 .

[117]  N. Lewis.  A dynamic theory of personality , 1935 .

[118]  Wolfgang Schmidt,et al.  Effects of Human-Caused Disturbances on the Flora along a Mediterranean-Desert Gradient , 1992 .

[119]  C. F. Shaykewich,et al.  A temperature response function for corn development , 1990 .

[120]  A. Mills,et al.  The odds for success on NCLEX-RN by nurse candidates from a four-year baccalaureate nursing program. , 1992, The Journal of nursing education.

[121]  John C. Avise,et al.  Molecular Markers, Natural History, and Evolution , 1993 .

[122]  Pirkko Siikamäki,et al.  FLUCTUATING ASYMMETRY IN CENTRAL AND MARGINAL POPULATIONS OF LYCHNIS VISCARIA IN RELATION TO GENETIC AND ENVIRONMENTAL FACTORS , 1998, Evolution; international journal of organic evolution.

[123]  A. Mills,et al.  Success-failure on the National Council Licensure Examination for Registered Nurses by nurse candidates from an accelerated baccalaureate nursing program. , 1992, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[124]  R. Wayne,et al.  A role for ecotones in generating rainforest biodiversity , 1997 .

[125]  S. Grzesiek,et al.  NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.

[126]  Philip U. Alkon,et al.  Water Intake, Existence Energy, and Responses to Water Deprivation in the Sand Patridge Ammoperdix heyi and the Chukar Alectoris chukar: Two Phasianids of the Negev Desert , 1983, Physiological Zoology.

[127]  M. Taper,et al.  Environmental Variation and the Persistence of Small Populations. , 1992, Ecological applications : a publication of the Ecological Society of America.

[128]  M. Yeadon,et al.  1H-NMR study of mobility and conformational constraints within the proline-rich N-terminal of the LC1 alkali light chain of skeletal myosin. Correlation with similar segments in other protein systems. , 1986, European journal of biochemistry.

[129]  Scott E. Maxwell,et al.  Designing Experiments and Analyzing Data: A Model Comparison Perspective , 1990 .

[130]  Dawn M. Kaufman,et al.  THE GEOGRAPHIC RANGE: Size, Shape, Boundaries, and Internal Structure , 1996 .

[131]  D Billings,et al.  Computerized NCLEX-RN preparation programs. A comparative review. , 1996, Computers in nursing.

[132]  A. Møller,et al.  Sexual ornament size and the cost of fluctuating asymmetry , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[133]  James Mallet,et al.  Genetic Analysis of Founder Bottlenecks in the Rare British Butterfly Plebejus argus , 1997 .

[134]  M G Anema,et al.  The relationship of academic variables as predictors of success on the National Council Licensure Examination for Registered Nurses (NCLEX-RN) in a selected associate degree program. , 1999, The ABNF journal : official journal of the Association of Black Nursing Faculty in Higher Education, Inc.

[135]  M. Soulé,et al.  Allomeric Variation. 2. Developmental Instability of Extreme Phenotypes , 1982, The American Naturalist.

[136]  Innes C. Cuthill,et al.  Preference for symmetric males by female zebra finches , 1994, Nature.

[137]  R Keller,et al.  Academic predictors of success on the NCLEX-RN examination for associate degree nursing students. , 1990, The Journal of nursing education.

[138]  John H. Lawton,et al.  Animal distributions : patterns and processes , 1994 .

[139]  D. A. Christie,et al.  The birds of Israel , 1996 .

[140]  C. Hutchinson,et al.  Uses of satellite data for famine early warning in sub-Saharan Africa , 1991 .

[141]  M. Miller,et al.  Measurement and Assessment in Teaching , 1994 .

[142]  H. Westerhoff,et al.  Understanding Glucose Transport by the Bacterial Phosphoenolpyruvate:Glycose Phosphotransferase System on the Basis of Kinetic Measurements in Vitro * , 2000, The Journal of Biological Chemistry.

[143]  James H. Brown.  On the Relationship between Abundance and Distribution of Species , 1984, The American Naturalist.

[144]  T. Smith,et al.  Disruptive selection and the genetic basis of bill size polymorphism in the African finch Pyrenestes , 1993, Nature.

[145]  Guangshun Wang,et al.  Solution Structure of the Phosphoryl Transfer Complex between the Cytoplasmic A Domain of the Mannitol Transporter IIMannitol and HPr of the Escherichia coliPhosphotransferase System* , 2002, The Journal of Biological Chemistry.

[146]  W Keck,et al.  Cytoplasmic phosphorylating domain of the mannitol-specific transport protein of the phosphoenolpyruvate-dependent phosphotransferase system in Escherichia coli: overexpression, purification, and functional complementation with the mannitol binding domain. , 1991, Biochemistry.

[147]  P. David,et al.  Measurement bias and fluctuating asymmetry estimates , 1999, Animal Behaviour.

[148]  Geoffrey M. Clarke,et al.  Relationships Between Developmental Stability and Fitness: Application for Conservation Biology , 1995 .

[149]  A. Hoffmann,et al.  Evolutionary Genetics and Environmental Stress , 1991 .

[150]  Peter J. Gregory,et al.  Effects of Temperature, Soil Water Status and Depth of Planting on Germination and Emergence of Maize (Zea Mays) Adapted to Semi-Arid Eastern Kenya , 1993, Experimental Agriculture.

[151]  S. Roseman,et al.  The bacterial phosphoenolpyruvate: glycose phosphotransferase system. , 1990, Annual review of biochemistry.

[152]  Stephen D. Sarre,et al.  The Application of Fluctuating Asymmetry in the Monitoring of Animal Populations , 1994 .

[153]  C. Bandi,et al.  Polymorphism within and between populations of Ceratitis capitata: comparison between RAPD and multilocus enzyme electrophoresis data , 1995, Heredity.

[154]  David A. Frisbie,et al.  Reliability of Scores From Teacher‐Made Tests , 1988 .

[155]  S. Boorman,et al.  Group selection on the boundary of a stable population. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[156]  G Tononi,et al.  Differences in gene expression during sleep and wakefulness. , 1999, Annals of medicine.

[157]  Kathy M. Shumaker,et al.  PATTERNS OF ALLOZYMIC SIMILARITY IN ECOLOGICALLY CENTRAL AND MARGINAL POPULATIONS OF HORDEUM JUBATUM IN UTAH , 1980, Evolution; international journal of organic evolution.

[158]  K. Gaston,et al.  Biodiversity: An Introduction , 1998 .

[159]  C. Perrins,et al.  Birds of the Western Palearctic , 1978, Nature.

[160]  B. Babior.  NADPH oxidase: an update. , 1999, Blood.

[161]  A. Hoffmann,et al.  THE GENETICS OF CENTRAL AND MARGINAL POPULATIONS OF DROSOPHILA SERRATA. I. GENETIC VARIATION FOR STRESS RESISTANCE AND SPECIES BORDERS , 1993, Evolution; international journal of organic evolution.

[162]  K. Yoo,et al.  Postmenopausal obesity as a breast cancer risk factor according to estrogen and progesterone receptor status (Japan). , 2001, Cancer letters.

[163]  A. Møller,et al.  Female swallow preference for symmetrical male sexual ornaments , 1992, Nature.

[164]  M. Orr,et al.  Ecology and speciation. , 1998, Trends in ecology & evolution.

[165]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[166]  T. Mitchell-Olds,et al.  Does environmental variation maintain genetic variation? A question of scale. , 1992, Trends in ecology & evolution.

[167]  B. Bouman,et al.  Crop modelling and remote sensing for yield prediction , 1995 .

[168]  F. Allendorf,et al.  The One‐Migrant‐per‐Generation Rule in Conservation and Management , 1996 .

[169]  Rob Hengeveld,et al.  The distribution of abundance. I. Measurements , 1982 .

[170]  Niles Eldredge.  Reinventing Darwin: The Great Evolution Debate , 1995 .

[171]  R. Lewontin.  The Genetic Basis of Evolutionary Change , 1974 .

[172]  K. H. Kalk,et al.  The structure of the Escherichia coli phosphotransferase IIAmannitol reveals a novel fold with two conformations of the active site. , 1998, Structure.

[173]  D. G. Walker,et al.  The role of glucokinase in the phosphorylation of glucose by rat liver. , 1964, The Biochemical journal.

[174]  T W Barkley,et al.  Predictors of success on the NCLEX-RN. Among baccalaureate nursing students. , 1998, Nursing and health care perspectives.

[175]  Reinhard Bürger,et al.  The Maintenance of Genetic Variation: A Functional Analytic Approach to Quantitative Genetic Models , 1988 .

[176]  R. Vrijenhoek,et al.  Conservation Genetics of Endangered Fish Populations in Arizona , 1985, Science.

[177]  R. N. Carter,et al.  Epidemic models used to explain biogeographical distribution limits , 1981, Nature.

[178]  Jack J. Lennon,et al.  A metapopulation model of species boundaries , 1997 .

[179]  W. A. Russell,et al.  Stability Parameters for Comparing Varieties , 1966 .

[180]  D. Olson,et al.  The Global 200: A Representation Approach to Conserving the Earth’s Most Biologically Valuable Ecoregions , 1998 .

[181]  G. M. Clarke,et al.  THE GENETIC BASIS OF DEVELOPMENTAL STABILITY. III. HAPLO‐DIPLOIDY: ARE MALES MORE UNSTABLE THAN FEMALES? , 1997, Evolution; international journal of organic evolution.

[182]  J. L. Gittleman,et al.  The Future of Biodiversity , 1995, Science.

[183]  D. Tilman.  Resource competition and community structure. , 1983, Monographs in population biology.

[184]  E. Nevo.  Genetic Diversity in Nature , 1988 .

[185]  Graeme Caughley,et al.  THE EDGE OF THE RANGE , 1988 .

[186]  A. Gronenborn,et al.  Measurement of Residual Dipolar Couplings of Macromolecules Aligned in the Nematic Phase of a Colloidal Suspension of Rod-Shaped Viruses , 1998 .

[187]  M. Gilpin,et al.  Metapopulation Biology: Ecology, Genetics, and Evolution , 1997 .

[188]  O. Warburg.  On the origin of cancer cells. , 1956, Science.

[189]  E Julian,et al.  Moving a National Licensure Examination to Computer , 2001, Nurse educator.

[190]  B. Weiner.  An attributional theory of motivation and emotion , 1986 .

[191]  R. Lande.  Genetics and demography in biological conservation. , 1988, Science.

[192]  P. Gallagher,et al.  Using an Admissions Exam to Predict Student Success in an ADN Program , 2001, Nurse educator.

[193]  C. Jordan.  Derivation of leaf-area index from quality of light on the forest floor , 1969 .

[194]  Naoki Tani,et al.  Genetic diversity and differentiation in populations of Japanese stone pine (Pinus pumila) in Japan , 1996 .

[195]  Thelma A. Percoco.  Variables predictive of program and NCLEX success for associate degree nursing students , 2001 .

[196]  G. Hartl,et al.  Allozyme Heterozygosity and Fluctuating Asymmetry in the Brown Hare (Lepus europaeus): A Test of the Developmental Homeostasis Hypothesis , 1995 .

[197]  A. Palmer.  Fluctuating asymmetry analyses: a primer , 1994 .

[198]  R L Pressey,et al.  Beyond opportunism: Key principles for systematic reserve selection. , 1993, Trends in ecology & evolution.

[199]  Philip U. Alkon,et al.  Conservation Priorities for Chukar Partridge in Israel Based on Genetic Diversity across an Ecological Gradient , 1999 .

[200]  P. Pintrich,et al.  Motivational and self-regulated learning components of classroom academic performance. , 1990 .

[201]  P. Kat,et al.  The Relationship between Heterozygosity for Enzyme Loci and Developmental Homeostasis in Peripheral Populations of Aquatic Bivalves (Unionidae) , 1982, The American Naturalist.

[202]  R. Thornhill,et al.  The evolution of human sexuality. , 1996, Trends in ecology & evolution.

[203]  Luc Lens,et al.  Evidence for organism-wide asymmetry in five bird species of a fragmented afrotropical forest , 1999, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[204]  Amber E. Budden,et al.  Plumage condition affects flight performance in common starlings: implications for developmental homeostasis, abrasion and moult , 1996 .

[205]  H. Carson,et al.  Genetic conditions which promote or retard the formation of species. , 1959, Cold Spring Harbor symposia on quantitative biology.

[206]  J. Boyer,et al.  Relationship of water potential to growth of leaves. , 1968, Plant physiology.

[207]  S G Poorman,et al.  The role of nonacademic variables in passing the National Council Licensure Examination. , 1991, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[208]  K. Mather.  Genetical control of stability in development , 1953, Heredity.

[209]  John C. Avise,et al.  Molecular Markers, Natural History and Evolution , 1993, Springer US.

[210]  B M Wall,et al.  Predictors of Success on the Newest NCLEX-RN , 1993, Western journal of nursing research.

[211]  Robert Powers,et al.  A common sense approach to peak picking in two-, three-, and four-dimensional spectra using automatic computer analysis of contour diagrams , 1991 .

[212]  Philip U. Alkon,et al.  Water Flux in Chukar Partridges (Alectoris chukar) and a Comparison with Other Birds , 1982, Physiological Zoology.

[213]  J. Lengeler,et al.  Enzymes II of the phospho enol pyruvate-dependent phosphotransferase systems: their structure and function in carbohydrate transport. , 1994, Biochimica et biophysica acta.

[214]  J. A. Schell,et al.  Monitoring vegetation systems in the great plains with ERTS , 1973 .

[215]  Harri Vainio,et al.  Overweight, obesity, and cancer risk. , 2002, The Lancet. Oncology.

[216]  S. Deyoung,et al.  Predicting success on the National Council Licensure Examination-Registered Nurse: another piece of the puzzle. , 1991, Journal of professional nursing : official journal of the American Association of Colleges of Nursing.

[217]  K Botzenhart,et al.  Reactive Oxygen Species , 2014 .

[218]  John A. Nelder,et al.  A Simplex Method for Function Minimization , 1965, Comput. J..

[219]  J. Hall,et al.  Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase. , 1990, The Biochemical journal.

[220]  J. H. Graham,et al.  Effects of lead and benzene on the developmental stability of Drosophila melanogaster , 1993, Ecotoxicology.

[221]  P. Parsons,et al.  Environmental Stresses and Conservation of Natural Populations , 1989 .

[222]  N. Myers,et al.  The biodiversity challenge: Expanded hot-spots analysis , 1990, The Environmentalist.

[223]  P. Vellinga,et al.  Climate Change and Extreme Weather Events , 2000 .

[224]  Carlos Viijlar‐Palasí,et al.  The role of glucose 6‐phosphate in the control of glycogen synthase , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[225]  A. J. Noordwijk.  Futuyma, D. J. 1986. Evolutionary Biology 2nd edition, Sinauer Associates Inc. Sunderland, Mass. , 1988 .

[226]  Dennis D. Murphy,et al.  Distribution of the Bay Checkerspot Butterfly, Euphydryas editha bayensis: Evidence for a Metapopulation Model , 1988, The American Naturalist.

[227]  B. Pinshow,et al.  Must Desert Chukars (Alectoris chukar sinaica) Drink Water? Water Influx and Body Mass Changes in Response to Dietary Water Content , 1984 .

[228]  P. A. PARSONS.  Stress and evolution , 1991, Nature.

[229]  T. Dobzhansky,et al.  A FURTHER STUDY OF CHROMOSOMAL POLYMORPHISM IN DROSOPHILA WILLISTONI IN ITS RELATION TO THE ENVIRONMENT , 1954 .

[230]  G. C. Stevens,et al.  Spatial Variation in Abundance , 1995 .

[231]  A. Bax,et al.  Dipolar couplings in macromolecular structure determination. , 2001, Methods in enzymology.

[232]  Linda O. Mearns,et al.  Investigating the Effect of Seasonal Plant Growth and Development in Three-Dimensional Atmospheric Simulations. Part I: Simulation of Surface Fluxes over the Growing Season , 2001 .

[233]  Rob Channell,et al.  Splendid Isolation: Patterns of Geographic Range Collapse in Endangered Mammals , 1995 .

[234]  Randy Thornhill,et al.  Human female orgasm and mate fluctuating asymmetry , 1995, Animal Behaviour.

[235]  M. Arnold.  Natural Hybridization and Evolution , 1997 .

[236]  R L Mayden,et al.  Phylogeny and biodiversity: Conserving our evolutionary legacy. , 1992, Trends in ecology & evolution.

[237]  Geoffrey M. Clarke,et al.  The genetic basis of developmental stability. I: Relationships between stability, heterozygosity and genomic coadaptation , 1993 .

[238]  Eviatar Nevo,et al.  Genetic diversity in the desert: patterns and testable hypotheses , 1989 .

[239]  C. Rosenzweig,et al.  Climate Change and Extreme Weather Events; Implications for Food Production, Plant Diseases, and Pests , 2001 .

[240]  Scott A. Olsen,et al.  A Follow-Up of Suspect Sophomore Scores on the COMP Test. , 1991 .

[241]  Gottfried Otting,et al.  Alignment of Biological Macromolecules in Novel Nonionic Liquid Crystalline Media for NMR Experiments , 2000 .

[242]  I. Cuthill,et al.  The analysis of fluctuating asymmetry , 1994, Animal Behaviour.

[243]  Munich,et al.  A guide to the measurement of animal bones from archaeological sites , 1976 .

[244]  R. A. Fisher,et al.  The Genetical Theory of Natural Selection , 1931 .

[245]  Kevin J. Gaston,et al.  Effects of scale and habitat on the relationship between regional distribution and local abundance , 1990 .

[246]  C. Strobeck,et al.  Fluctuating Asymmetry: Measurement, Analysis, Patterns , 1986 .

[247]  P. Messmer,et al.  Code 50: an orientation matrix to track orientation cost. , 1995, Journal of nursing staff development : JNSD.

[248]  T. C. Hsiao,et al.  Interactive water and nitrogen effects on senescence of maize. I: Leaf area duration, nitrogen distribution, and yield , 1988 .

[249]  H. G. Andrewartha,et al.  The distribution and abundance of animals. , 1954 .

[250]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.