Prophylactic platelet transfusion and risk of bleeding associated with ultrasound‐guided central venous access in patients with severe thrombocytopenia

Reported risk of bleeding complications after central catheter access in patients with thrombocytopenia is highly variable. Current guidelines recommend routine prophylactic platelet (PLT) transfusion before central venous catheter placement in patients with severe thrombocytopenia. Nevertheless, the strength of such recommendations is weak and supported by observational studies including few patients with very low PLT counts (<20 × 109/L). This study aims to assess the risk of bleeding complications related to using or not using prophylactic PLT transfusion before ultrasound‐guided central venous access in patients with very low PLT counts.

[1]  Kaeli J. Yamashiro,et al.  Association of Thrombocytopenia With Bleeding Risk During Central Venous Catheter Placement in Pediatric Patients With Cancer. , 2021, JAMA surgery.

[2]  James R Carpenter,et al.  Sensitivity analysis for clinical trials with missing continuous outcome data using controlled multiple imputation: A practical guide , 2020, Statistics in medicine.

[3]  B. Biemond,et al.  Bleeding assessment and bleeding severity in thrombocytopenic patients undergoing invasive procedures , 2020, Transfusion.

[4]  Paul Madley-Dowd,et al.  The proportion of missing data should not be used to guide decisions on multiple imputation , 2019, Journal of clinical epidemiology.

[5]  G. Pisimisis,et al.  Risk of bleeding after ultrasound-guided jugular central venous catheter insertion in severely thrombocytopenic oncologic patients. , 2019, American journal of surgery.

[6]  P. Rebulla,et al.  Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  E. Balman,et al.  National Institute for Health and Care Excellence (NICE) , 2017, The Grants Register 2022.

[8]  J. Binnekade,et al.  Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications , 2017, Transfusion.

[9]  Katherine J. Lee,et al.  Multiple imputation in the presence of non‐normal data , 2017, Statistics in medicine.

[10]  Zhongheng Zhang,et al.  Multiple imputation with multivariate imputation by chained equation (MICE) package. , 2016, Annals of translational medicine.

[11]  Paul T. von Hippel,et al.  How Many Imputations Do You Need? A Two-stage Calculation Using a Quadratic Rule , 2016, Sociological methods & research.

[12]  P. Marik,et al.  Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients—Part I: General Ultrasonography , 2015, Critical care medicine.

[13]  Benjamin Djulbegovic,et al.  Platelet Transfusion: A Clinical Practice Guideline From the AABB , 2015, Annals of Internal Medicine.

[14]  Amy P Abernethy,et al.  Development of the National Cancer Institute's patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE). , 2014, Journal of the National Cancer Institute.

[15]  Uli K. Chettipally,et al.  Bleeding complications of central venous catheterization in septic patients with abnormal hemostasis. , 2014, The American journal of emergency medicine.

[16]  H. Masuzaki,et al.  Real-time ultrasound-guided central venous catheterization reduces the need for prophylactic platelet transfusion in thrombocytopenic patients with hematological malignancy. , 2013, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[17]  N. Juffermans,et al.  Transfusion-related acute lung injury: a clinical review , 2013, The Lancet.

[18]  Sallie J. Weaver,et al.  Making health care safer II: an updated critical analysis of the evidence for patient safety practices. , 2013, Evidence report/technology assessment.

[19]  Jian Wang,et al.  Real-time Two-dimensional Ultrasound Guidance for Central Venous Cannulation: A Meta-analysis , 2013, Anesthesiology.

[20]  M. Napolitano,et al.  Ultrasonography-guided central venous catheterisation in haematological patients with severe thrombocytopenia. , 2013, Blood transfusion = Trasfusione del sangue.

[21]  D. Feller-Kopman,et al.  International evidence-based recommendations on ultrasound-guided vascular access , 2012, Intensive Care Medicine.

[22]  Lee A Fleisher,et al.  Practice Guidelines for Central Venous Access: A Report by the American Society of Anesthesiologists Task Force on Central Venous Access , 2012, Anesthesiology.

[23]  O. Senn,et al.  Optimal preprocedural platelet transfusion threshold for central venous catheter insertions in patients with thrombocytopenia , 2011, Transfusion.

[24]  Patrick Royston,et al.  Multiple imputation using chained equations: Issues and guidance for practice , 2011, Statistics in medicine.

[25]  S. Trerotola,et al.  Large-bore tunneled central venous catheter insertion in patients with coagulopathy. , 2010, Journal of vascular and interventional radiology : JVIR.

[26]  F. Orsi,et al.  Coagulation disorders in patients with cancer: nontunneled central venous catheter placement with US guidance--a single-institution retrospective analysis. , 2009, Radiology.

[27]  Donald L. Miller,et al.  Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. , 2009, Journal of vascular and interventional radiology : JVIR.

[28]  M. Kenward,et al.  Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls , 2009, BMJ : British Medical Journal.

[29]  J. Encke,et al.  Low Levels of Prothrombin Time (INR) and Platelets Do Not Increase the Risk of Significant Bleeding when Placing Central Venous Catheters* , 2009, Medizinische Klinik.

[30]  V. Kiefel.  Reactions Induced by Platelet Transfusions , 2008, Transfusion Medicine and Hemotherapy.

[31]  L. Oğuzkurt,et al.  US-guided placement of central vein catheters in patients with disorders of hemostasis. , 2008, European journal of radiology.

[32]  S. Pocock,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. , 2007, Preventive medicine.

[33]  Theo Stijnen,et al.  Using the outcome for imputation of missing predictor values was preferred. , 2006, Journal of clinical epidemiology.

[34]  Jeffrey S. Berger,et al.  Mechanical Complications of Central Venous Catheters , 2006, Journal of intensive care medicine.

[35]  J. Segal,et al.  Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence‐based review , 2005, Transfusion.

[36]  B. Konkle.  Percutaneous interventions in the coagulopathic patient. , 2005, Seminars in interventional radiology.

[37]  Daniel Hind,et al.  Ultrasonic locating devices for central venous cannulation: meta-analysis , 2003, BMJ : British Medical Journal.

[38]  J. Schafer,et al.  A comparison of inclusive and restrictive strategies in modern missing data procedures. , 2001, Psychological methods.

[39]  F Golliot,et al.  Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. , 2001, JAMA.

[40]  C. Ray,et al.  Patients with thrombocytopenia: outcome of radiologic placement of central venous access devices. , 1997, Radiology.

[41]  R. Barrera,et al.  Acute complications of central line placement in profoundly thrombocytopenic cancer patients , 1996, Cancer.

[42]  T. Deloughery,et al.  Invasive line placement in critically ill patients: do hemostatic defects matter? , 1996, Transfusion.

[43]  M. Doerfler,et al.  Central venous catheter placement in patients with disorders of hemostasis. , 1996, Chest.

[44]  Haim Bitterman,et al.  Central vein catheterization. Failure and complication rates by three percutaneous approaches. , 1986, Archives of internal medicine.

[45]  E. Morse.  Platelet transfusions. , 1971, British medical journal.