Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis

[1]  Jiandie D. Lin,et al.  hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis , 2020, Hepatology.

[2]  Ligeng Xu,et al.  Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy , 2019, Nature Communications.

[3]  Leaf Huang,et al.  Nanomaterial Manipulation of Immune Microenvironment in the Diseased Liver , 2018, Advanced Functional Materials.

[4]  Ligeng Xu,et al.  Nanoparticle‐mediated HMGA1 Silencing Promotes Lymphocyte Infiltration and Boosts Checkpoint Blockade Immunotherapy for Cancer , 2018, Advanced Functional Materials.

[5]  Melanie H. Wong,et al.  ASK1 contributes to fibrosis and dysfunction in models of kidney disease , 2018, The Journal of clinical investigation.

[6]  Feng Li,et al.  The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis , 2017, Nature Medicine.

[7]  Igor Jurisica,et al.  mirDIP 4.1—integrative database of human microRNA target predictions , 2017, Nucleic Acids Res..

[8]  N. Ferreirós,et al.  CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages. , 2017, Prostaglandins & other lipid mediators.

[9]  K. Dou,et al.  Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. , 2017, Journal of hepatology.

[10]  M. Gorospe,et al.  RNA in extracellular vesicles , 2017, Wiley interdisciplinary reviews. RNA.

[11]  I. Amit,et al.  Genomic Characterization of Murine Monocytes Reveals C/EBP&bgr; Transcription Factor Dependence of Ly6C− Cells , 2017, Immunity.

[12]  F. Tacke,et al.  Liver macrophages in tissue homeostasis and disease , 2017, Nature Reviews Immunology.

[13]  S. Friedman,et al.  Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis , 2016, PloS one.

[14]  G. von Heijne,et al.  Tissue-based map of the human proteome , 2015, Science.

[15]  D. Metzger,et al.  Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis , 2015, Nature Medicine.

[16]  Sudhir Singh,et al.  Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)* , 2014, The Journal of Biological Chemistry.

[17]  Bin Gao,et al.  Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice , 2014, Journal of leukocyte biology.

[18]  Xiuping Liu,et al.  Regulation of the Extrinsic Apoptotic Pathway by MicroRNA-21 in Alcoholic Liver Injury* , 2014, The Journal of Biological Chemistry.

[19]  Frank Tacke,et al.  Macrophage heterogeneity in liver injury and fibrosis. , 2014, Journal of hepatology.

[20]  J. Fallowfield,et al.  Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo , 2014, Hepatology.

[21]  J. Fallowfield,et al.  Liver fibrosis and repair: immune regulation of wound healing in a solid organ , 2014, Nature Reviews Immunology.

[22]  S. Safe,et al.  Investigation of macrophage polarization using bone marrow derived macrophages. , 2013, Journal of visualized experiments : JoVE.

[23]  C. Tanaka,et al.  An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis , 2013, International journal of experimental pathology.

[24]  Piotr Ponikowski,et al.  Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial , 2013, The Lancet.

[25]  S. Curbishley,et al.  Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics , 2013, Hepatology.

[26]  J. Fallowfield,et al.  Edinburgh Research Explorer Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis Differential Ly-6C expression identi fi es the recruited macrophage phenotype, which orchestrates the regression of murine liver fi brosis , 2022 .

[27]  R. Schwabe,et al.  Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. , 2012, Gastroenterology.

[28]  F. Geissmann,et al.  The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes , 2011, Nature Immunology.

[29]  Y. Sakurai,et al.  Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice , 2011, Nephrology.

[30]  M. Whitfield,et al.  PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis , 2010, PloS one.

[31]  C. Trautwein,et al.  Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. , 2010, The Journal of clinical investigation.

[32]  K. Shimoke,et al.  Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells. , 2010, Journal of biochemistry.

[33]  T. Luedde,et al.  Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis , 2010, PloS one.

[34]  Sudhir Singh,et al.  Relaxin signaling activates peroxisome proliferator-activated receptor gamma , 2010, Molecular and Cellular Endocrinology.

[35]  Graça Raposo,et al.  Exosomes--vesicular carriers for intercellular communication. , 2009, Current opinion in cell biology.

[36]  L. Rénia,et al.  Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. , 2009, The American journal of pathology.

[37]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[38]  Xiaoqing Tang,et al.  An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[39]  J. Prieto,et al.  The Role of Thrombopoietin in the Thrombocytopenia of Patients with Liver Cirrhosis , 2005, The American Journal of Gastroenterology.

[40]  Pradeep Tyagi,et al.  Anisamide‐targeted stealth liposomes: A potent carrier for targeting doxorubicin to human prostate cancer cells , 2004, International journal of cancer.

[41]  O. Mariani,et al.  ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14–q15 and 6q23 amplifications , 2004, Genes, chromosomes & cancer.

[42]  R. Rippe,et al.  PPAR Gamma and Hepatic Stellate Cells , 2004, Comparative hepatology.

[43]  V. Brancaccio,et al.  Coagulation disorders in liver disease. , 2002, Seminars in liver disease.

[44]  A. Hsueh,et al.  Activation of Orphan Receptors by the Hormone Relaxin , 2002, Science.

[45]  E. Masini,et al.  Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[46]  C. Peterson,et al.  The Pharmacokinetics of Recombinant Human Relaxin in Nonpregnant Women After Intravenous, Intravaginal, and Intracervical Administration , 1993, Pharmaceutical Research.

[47]  A. Katsarou,et al.  Reporting for specific materials, systems and methods , 2018 .

[48]  G. Lamberti,et al.  Institutional Animal Care and Use Committee , 2017 .

[49]  S. Friedman Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. , 2008, Physiological reviews.

[50]  C. Goresky,et al.  Kupffer cell depletion associated with capillarization of liver sinusoids in carbon tetrachloride-induced rat liver cirrhosis. , 1987, Journal of hepatology.