Gamma-Aminobutyric Acid Antagonism and Presynaptic Inhibition in the Frog Spinal Cord

The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition.

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