Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer

Aim. To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies. Patients and Methods. Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time imaging control in supine position. Results. Adenocarcinoma of the prostate was detected in 39 of 96 patients. For individual core biopsies, MRI yielded a sensitivity of 93.0% and a specificity of 94.4%. When stratifying patients according to the free-to-total prostate-specific antigen (PSA) ratio, the prostate cancer discovery rate was significantly higher in the group with ratios less than 0.15 (57.1%). Conclusion. MRI-guided biopsy of the prostate is a diagnostic option for patients with suspected prostate cancer and a history of repeatedly negative transrectal ultrasound-guided biopsies. Combined with the free-to-total PSA ratio, it is a highly effective method for detecting prostate cancer.

[1]  Ferdinand Frauscher,et al.  Directed biopsy during contrast-enhanced sonography of the prostate. , 2002, AJR. American journal of roentgenology.

[2]  B. Barbiroli,et al.  Accuracy of MRI/MRSI‐based transrectal ultrasound biopsy in peripheral and transition zones of the prostate gland in patients with prior negative biopsy , 2010, NMR in biomedicine.

[3]  Namkug Kim,et al.  Functional MR imaging of prostate cancer. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[4]  William J Catalona,et al.  Serial biopsy results in prostate cancer screening study. , 2002, The Journal of urology.

[5]  Michel Bolla,et al.  [EAU guidelines on prostate cancer]. , 2009, Actas urologicas espanolas.

[6]  A. Zisman,et al.  Saturation prostate biopsy in high risk patients after multiple previous negative biopsies. , 2008, Urology.

[7]  B. Kiefer,et al.  Prostate biopsy in the supine position in a standard 1.5-T scanner under real time MR-imaging control using a MR-compatible endorectal biopsy device , 2006, European Radiology.

[8]  M. Roobol,et al.  Complication rates and risk factors of 5802 transrectal ultrasound-guided sextant biopsies of the prostate within a population-based screening program. , 2002, Urology.

[9]  R. Porcher,et al.  Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate. , 2003, Urology.

[10]  B. Matlaga,et al.  Results of the 5 region prostate biopsy method: the repeat biopsy population. , 2002, The Journal of urology.

[11]  Susanne Hempel,et al.  Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review. , 2006, The Journal of urology.

[12]  Heinz-Peter Schlemmer,et al.  MRI-guided biopsy of the prostate increases diagnostic performance in men with elevated or increasing PSA levels after previous negative TRUS biopsies. , 2006, European urology.

[13]  A. D'Amico,et al.  Transperineal magnetic resonance image guided prostate biopsy. , 2000, The Journal of urology.

[14]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[15]  G. Niedobitek,et al.  MRI spectroscopy in screening of prostate cancer. , 2007, Anticancer research.

[16]  Thomas Hambrock,et al.  Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen. , 2010, The Journal of urology.

[17]  D. Beyersdorff,et al.  MR imaging-guided prostate biopsy with a closed MR unit at 1.5 T: initial results. , 2005, Radiology.

[18]  L. Kiemeney,et al.  A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer , 2006, European Radiology.

[19]  A. Weaver,et al.  Prostate cancer diagnosis using a saturation needle biopsy technique after previous negative sextant biopsies. , 2001, The Journal of urology.

[20]  W. Marsden.  I and J , 2012 .

[21]  T. H. van der Kwast,et al.  Lesions predictive for prostate cancer in a screened population: First and second screening round findings , 2004, The Prostate.

[22]  Katarzyna J Macura,et al.  MR-guided biopsy of the prostate: an overview of techniques and a systematic review. , 2008, European urology.

[23]  Mark Emberton,et al.  THE ROLE OF MAGNETIC RESONANCE IMAGING IN TARGETING PROSTATE CANCER IN PATIENTS WITH PREVIOUS NEGATIVE BIOPSIES AND ELEVATED PROSTATE‐SPECIFIC ANTIGEN LEVELS , 2009, BJU international.

[24]  H M Pollack,et al.  Magnetic resonance imaging of the prostate gland , 1990, Urologic radiology.

[25]  J. Barentsz,et al.  Contrast-enhanced versus systematic transrectal ultrasound-guided prostate cancer detection: an overview of techniques and a systematic review. , 2007, European journal of radiology.

[26]  C C Schulman,et al.  Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop? , 2001, The Journal of urology.

[27]  Georg Bartsch,et al.  Comparison of contrast enhanced color Doppler targeted biopsy with conventional systematic biopsy: impact on prostate cancer detection. , 2002, The Journal of urology.

[28]  C. Magi-Galluzzi,et al.  Saturation technique does not decrease cancer detection during followup after initial prostate biopsy. , 2008, The Journal of urology.