Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
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John D. Schreier | S. Doran | G. McGaughey | J. Renger | P. Coleman | Christopher D. Cox | S. Garson | D. Reiss | C. Winrow | M. Bogusky | T. Prueksaritanont | S. Roller | Tamara D. Cabalu | A. J. Roecker | G. Hartman | S. D. Young | K. Koblan | R. Bednar | Cuyue Tang | Wei Lemaire | M. Breslin | Kathy L Murphy | D. Cui | Swati P. Mercer | Joseph G. Bruno | C. M. Harrell | D. Whitman | Wayne B Anderson