TEL and KIP 1 Define the Smallest Region of Deletions on 1 2 ~ 1 3 in Hematopoietic Malignancies

Unbalanced translocations as well as interstitial deletions of the short arm of chromosome 12 [del(l2p)l are found as recurring drromosomal changes in a broad spectrum of hematopoietic malignancies. These changes result inthe hemizygous deletion of genetic material from 12p. We mapped a yeast artificial chromosome containing the TEL gene, a cosmid contig containing part of E L and a P1 contig containing the KlPl gene to 12~13. These probes were used for fluorescence in situ hybridization to analyze samples from 47 patients with various hematologic malignancies who had unbalanced translocations (25 patients) leading to loss of 12p or deletions (22 patients) involving 12~13. The patients had acute lymphoblastic leukemia (8 cases), myelodysplastic

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