Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource

The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population.

[1]  Benjamin B. Sun,et al.  Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants , 2022, bioRxiv.

[2]  G. Zhai,et al.  Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers , 2022, Arthritis Research & Therapy.

[3]  M. Karsdal,et al.  Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers , 2021, Current opinion in rheumatology.

[4]  J. V. van Meurs,et al.  Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression , 2021, Rheumatology.

[5]  D. Gudbjartsson,et al.  The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland , 2021, Arthritis & rheumatology.

[6]  Xiaoyang Bi.  Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis , 2018, Journal of Orthopaedic Surgery and Research.

[7]  K. Pavelka,et al.  Biomarkers of hand osteoarthritis , 2018, Rheumatology International.

[8]  Xiaoling Zhang,et al.  Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis , 2017, Journal of orthopaedic translation.

[9]  Ashish Ranjan Sharma,et al.  Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis , 2017, International journal of molecular sciences.

[10]  A. Hofman,et al.  Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. , 2014, Osteoarthritis and cartilage.

[11]  J. McKeon,et al.  Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. , 2011, Osteoarthritis and cartilage.

[12]  W. Lems,et al.  Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria. , 2010, Osteoarthritis and cartilage.

[13]  A. Mobasheri,et al.  Development and use of biochemical markers in osteoarthritis: current update , 2018, Current opinion in rheumatology.