The Disc-Endplate-Bone-Marrow Complex classification: Progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

[1]  S. Rajasekaran,et al.  Are Modic changes ‘Primary infective endplatitis’?—insights from multimodal imaging of non-specific low back pain patients and development of a radiological 'Endplate infection probability score'. , 2022, European Spine Journal.

[2]  N. Farshad-Amacker,et al.  CD90-positive stromal cells associate with inflammatory and fibrotic changes in modic changes , 2022, Osteoarthritis and cartilage open.

[3]  Sakae Tanaka,et al.  Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study , 2021, Pain and Therapy.

[4]  S. Rajasekaran,et al.  "Modic Changes are Associated with Activation of Intense Inflammatory and Host Defense Response Pathways - Molecular Insights from Proteomic Analysis of Human Intervertebral Discs". , 2021, The spine journal : official journal of the North American Spine Society.

[5]  Arash J. Sayari,et al.  The Modic‐endplate‐complex phenotype in cervical spine patients: Association with symptoms and outcomes , 2021, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  Steven P. Cohen,et al.  Chronic Low Back Pain, bacterial infection and treatment with antibiotics. , 2021, The spine journal : official journal of the North American Spine Society.

[7]  S. Rajasekaran,et al.  Lumbar Disc Herniation and Preoperative Modic Changes: A Prospective Analysis of the Clinical Outcomes After Microdiscectomy , 2021, Global spine journal.

[8]  M. Skorpil,et al.  [Antibiotics should not be used for treating back pain due to Modic changes]. , 2020, Ugeskrift for læger.

[9]  S. Rajasekaran,et al.  Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease , 2020, European Spine Journal.

[10]  Jonathan E. Schmitz,et al.  A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue , 2019, European Spine Journal.

[11]  J. Lotz,et al.  Contribution of the Endplates to Disc Degeneration , 2018, Current Molecular Biology Reports.

[12]  Osahiko Tsuji,et al.  Presence of Modic type 1 change increases risk of postoperative pyogenic discitis following decompression surgery for lumbar canal stenosis. , 2017, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[13]  K. Cheung,et al.  Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes , 2017, Asian spine journal.

[14]  B. Seifert,et al.  The intervertebral disc, the endplates and the vertebral bone marrow as a unit in the process of degeneration , 2017, European Radiology.

[15]  A. Finn,et al.  Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis , 2016, Pediatric Rheumatology.

[16]  C. Manniche.  Vertebral endplate (modic) changes and the treatment of back pain using antibiotics , 2014 .

[17]  C. Manniche,et al.  Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy , 2013, European Spine Journal.

[18]  N. Wedderkopp,et al.  Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial , 2012, BMC Medicine.

[19]  D. Ganem,et al.  Viral latency and its regulation: lessons from the gamma-herpesviruses. , 2010, Cell host & microbe.

[20]  R Rahme,et al.  The Modic Vertebral Endplate and Marrow Changes: Pathologic Significance and Relation to Low Back Pain and Segmental Instability of the Lumbar Spine , 2008, American Journal of Neuroradiology.

[21]  S. Rajasekaran,et al.  ISSLS Prize Winner: A Study of Diffusion in Human Lumbar Discs: A Serial Magnetic Resonance Imaging Study Documenting the Influence of the Endplate on Diffusion in Normal and Degenerate Discs , 2004, Spine.

[22]  M. Modic,et al.  Imaging of degenerative disk disease. , 1988, Radiology.

[23]  A. Roos,et al.  MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. , 1987, AJR. American journal of roentgenology.

[24]  A. Aplogan,et al.  From the Centers for Disease Control and Prevention , 2015 .

[25]  P Kjaer,et al.  Modic changes, possible causes and relation to low back pain. , 2008, Medical hypotheses.

[26]  T J Masaryk,et al.  Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. , 1988, Radiology.