Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo

This study aimed to evaluate the inhibitory effects of Huosu Yangwei oral liquid (HSYW) on cytochrome P450 enzymes (CYPs) and to investigate whether this herbal medicine could modulate the pharmacokinetic behaviour of the co‐administered CYP‐substrate drug apatinib.

[1]  Guangbo Ge.  Deciphering the metabolic fates of herbal constituents and the interactions of herbs with human metabolic system. , 2019, Chinese journal of natural medicines.

[2]  Guangbo Ge,et al.  Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus. , 2019, Chinese journal of natural medicines.

[3]  Baofeng Yang,et al.  Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  Bing Zhang,et al.  Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  Jie Ren,et al.  Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications , 2019, Front. Pharmacol..

[6]  Yunxia Wang,et al.  Acupuncture for Premenstrual Syndrome at Different Intervention Time: A Systemic Review and Meta-Analysis , 2019, Evidence-based complementary and alternative medicine : eCAM.

[7]  Zhiqiang Zhang,et al.  The Role of Herbal Bioactive Components in Mitochondria Function and Cancer Therapy , 2019, Evidence-based complementary and alternative medicine : eCAM.

[8]  Ting Duan,et al.  Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[9]  Chen Zhang,et al.  Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma , 2019, Molecules.

[10]  X. Qu,et al.  Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  Ran Chen,et al.  Clinical efficacy of apatinib in treating metastatic gastric cancer and its effect on IL-17 , 2019, Oncology letters.

[12]  Lin Zhao,et al.  The safety of apatinib for the treatment of gastric cancer , 2018, Expert opinion on drug safety.

[13]  Ž. Debeljak,et al.  The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme , 2018, Molecules.

[14]  jinmin xue,et al.  Efficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis , 2018, OncoTargets and therapy.

[15]  Kai Cheng,et al.  Pharmacokinetic properties of wogonin and its herb-drug interactions with docetaxel in rats with mammary tumors. , 2018, Biomedical chromatography : BMC.

[16]  Xiaojun Yao,et al.  Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[17]  Shiew-Mei Huang,et al.  A regulatory science viewpoint on botanical–drug interactions , 2018, Journal of food and drug analysis.

[18]  R. V. van Breemen,et al.  Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[19]  Mingyao Liu,et al.  Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay. , 2017, Toxicology letters.

[20]  Jianbo Xiao,et al.  Flavonoids as modulators of metabolic enzymes and drug transporters , 2017, Annals of the New York Academy of Sciences.

[21]  Hyeon Kim,et al.  Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. , 2017, Bioorganic & medicinal chemistry letters.

[22]  M. Cerny.  Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015 , 2016, Drug Metabolism and Disposition.

[23]  Ruth Halsne,et al.  In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish. , 2016, Biochemical pharmacology.

[24]  Zhongqiu Liu,et al.  Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive compounds: Implication for clinical drug-drug interactions. , 2016, Journal of ethnopharmacology.

[25]  Guihua Wang,et al.  In Vitro and in Vivo Inhibitory Effects of Glycyrrhetinic Acid in Mice and Human Cytochrome P450 3A4 , 2015, International journal of environmental research and public health.

[26]  R. V. van Breemen,et al.  High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions , 2015, Drug Metabolism and Disposition.

[27]  Guangbo Ge,et al.  Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[28]  K. Fung,et al.  Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo. , 2015, Journal of ethnopharmacology.

[29]  Jin Li,et al.  Apatinib for the treatment of gastric cancer , 2015, Expert opinion on pharmacotherapy.

[30]  S. Jana,et al.  Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities , 2014, Phytotherapy research : PTR.

[31]  M. Meyer,et al.  Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse. , 2014, Toxicology letters.

[32]  M. Lam,et al.  Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro , 2014, The Journal of pharmacy and pharmacology.

[33]  Guanwei Fan,et al.  Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions. , 2013, Journal of ethnopharmacology.

[34]  J. Schellens,et al.  Effect of Chinese herbs on CYP3A4 activity and expression in vitro. , 2013, Journal of ethnopharmacology.

[35]  Xiaoyan Chen,et al.  Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans , 2013, Drug Metabolism and Disposition.

[36]  Xiaoyan Chen,et al.  Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. , 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[37]  H. Taniguchi,et al.  Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standards. , 2012, Drug metabolism and pharmacokinetics.

[38]  R. Franklin,et al.  An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS. , 2011, Drug metabolism letters.

[39]  S. Moro,et al.  Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. , 2010, Drug metabolism and pharmacokinetics.

[40]  K. Kang,et al.  Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin , 2008, Archives of pharmacal research.

[41]  S. Lim,et al.  Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. , 2006, Biopharmaceutics & drug disposition.

[42]  P. Maliakal,et al.  Effect of herbal teas on hepatic drug metabolizing enzymes in rats , 2001, The Journal of pharmacy and pharmacology.

[43]  T. Ohta,et al.  Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. , 2000, Drug metabolism and disposition: the biological fate of chemicals.

[44]  P. Coville,et al.  Effect of the Grapefruit Flavonoid Naringin on Pharmacokinetics of Quinine in Rats , 2000, Drug metabolism and drug interactions.

[45]  M. Lin,et al.  In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver. , 1999, Life sciences.