Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium

ObjectiveTo determine whether intravenous administration of gadoxetic acid disodium (Gd-EOB-DTPA) affects lesion conspicuity and apparent diffusion coefficient (ADCs) in diffusion-weighted imaging (DWI) for hepatic magnetic resonance imaging (MRI) at 3.0 T.MethodsThirty-four patients with 50 focal hepatic lesions (18 hepatocellular carcinomas, 12 metastases, 1 cholangiocarcinoma, 7 haemangiomas, 12 cysts) underwent DWI at 3.0 T before and after administration of Gd-EOB-DTPA. Non-breath-hold DWI was performed with b values of 0, 200, 400 and 800 s/mm2. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of each lesion, and ADCs of the liver and lesion were calculated for unenhanced and enhanced images. Statistical differences between unenhanced and enhanced data were assessed.ResultsSNRs and ADCs of the liver on enhanced images were significantly lower than on unenhanced images. On DW images at b = 200 s/mm2, CNRs of malignant and overall lesions were significantly higher on enhanced than on unenhanced images. CNRs of focal lesions tended to be higher, especially in malignant lesions, on DW images at b = 0 and 400 s/mm2, but without reaching statistical significance. ADCs of focal hepatic lesions were not significantly different before and after administration of contrast agent.ConclusionDWI after Gd-EOB-DTPA administration can be used as a substitute for unenhanced DWI at 3.0 T without compromising CNR and ADC of focal hepatic lesions.

[1]  E. Rummeny,et al.  Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. , 1996, Radiology.

[2]  R. Turner,et al.  Diffusion MR imaging: clinical applications. , 1992, AJR. American journal of roentgenology.

[3]  D. Mitchell,et al.  MR imaging of hepatocellular carcinoma. , 2002, Magnetic resonance imaging clinics of North America.

[4]  S. Nawano,et al.  Hepatic metastases: diffusion-weighted sensitivity-encoding versus SPIO-enhanced MR imaging. , 2006, Radiology.

[5]  Characterization of hepatic lesions by perfusion-weighted MR imaging with an echoplanar sequence. , 1998, AJR. American journal of roentgenology.

[6]  C. Ganter,et al.  Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique , 2008, European Radiology.

[7]  Echo planar MR imaging of the liver: Comparison of images with and without motion probing gradients , 2004, Journal of magnetic resonance imaging : JMRI.

[8]  V. Narra,et al.  Focal hepatic lesions: diagnostic value of enhancement pattern approach with contrast-enhanced 3D gradient-echo MR imaging. , 2005, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  G. Liu,et al.  Effect of Intravenous Gadolinium-DTPA on Diffusion-Weighted Magnetic Resonance Images for Evaluation of Focal Hepatic Lesions , 2005, Journal of computer assisted tomography.

[10]  M. Wendland,et al.  Osteogenic sarcoma: noninvasive in vivo assessment of tumor necrosis with diffusion-weighted MR imaging. , 1998, Radiology.

[11]  T. Ichikawa,et al.  Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions. , 1998, AJR. American journal of roentgenology.

[12]  E. Scurr,et al.  Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging , 2006, European Radiology.

[13]  K. Ohtomo,et al.  Breath-hold T2-weighted MRI of hepatic tumors: value of echo planar imaging with diffusion-sensitizing gradient. , 1998, Journal of computer assisted tomography.

[14]  D. Yeung,et al.  Imaging features of hepatocellular carcinoma. , 2004, Clinical radiology.

[15]  Maximilian F Reiser,et al.  MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. , 2007, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.

[16]  S. Hussain,et al.  Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation. , 2002, Radiographics : a review publication of the Radiological Society of North America, Inc.

[17]  J. Felmlee,et al.  Echo-planar imaging of the liver with a standard MR imaging system. , 1993, Radiology.

[18]  Ning-Yu An,et al.  Differentiation of clinically benign and malignant breast lesions using diffusion‐weighted imaging , 2002, Journal of magnetic resonance imaging : JMRI.

[19]  D. Collins,et al.  Diffusion-weighted MRI in the body: applications and challenges in oncology. , 2007, AJR. American journal of roentgenology.

[20]  W. Schima,et al.  Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications , 2004, European Radiology.

[21]  M. Taupitz,et al.  Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. , 1995, Radiology.

[22]  J. Mintorovitch,et al.  Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths , 2005, Investigative radiology.