Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem

It is estimated that 50 to 70 million Americans chronically suffer from a disorder of sleep and wakefulness, hindering daily functioning and adversely affecting health and longevity. The cumulative long-term effects of sleep deprivation and sleep disorders have been associated with a wide range of deleterious health consequences including an increased risk of hypertension, diabetes, obesity, depression, heart attack, and stroke. The Institute of Medicine (IOM) Committee on Sleep Medicine and Research concluded that although clinical activities and scientific opportunities in the field are expanding, awareness among the general public and health care professionals is low, given the magnitude of the burden. The available human resources and capacity are insufficient to further develop the science and to diagnose and treat individuals with sleep disorders. Therefore, the current situation necessitates a larger and more interdisciplinary workforce. Traditional scientific and medical disciplines need to be attracted into the somnology and sleep medicine field. Renewed and revitalized commitments to the field from the National Institutes of Health (NIH), academic health centers, private foundations, and professional societies are essential to ensure appropriate public and professional awareness, education and training, basic and clinical research, and patient care. Finally, the fragmentation of research and clinical care currently present in most academic institutions requires the creation of accredited interdisciplinary sleep programs in academic institutions. Copyright © National Academy of Sciences. All rights reserved. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem http://www.nap.edu/catalog/11617.html

[1]  Joseph M. Goldsen,et al.  Interdisciplinary Team Research: Methods and Problems. , 1960 .

[2]  ColinE. Sullivan,et al.  REVERSAL OF OBSTRUCTIVE SLEEP APNOEA BY CONTINUOUS POSITIVE AIRWAY PRESSURE APPLIED THROUGH THE NARES , 1981, The Lancet.

[3]  C. Guilleminault,et al.  Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia. , 1986, Sleep.

[4]  A. Hillman,et al.  Managing the physician: rules versus incentives. , 1991, Health affairs.

[5]  A I Pack,et al.  Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. , 1993, The American review of respiratory disease.

[6]  J M Harrington.  Shift work and health--a critical review of the literature on working hours. , 1994, Annals of the Academy of Medicine, Singapore.

[7]  C. Zwillich,et al.  Nasal CPAP: an objective evaluation of patient compliance. , 1994, American journal of respiratory and critical care medicine.

[8]  T. Young,et al.  Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. , 1997, Sleep.

[9]  A. Erickson,et al.  Group education sessions and compliance with nasal CPAP therapy. , 1997, Chest.

[10]  A I Pack,et al.  An instrument to measure functional status outcomes for disorders of excessive sleepiness. , 1997, Sleep.

[11]  Kathryn A. Lee,et al.  Pain, fatigue, and sleep disturbances in oncology outpatients receiving radiation therapy for bone metastasis: a pilot study. , 1999, Journal of pain and symptom management.

[12]  NIH funding of sleep research: a prospective and retrospective view. , 1999, Sleep.

[13]  H. Bøggild,et al.  Shift work, risk factors and cardiovascular disease. , 1999, Scandinavian journal of work, environment & health.

[14]  K. Sullivan.  Managed care plan performance since 1980: another look at 2 literature reviews. , 1999, American journal of public health.

[15]  K. Clark,et al.  Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community- Based Study , 2000 .

[16]  Allan I Pack,et al.  Rest in Drosophila Is a Sleep-like State , 2000, Neuron.

[17]  Y Sakaki,et al.  Resetting central and peripheral circadian oscillators in transgenic rats. , 2000, Science.

[18]  G. Tononi,et al.  Correlates of sleep and waking in Drosophila melanogaster. , 2000, Science.

[19]  Alastair Baker,et al.  Crossing the Quality Chasm: A New Health System for the 21st Century , 2001, BMJ : British Medical Journal.

[20]  J. Davidson,et al.  Nonpharmacologic group treatment of insomnia: a preliminary study with cancer survivors , 2001, Psycho-oncology.

[21]  C W Whitney,et al.  Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. , 2001, American journal of respiratory and critical care medicine.

[22]  C. Shapiro,et al.  Knowledge of Sleep Apnea in a Sample Grouping of Primary Care Physicians , 2001, Sleep and Breathing.

[23]  K J Stewart,et al.  Fatigue and quality of life outcomes of exercise during cancer treatment. , 2001, Cancer practice.

[24]  Janet Bercovitz,et al.  Organizational Structure as a Determinant of Academic Patent and Licensing Behavior: An Exploratory Study of Duke, Johns Hopkins, and Pennsylvania State Universities , 2001 .

[25]  Has the Growth of Science Crowded Out Other Things at Universities? , 2001 .

[26]  A. Rechtschaffen,et al.  Sleep deprivation in the rat: X. Integration and discussion of the findings. 1989. , 2002, Sleep.

[27]  Susan Redline,et al.  Underdiagnosis of Sleep Apnea Syndrome in U.S. Communities , 2002, Sleep and Breathing.

[28]  S. Redline,et al.  Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis , 2002, Genetic epidemiology.

[29]  L. Baur,et al.  Metabolic correlates with obstructive sleep apnea in obese subjects. , 2002, The Journal of pediatrics.

[30]  Thomas Bodenheimer,et al.  Improving primary care for patients with chronic illness. , 2002, JAMA.

[31]  Ronald G. Ehrenberg,et al.  Who Bears the Growing Cost of Science at Universities? , 2003 .

[32]  M. Adachi,et al.  Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure , 2003, Circulation.

[33]  C. Nagel,et al.  Use of complementary and alternative therapies to promote sleep in critically ill patients. , 2003, Critical care nursing clinics of North America.

[34]  D. Gozal,et al.  Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. , 2003, American journal of respiratory and critical care medicine.

[35]  B. Maher,et al.  Idiopathic congenital central hypoventilation syndrome: Analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2b , 2003, American journal of medical genetics. Part A.

[36]  T. Roth,et al.  Insomnia: epidemiology, characteristics, and consequences. , 2003, Clinical cornerstone.

[37]  L. Lavie,et al.  Obstructive sleep apnoea syndrome--an oxidative stress disorder. , 2003, Sleep medicine reviews.

[38]  Mark A. Schankerman,et al.  Incentives and Invention in Universities , 2003 .

[39]  A. Gmitro,et al.  Sleep-disordered breathing, pharyngeal size and soft tissue anatomy in children. , 2003, Journal of applied physiology.

[40]  E. Mignot,et al.  On the value of measuring CSF hypocretin-1 in diagnosing narcolepsy. , 2003, Sleep.

[41]  Sleep deprivation, residency training, and ACGME rules: practical guidelines. , 2004, The Journal of pediatrics.

[42]  Ook Joon Yoo,et al.  PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[43]  T. Young,et al.  Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index , 2004, PLoS medicine.

[44]  Haim Reuveni,et al.  Awareness level of obstructive sleep apnea syndrome during routine unstructured interviews of a standardized patient by primary care physicians. , 2004, Sleep.

[45]  Kathryn A. Lee,et al.  Impaired sleep and rhythms in persons with cancer. , 2004, Sleep medicine reviews.

[46]  W. Gozansky,et al.  Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. , 2004, The American journal of medicine.

[47]  M. Carskadon,et al.  Regulation of Adolescent Sleep: Implications for Behavior , 2004, Annals of the New York Academy of Sciences.

[48]  J. Rothschild,et al.  Effect of reducing interns' weekly work hours on sleep and attentional failures. , 2004, The New England journal of medicine.

[49]  Christopher J. Earley,et al.  Restless legs syndrome , 2003, Current treatment options in neurology.

[50]  D. Bates,et al.  Effect of reducing interns' work hours on serious medical errors in intensive care units. , 2004, The New England journal of medicine.

[51]  C. Morin,et al.  Cognitive-behavioral approaches to the treatment of insomnia. , 2004, The Journal of clinical psychiatry.

[52]  Kathryn A. Lee,et al.  Sleep and chronobiology: recommendations for nursing education. , 2004, Nursing outlook.

[53]  G. G. Alvarez,et al.  The impact of daily sleep duration on health: a review of the literature. , 2004, Progress in cardiovascular nursing.

[54]  L Ferini-Strambi,et al.  Restless legs syndrome and pregnancy , 2004, Neurology.

[55]  Debra E Weese-Mayer,et al.  Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. , 2004, The Journal of pediatrics.

[56]  Greg Maislin,et al.  Occupational screening for obstructive sleep apnea in commercial drivers. , 2004, American journal of respiratory and critical care medicine.

[57]  D. Praticò,et al.  Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output. , 2004, American journal of respiratory and critical care medicine.

[58]  D. Praticò,et al.  Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. , 2004, Sleep.

[59]  J. Ficker,et al.  Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. , 2004, American journal of respiratory and critical care medicine.

[60]  D. Gozal,et al.  Increased upper airway collapsibility in children with obstructive sleep apnea during wakefulness. , 2004, American journal of respiratory and critical care medicine.

[61]  S. Redline,et al.  Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. , 2004, American journal of epidemiology.

[62]  Anup V. Desai,et al.  Sleepiness, sleep-disordered breathing, and accident risk factors in commercial vehicle drivers. , 2004, American journal of respiratory and critical care medicine.

[63]  K. Spiegel,et al.  Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite , 2004, Annals of Internal Medicine.

[64]  C. Miaskowski.  Gender differences in pain, fatigue, and depression in patients with cancer. , 2004, Journal of the National Cancer Institute. Monographs.

[65]  D. Gozal,et al.  Plasma C-reactive protein levels among children with sleep-disordered breathing. , 2004, Pediatrics.

[66]  T. Young,et al.  APOE ε4 is associated with obstructive sleep apnea/hypopnea , 2004, Neurology.

[67]  E. Katz,et al.  Upper Airway Dynamic Responses in Children with the Obstructive Sleep Apnea Syndrome , 2005, Pediatric Research.

[68]  N. Cherniack.  Sleep Apnea and Insomnia: Sleep Apnea Plus or Sleep Apnea Minus , 2005, Respiration.

[69]  K. Chung.  Insomnia Subtypes and Their Relationships to Daytime Sleepiness in Patients with Obstructive Sleep Apnea , 2005, Respiration.

[70]  C. Saper,et al.  Hypothalamic regulation of sleep and circadian rhythms , 2005, Nature.

[71]  T. Monk,et al.  Aging Human Circadian Rhythms: Conventional Wisdom May Not Always Be Right , 2005, Journal of biological rhythms.

[72]  Sally C Morton,et al.  A meta-analysis of interventions to improve care for chronic illnesses. , 2005, The American journal of managed care.

[73]  S. Daniels,et al.  Left ventricular function in children with sleep-disordered breathing. , 2005, The American journal of cardiology.

[74]  P. Clark,et al.  Symptom interactions as mechanisms underlying symptom pairs and clusters. , 2005, Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing.

[75]  P. Chambon,et al.  Retinoic Acid Signaling Affects Cortical Synchrony During Sleep , 2005, Science.

[76]  E. Mignot,et al.  A link between short sleep and obesity: building the evidence for causation. , 2005, Sleep.

[77]  S. Redline,et al.  Variation of C-Reactive Protein Levels in Adolescents: Association With Sleep-Disordered Breathing and Sleep Duration , 2005, Circulation.

[78]  J. Concato,et al.  Obstructive sleep apnea as a risk factor for stroke and death. , 2005, The New England journal of medicine.

[79]  Jose M Marin,et al.  Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study , 2005, The Lancet.

[80]  J. Siegel,et al.  Animal behaviour: Continuous activity in cetaceans after birth , 2005, Nature.

[81]  F. Speizer,et al.  Extended work shifts and the risk of motor vehicle crashes among interns. , 2005, The New England journal of medicine.

[82]  D. White,et al.  A quantitative assessment of sleep laboratory activity in the United States. , 2005, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[83]  Susan Redline,et al.  Association of sleep time with diabetes mellitus and impaired glucose tolerance. , 2005, Archives of internal medicine.

[84]  W. Riley,et al.  NIH State-of-the-Science Conference on Chronic Insomnia. , 2005, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[85]  Steven A. Brown,et al.  The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals , 2005, PLoS biology.

[86]  R. Benca.  Diagnosis and treatment of chronic insomnia: a review. , 2005, Psychiatric services.

[87]  D. Dinges,et al.  Modafinil for excessive sleepiness associated with shift-work sleep disorder. , 2005, The New England journal of medicine.

[88]  Ying Xu,et al.  Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome , 2005, Nature.

[89]  Fred W. Turek,et al.  Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice , 2005, Science.

[90]  G. Aston-Jones,et al.  A role for lateral hypothalamic orexin neurons in reward seeking , 2005, Nature.

[91]  S. Redline,et al.  Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak , 2006, Genetic epidemiology.

[92]  Sarah A. Bunton.  Recent Trends in Basic Science Department Reorganizations , 2006 .

[93]  J. Wilson,et al.  Insomnia , 1899, Annals of Internal Medicine.