Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia.

We describe a case of pediatric acute lymphoblastic leukemia (ALL) with trisomy 5 as a sole cytogenetic abnormality. A comparison is made with the two cases of adult acute lymphoblastic leukemia with trisomy 5 in the literature. This rare cytogenetic abnormality may portend an especially poor prognosis in patients with ALL.

[1]  C. Pui.  Medical progress : childhood leukemias , 1995 .

[2]  S. Kwok,et al.  Avoiding false positives with PCR , 1989, Nature.

[3]  R. Ríos,et al.  A new case of trisomy 5 as sole cytogenetic anomaly in acute myeloid leukemia. , 1995, Cancer genetics and cytogenetics.

[4]  A. Sandberg,et al.  Trisomy 5 as sole anomaly in acute lymphoblastic leukemia. , 1988, Cancer genetics and cytogenetics.

[5]  Iscn.  International System for Human Cytogenetic Nomenclature , 1978 .

[6]  J. Testa,et al.  Chromosomal alterations in acute leukemia patients studied with improved culture methods. , 1985, Cancer research.

[7]  P. N. Rao,et al.  Trisomy 5 as the sole abnormality in acute lymphoblastic leukemia. A second case and review. , 1994, Cancer genetics and cytogenetics.

[8]  C. Pui,et al.  Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  D. Johnston,et al.  Measurement of residual leukemia during remission in childhood acute lymphoblastic leukemia. , 1997, The New England journal of medicine.

[10]  L. Chan,et al.  Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones. , 1998, Leukemia research.

[11]  Hyperdiploid (47-50) acute lymphoblastic leukemia in children. , 1992 .

[12]  H. Cavé,et al.  Clinical Significance of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia , 1998 .