Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients
暂无分享,去创建一个
C. Collins | S. Volik | M. Gleave | A. Wyatt | P. Rennie | Kriti Singh | A. Cherkasov | S. Awrey | K. Chi | A. Azad | N. Lallous | E. Leblanc | J. Murillo | R. Tse | Stéphane Lebihan
[1] Delila Gasi Tandefelt,et al. Plasma AR and abiraterone-resistant prostate cancer , 2015, Science Translational Medicine.
[2] P. Rennie,et al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. , 2015, The Journal of Biological Chemistry.
[3] Lawrence D. True,et al. Integrative Clinical Genomics of Advanced Prostate Cancer , 2015, Cell.
[4] Dustin R. Bunch,et al. Conversion of abiraterone to D4A drives antitumor activity in prostate cancer , 2015, Nature.
[5] Martin E. Gleave,et al. Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer , 2015, Clinical Cancer Research.
[6] A. Zoubeidi,et al. Identification of a potent antiandrogen that targets the BF3 site of the androgen receptor and inhibits enzalutamide-resistant prostate cancer. , 2014, Chemistry & biology.
[7] M. Gleave,et al. Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer , 2014, Molecular Cancer Therapeutics.
[8] M. Loda,et al. Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors , 2014, Clinical Cancer Research.
[9] F. Saad,et al. Enzalutamide in metastatic prostate cancer before chemotherapy. , 2014, The New England journal of medicine.
[10] P. Rennie,et al. Discovery of 1H-indole-2-carboxamides as novel inhibitors of the androgen receptor binding function 3 (BF3). , 2014, Journal of medicinal chemistry.
[11] Myles A Brown,et al. Coregulator Control of Androgen Receptor Action by a Novel Nuclear Receptor-binding Motif* , 2014, The Journal of Biological Chemistry.
[12] Gang Shao,et al. A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509. , 2013, Cancer discovery.
[13] Joshua M. Korn,et al. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). , 2013, Cancer discovery.
[14] P. Rennie,et al. Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer , 2013, International journal of molecular sciences.
[15] V. Arora,et al. Overcoming mutation-based resistance to antiandrogens with rational drug design , 2013, eLife.
[16] O. Sartor,et al. Enzalutamide for the treatment of prostate cancer , 2013, Expert opinion on pharmacotherapy.
[17] Artem Cherkasov,et al. Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives. , 2013, Journal of medicinal chemistry.
[18] J. Hoffman-Censits,et al. Enzalutamide: A Novel Antiandrogen for Patients with Castrate-Resistant Prostate Cancer , 2013, Clinical Cancer Research.
[19] N. Vogelzang. Enzalutamide--a major advance in the treatment of metastatic prostate cancer. , 2012, The New England journal of medicine.
[20] Tapio Visakorpi,et al. Androgen receptor (AR) aberrations in castration-resistant prostate cancer , 2012, Molecular and Cellular Endocrinology.
[21] Helga Thorvaldsdóttir,et al. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration , 2012, Briefings Bioinform..
[22] H. Scher,et al. ARN-509: a novel antiandrogen for prostate cancer treatment. , 2012, Cancer research.
[23] Artem Cherkasov,et al. Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. , 2011, Journal of medicinal chemistry.
[24] D. Tindall,et al. Alternatively spliced androgen receptor variants. , 2011, Endocrine-related cancer.
[25] R. Fletterick,et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells , 2011, Proceedings of the National Academy of Sciences.
[26] Klaus Pantel,et al. Cell-free nucleic acids as biomarkers in cancer patients , 2011, Nature Reviews Cancer.
[27] Arturo Molina,et al. Abiraterone and increased survival in metastatic prostate cancer. , 2011, The New England journal of medicine.
[28] N. Socci,et al. Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor , 2010, Proceedings of the National Academy of Sciences.
[29] J. Humm,et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study , 2010, The Lancet.
[30] Guido Jenster,et al. Systematic Structure-Function Analysis of Androgen Receptor Leu701 Mutants Explains the Properties of the Prostate Cancer Mutant L701H* , 2009, The Journal of Biological Chemistry.
[31] K. Pantel,et al. Cell-free Tumor DNA in Blood Plasma As a Marker for Circulating Tumor Cells in Prostate Cancer , 2009, Clinical Cancer Research.
[32] P. Nelson,et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. , 2008, Cancer research.
[33] Phuong Nguyen,et al. A surface on the androgen receptor that allosterically regulates coactivator binding , 2007, Proceedings of the National Academy of Sciences.
[34] Vishnu Swarup,et al. Circulating (cell‐free) nucleic acids – A promising, non‐invasive tool for early detection of several human diseases , 2007, FEBS letters.
[35] D. Jacqmin,et al. Unfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer , 2006, Cellular and Molecular Life Sciences CMLS.
[36] I. McEwan,et al. Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions. , 2005, Molecular endocrinology.
[37] Duane D. Miller,et al. Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor* , 2005, Journal of Biological Chemistry.
[38] H. Scher,et al. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[39] J. Dalton,et al. Chemistry and structural biology of androgen receptor. , 2005, Chemical reviews.
[40] Duane D. Miller,et al. Structural basis for antagonism and resistance of bicalutamide in prostate cancer , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[41] Bin He,et al. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. , 2004, Molecular cell.
[42] Desok Kim,et al. The Androgen Axis in Recurrent Prostate Cancer , 2004, Clinical Cancer Research.
[43] P. Kantoff,et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[44] Donna M. Peehl,et al. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor , 2000, Nature Medicine.
[45] E. Small,et al. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. , 1999, Cancer research.
[46] G. Bubley,et al. Functional characterization of mutant androgen receptors from androgen-independent prostate cancer. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[47] G. Bubley,et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. , 1995, The New England journal of medicine.
[48] H. Klocker,et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. , 1993, Molecular endocrinology.
[49] N. Sato,et al. Androgen receptor gene mutations in human prostate cancer , 1993, The Journal of Steroid Biochemistry and Molecular Biology.
[50] W. Isaacs,et al. Androgen receptor gene mutations in human prostate cancer. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[51] T. H. van der Kwast,et al. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. , 1991, Molecular endocrinology.
[52] G. Jenster,et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. , 1990, Biochemical and biophysical research communications.
[53] J. Bono,et al. Switching and withdrawing hormonal agents for castration-resistant prostate cancer , 2015, Nature Reviews Urology.
[54] Hideo Araki,et al. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. , 2003, Cancer research.
[55] D. Peehl,et al. Erratum: Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor (Nature Medicine (2000) 6 (703-706)) , 2000 .
[56] L. Denis,et al. Pharmacodynamics and pharmacokinetics of bicalutamide: defining an active dosing regimen. , 1996, Urology.