The nonconservative CD177 single‐nucleotide polymorphism c.1291G>A is a genetic determinant for human neutrophil antigen‐2 atypical/low expression and deficiency

Human neutrophil antigen‐2 (HNA‐2) is exclusively expressed on neutrophils. HNA‐2–deficient individuals (HNA‐2 null) are susceptible to produce isoantibodies. The nonsense CD177 coding single‐nucleotide polymorphism (SNP) c.787A>T has been demonstrated as the primary genetic mechanism for HNA‐2 deficiency. We hypothesized that the other genetic variants also contribute to HNA‐2 expression variation and deficiency.

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