Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin?

Gold‐standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue. However, this process is invasive with recognized side‐effects. Optical coherence tomography (OCT) is a noninvasive technique generating high‐resolution real‐time images of cutaneous architecture.

[1]  M. Selman,et al.  Expression of matrix metalloproteases by fibrocytes: possible role in migration and homing. , 2010, American journal of respiratory and critical care medicine.

[2]  Yingtian Pan,et al.  Optical coherence tomography: a noninvasive method to assess wound reepithelialization. , 2007, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[3]  A B Wysocki,et al.  WOUND MEASUREMENT , 1996, International journal of dermatology.

[4]  A. Bayat,et al.  The role of skin substitutes in the management of chronic cutaneous wounds , 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[5]  Barry Cense,et al.  Advances in optical coherence tomography imaging for dermatology. , 2004, The Journal of investigative dermatology.

[6]  A. Kruize,et al.  When and how to perform biopsies in a patient with a (suspected) connective tissue disease. , 2013, Best practice & research. Clinical rheumatology.

[7]  A. Bayat,et al.  Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. , 2013, Journal of dermatological science.

[8]  E. Sattler,et al.  Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy. , 2013, Journal of the American Academy of Dermatology.

[9]  Thilo Gambichler,et al.  Applications of optical coherence tomography in dermatology. , 2005, Journal of dermatological science.

[10]  Barry Cense,et al.  Birefringence measurements in human skin using polarization-sensitive optical coherence tomography. , 2004, Journal of biomedical optics.

[11]  Thilo Gambichler,et al.  Comparison of histometric data obtained by optical coherence tomography and routine histology. , 2005, Journal of biomedical optics.

[12]  T. Gambichler,et al.  Optical coherence tomography in dermatology: technical and clinical aspects , 2011, Archives of Dermatological Research.

[13]  T. Gambichler,et al.  In vivo data of epidermal thickness evaluated by optical coherence tomography: effects of age, gender, skin type, and anatomic site. , 2006, Journal of dermatological science.

[14]  J. Welzel.  Optical coherence tomography in dermatology: a review , 2001, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[15]  Xingde Li,et al.  Noninvasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography. , 2006, Journal of biomedical optics.

[16]  Jürgen Lademann,et al.  Evaluation of optical coherence tomography as a non‐invasive diagnostic tool in cutaneous wound healing , 2014, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[17]  P Wilson,et al.  Wound healing assessment using 20 MHz ultrasound and photography , 2003, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[18]  Jingxuan Liu,et al.  Assessment of dermal wound repair after collagen implantation with optical coherence tomography. , 2008, Tissue engineering. Part C, Methods.

[19]  H H Wolff,et al.  Changes in function and morphology of normal human skin: evaluation using optical coherence tomography , 2004, The British journal of dermatology.

[20]  R. Bucala,et al.  Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  Beop-Min Kim,et al.  Quantification of the wound healing using polarization-sensitive optical coherence tomography. , 2006, Journal of biomedical optics.

[22]  J. Sanes,et al.  Non-invasive visualization of epidermal responses to injury using a fluorescent transgenic reporter. , 2004, The Journal of investigative dermatology.

[23]  R. Kreis,et al.  Confocal laser scanning microscopy of porcine skin: implications for human wound healing studies , 1997, Journal of anatomy.

[24]  H Ermert,et al.  Comparison of High Frequency Ultrasound and Optical Coherence Tomography as Modalities for High Resolution and Non Invasive Skin Imaging. Vergleich von hochfrequentem Ultraschall und optischer Kohärenztomographie als Modalitäten für die hochauflösende und nichtinvasive Abbildung der Haut , 2003, Biomedizinische Technik. Biomedical engineering.

[25]  M. Horžić,et al.  Contact Thermography in a study of primary healing of surgical wounds. , 1996, Ostomy/wound management.

[26]  J M Bland,et al.  Statistical methods for assessing agreement between two methods of clinical measurement , 1986 .