Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans

Endogenous nitric oxide (NO) is thought to regulate many biological functions, including pulmonary circulation and bronchomotion, and it has been found in exhaled air. Our aim was to study the excretion of NO in different parts of the respiratory system.

[1]  L. Gustafsson,et al.  Oxygen or low concentrations of nitric oxide reverse pulmonary vasoconstriction induced by nitric oxide synthesis inhibition in rabbits. , 1994, Acta physiologica Scandinavica.

[2]  L. Gustafsson,et al.  Detection of nitric oxide in exhaled air during administration of nitroglycerin in vivo , 1994, British journal of pharmacology.

[3]  R. Rossaint,et al.  Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx , 1994, The Lancet.

[4]  P. J. Barnes,et al.  Increased nitric oxide in exhaled air of asthmatic patients , 1994, The Lancet.

[5]  O. Zetterström,et al.  Single-breath nitric oxide measurements in asthmatic patients and smokers , 1994, The Lancet.

[6]  L. Gustafsson,et al.  Allergen-induced airway obstruction in guinea-pigs is associated with changes in nitric oxide levels in exhaled air. , 1993, Acta physiologica Scandinavica.

[7]  P. Hedqvist,et al.  Endogenous nitric oxide counteracts antigen-induced bronchoconstriction. , 1993, European journal of pharmacology.

[8]  N. Wiklund,et al.  Endogenous nitric oxide in single exhalations and the change during exercise. , 1993, The American review of respiratory disease.

[9]  J. Stamler,et al.  Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. , 1993, American journal of respiratory cell and molecular biology.

[10]  E. Weitzberg,et al.  Increased amount of nitric oxide in exhaled air of asthmatics. , 1993, The European respiratory journal.

[11]  R. Rossaint,et al.  Time‐course and dose‐response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome , 1993, European journal of clinical investigation.

[12]  E. Shaffer,et al.  Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. , 1993, The Journal of pediatrics.

[13]  G. Andersson.  The Swedish modification of the tracheostomy tube to permit speech , 1993, Paraplegia.

[14]  G. Hedenstierna,et al.  Inhaled Nitric Oxide Selectively Reverses Human Hypoxic Pulmonary Vasoconstriction without Causing Systemic Vasodilation , 1993, Anesthesiology.

[15]  R. Rossaint,et al.  Inhaled nitric oxide for the adult respiratory distress syndrome. , 1993, The New England journal of medicine.

[16]  P. López-Jaramillo,et al.  The L-arginine: nitric oxide pathway. , 1993, Current opinion in nephrology and hypertension.

[17]  C. N. Gillis,et al.  Pulmonary vasodilation by inhaled nitric oxide after endothelial injury. , 1992, Journal of applied physiology.

[18]  Jesse D. Roberts,et al.  Inhaled nitric oxide in persistent pulmonary hypertension of the newborn , 1992, The Lancet.

[19]  C. Thiemermann,et al.  Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Yacoub,et al.  Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. , 1992, European journal of pharmacology.

[21]  S Moncada,et al.  Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. , 1991, Biochemical and biophysical research communications.

[22]  T. Higenbottam,et al.  Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension , 1991, The Lancet.

[23]  J. Wain,et al.  Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator Reversing Hypoxic Pulmonary Vasoconstriction , 1991, Circulation.

[24]  S. Moncada,et al.  Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. , 1990, Acta physiologica Scandinavica.

[25]  B. Lehnert,et al.  NITRIC OXIDE AND NITROGEN DIOXIDE AS INDUCERS OF ACUTE PULMONARY INJURY WHEN INHALED AT RELATIVELY HIGH CONCENTRATIONS FOR BRIEF PERIODS , 1990 .

[26]  J F Murray,et al.  An expanded definition of the adult respiratory distress syndrome. , 1988, The American review of respiratory disease.

[27]  K. Teranishi,et al.  Induction of mutations and chromosome aberrations in lung cells following in vivo exposure of rats to nitrogen oxides. , 1984, Mutation research.

[28]  C. Hugod.  Effect of exposure to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide on rabbit lung , 1979, International archives of occupational and environmental health.

[29]  G. R. Kelman,et al.  Effects of higher oxides of nitrogen on the anaesthetized dog. , 1967, British journal of anaesthesia.