Welcome to the 18th Annual International Conference on Computational Science (ICCS https://www.iccs-meeting.org/iccs2018/), to be held on June 11-13, 2018 in Wuxi, China. Located in the Jiangsu province, Wuxi is bordered by Changzhou to the west and Suzhou to the east. The city meets the Yangtze River in the north and is bathed by Lake Tai to the south. Wuxi is home to many parks, gardens, temples, and the fastest supercomputer in the world, the Sunway TaihuLight. ICCS 2018 is jointly organized by University of Chinese Academy of Sciences, National Supercomputing Center in Wuxi, University of Amsterdam, NTU Singapore and the University of Tennessee. The International Conference on Computational Science is an annual conference that brings together researchers and scientists from mathematics and computer science as basic computing disciplines, researchers from various application areas who are pioneering computational methods in sciences such as physics, chemistry, life sciences, and engineering, as well as in arts and humanitarian fields, to discuss problems and solutions in the area, to identify new issues, and to shape future directions for research. Since its inception in 2001, ICCS has attracted increasingly higher quality and numbers of attendees and papers, and this year is not an exception, with over 350 expected participants. The proceedings series have become a major intellectual resource for computational science researchers, defining and advancing the state of the art in this field. ICCS 2018 in Wuxi, China, will be the eighteenth in this series of highly successful conferences. For the previous seventeen meetings see: http://www.iccs-meeting.org/iccs2018/previous-iccs/ . The theme for ICCS 2018 is "Science at the Intersection of Data, Modelling and Computation", to highlight the role of computation as a fundamental method of scientific inquiry and technological discovery tackling problems across scientific domains and creating synergies between disciplines. This conference will be a unique event focusing on recent developments in: scalable scientific algorithms; advanced software tools; computational grids; advanced numerical methods; and novel application areas. These innovative novel models, algorithms and tools drive new science through efficient application in areas such as physical systems, computational and systems biology, environmental systems, finance, and others. ICCS is well known for its excellent line up of keynote speakers. The keynotes for 2018 are: Charlie Catlett, Argonne National Laboratory | University of Chicago, USA