Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
暂无分享,去创建一个
Vanessa Taupin | Donald B Kohn | P. Gregory | M. Holmes | G. Crooks | D. Kohn | P. Cannon | Jianbin Wang | Kenneth A Kim | G. Friedman | Jianbin Wang | Philip D Gregory | Michael C Holmes | V. Taupin | Xingchao Wang | X. Wang | Gay M Crooks | Nathalia Holt | Kenneth Kim | Geoffrey Friedman | Paula M Cannon | Nathalia Holt | Philip D. Gregory | Jianbin Wang | Donald B. Kohn | Xingchao Wang | Vanessa Taupin | Donald B Kohn | Paula M Cannon
[1] F. Candotti,et al. Revertant somatic mosaicism in the Wiskott–Aldrich syndrome , 2009, Immunologic research.
[2] C. Barbas,et al. T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery , 2007, Gene Therapy.
[3] Xavier Anglaret,et al. Transfer and Evaluation of an Automated, Low-Cost Real-Time Reverse Transcription-PCR Test for Diagnosis and Monitoring of Human Immunodeficiency Virus Type 1 Infection in a West African Resource-Limited Setting , 2005, Journal of Clinical Microbiology.
[4] T. Klimkait,et al. HIV-1 coreceptor usage and CXCR4-specific viral load predict clinical disease progression during combination antiretroviral therapy , 2008, AIDS.
[5] Joseph Sodroski,et al. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 , 1996, Nature.
[6] E. Thiel,et al. Transplantation of selected or transgenic blood stem cells – a future treatment for HIV/AIDS? , 2009, Journal of the International AIDS Society.
[7] Mario Roederer,et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection , 2005, Nature.
[8] Manfred Schmidt,et al. Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy , 2009, Science.
[9] H. Schuitemaker,et al. R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression , 2005, Journal of Virology.
[10] D. McDermott,et al. CCR5 deficiency increases risk of symptomatic West Nile virus infection , 2006, The Journal of experimental medicine.
[11] D. Douek,et al. HIV disease: fallout from a mucosal catastrophe? , 2006, Nature Immunology.
[12] Michael Dean,et al. CCR2 chemokine receptor and AIDS progression , 1997, Nature Medicine.
[13] B. Palmer,et al. Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[14] Alessandro Aiuti,et al. Gene therapy for immunodeficiency due to adenosine deaminase deficiency. , 2009, The New England journal of medicine.
[15] Jeffrey C. Miller,et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases , 2005, Nature.
[16] M. Rossol,et al. Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis , 2009, Arthritis research & therapy.
[17] J. McCune,et al. IFN-α-Induced Upregulation of CCR5 Leads to Expanded HIV Tropism In Vivo , 2010, PLoS pathogens.
[18] B. Walker,et al. Acute human immunodeficiency virus type 1 infection. , 1998, The New England journal of medicine.
[19] B. Palmer,et al. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/- (RAG-hu) mouse model , 2006, Retrovirology.
[20] A. Lackner,et al. The mucosal immune system: primary target for HIV infection and AIDS. , 2001, Trends in immunology.
[21] V. Appay,et al. Immune activation and inflammation in HIV‐1 infection: causes and consequences , 2008, The Journal of pathology.
[22] B. Weinshenker,et al. CCR5Δ32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis , 2005, Journal of Neuroimmunology.
[23] Qingsheng Li,et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells , 2005, Nature.
[24] Christof von Kalle,et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. , 2009, Nature medicine.
[25] Boris Jerchow,et al. Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates , 2009, Nature Genetics.
[26] T. Hocking,et al. Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases , 2008, Nature Biotechnology.
[27] E. Thiel,et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. , 2009, The New England journal of medicine.
[28] I. Charo,et al. A Mechanism for the Impaired IFN-γ Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses1 , 2000, The Journal of Immunology.
[29] T. Morio,et al. Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses , 2007 .
[30] G. Crooks,et al. Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. , 2009, Human gene therapy.
[31] M. Tankersley,et al. T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice , 2009, Pediatrics.
[32] J. Flamm,et al. Severe CD4+ T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy , 2003, Journal of Virology.
[33] B. Torbett,et al. Can gene delivery close the door to HIV‐1 entry after escape? , 2006, Journal of medical primatology.
[34] J. Church. CD4+ T Cell Depletion During All Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract , 2005, Pediatrics.
[35] M. Kotb,et al. Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12 , 2004, The Journal of Immunology.
[36] J. Mellors,et al. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy , 2008, Proceedings of the National Academy of Sciences.
[37] K. Akashi,et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice , 2005 .
[38] M. Jasin,et al. Genetic manipulation of genomes with rare-cutting endonucleases. , 1996, Trends in genetics : TIG.
[39] S J Gange,et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy , 2009, Proceedings of the National Academy of Sciences.
[40] J. Howe,et al. Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120. , 2008, Virology.
[41] Jerome H. Carter,et al. Distribution of health care expenditures for HIV-infected patients. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[42] J. Margolick,et al. Impact of Inversion of the CD4/CD8 Ratio on the Natural History of HIV-1 Infection , 2006, Journal of acquired immune deficiency syndromes.
[43] J. Puck,et al. Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency , 1996, Nature Genetics.
[44] A. Lackner,et al. The gastrointestinal tract and AIDS pathogenesis. , 2009, Gastroenterology.
[45] L. Picker. Immunopathogenesis of acute AIDS virus infection. , 2006, Current opinion in immunology.
[46] John J Rossi,et al. Genetic therapies against HIV , 2007, Nature Biotechnology.
[47] A. Nademanee,et al. Autologous stem cell transplantation for HIV-associated lymphoma. , 2001, Blood.
[48] M. Holodniy,et al. Novel Targets for Antiretroviral Therapy , 2009, Drugs.
[49] John Novembre,et al. The Geographic Spread of the CCR5 Δ32 HIV-Resistance Allele , 2005, PLoS biology.
[50] D. Nickle,et al. Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. , 2008, The Journal of infectious diseases.
[51] H. Jessen,et al. CCR5Δ32 Genotypes in a German HIV-1 Seroconverter Cohort and Report of HIV-1 Infection in a CCR5Δ32 Homozygous Individual , 2008, PloS one.
[52] Dale L. Greiner,et al. T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice , 2008, Cell.
[53] J. Rossi,et al. Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[54] Yang Du,et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 , 2006, Nature Medicine.
[55] H. Broxmeyer,et al. CCR5 Ligands Modulate CXCL12-Induced Chemotaxis, Adhesion, and Akt Phosphorylation of Human Cord Blood CD34+ Cells1 , 2009, The Journal of Immunology.
[56] U. Dirksen,et al. Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. , 1996, The New England journal of medicine.
[57] Shunichi Takeda,et al. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. , 2006, DNA repair.
[58] R P Johnson,et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. , 1998, Science.
[59] J. Orange,et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases , 2008, Nature Biotechnology.
[60] J. Wagner,et al. Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. , 2009, Blood.
[61] A. Mortellaro,et al. Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning , 2002, Science.
[62] A. Klug,et al. Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases , 2008, Proceedings of the National Academy of Sciences.
[63] Dana Carroll,et al. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. , 2002, Genetics.
[64] M. Zupancic,et al. Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1 , 2007, The Journal of experimental medicine.
[65] Xiuli Wang,et al. Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon. , 2006, Experimental hematology.
[66] R. Hirschhorn. In vivo reversion to normal of inherited mutations in humans , 2003, Journal of medical genetics.
[67] J J Goedert,et al. Natural history of HIV-1 cell-free viremia. , 1995, JAMA.
[68] V. Calvez,et al. Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients , 2008, AIDS.
[69] Marc Parmentier,et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene , 1996, Nature.
[70] Luigi Naldini,et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery , 2007, Nature Biotechnology.
[71] B. Bennetts,et al. HIV-1 infection in an individual homozygous for the CCR5 deletion allele , 1997, Nature Medicine.
[72] M R Loken,et al. Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry. , 1990, Cytometry.
[73] C. Irwin,et al. Effect of HIV‐1 Infection on Lymphocyte Proliferation in Gut‐Associated Lymphoid Tissue , 2001, Journal of acquired immune deficiency syndromes.
[74] D. Hazuda,et al. The Challenge of Finding a Cure for HIV Infection , 2009, Science.
[75] H. Schuitemaker,et al. CC chemokine receptor 5 cell-surface expression in relation to CC chemokine receptor 5 genotype and the clinical course of HIV-1 infection. , 1999, Journal of immunology.