Emergence of antidepressant induced suicidality

. .~ :; Introduction ., ." rn 1990, Teicher and coJle:lgues reponed on the emergence of stlici­ dali.ty on fluoxcrine in ;l group of :;bc patients Ill · These reporrs wt:re fol­ lowed-up by r(.'ports from King ei aL 121, Creanq et aL [3j. RothschHd and Locke [4) and Wir.;hing et aL 151. :unong omen;, reporting other cases where suiddaliry appeared to emerge in individuals raking fluoxt:tine. There were a number of fuctor.> associated with these: t:lse report.'i that argued for do scrong C:1I.~a1 connection. In general there was consi:;rency across che ["(.:pores as to me time of unset of the problems following intake of nuoxetim:. I'here appe:ared (0 he a do:;e respon:;e relationship wieh pmblems liable co emerge on a highc:r close. There wa:; some agreement as rcg;u:-ds (he: probable mechanism l=ding to the difficulties. This was termed akarhiSia, although whether it was quite rhe same phe.:nomenon as akathisia tr.lciitionali5-as-sociatcd with neuroleptics W"as kss clear. The phe· In the conrse ofa randomised doobl~bli1ld a'OssoV(:r study comparilIg the effect5 of rebox.ctine and.sertralin.c in a group of healthy voluntccr.!i, [W() volonte=s ~camc sW(:ida! on sertralineThis paper d.escrlbes tlle cb=ac­ tcrlstlc=s Of the reactions experienced by both subjects. These problems were associared with ;:a combination of akath1sla aud disinltibition.. ~ric or akathisic respow;es on their own to either drug did not lead Co suIdda1.ity in this group of subjects. I'rim3ry Coo", 1'5}d1'"rry 2000: 6:l~28, Wpyrigtu: (:l ZOOO by l.ibrolPlurm UlnilCtl