Perfluorooctane sulfonic acid is a potent inducer of peroxisomal fatty acid beta-oxidation and other activities known to be affected by peroxisome proliferators in mouse liver.

Perfluorooctane sulfonic acid is almost as potent as perfluorooctanoic acid in causing increases in peroxisomal fatty acid beta-oxidation, peroxisomal catalase activity, omega-hydroxylation of lauric acid, cytosolic epoxide hydrolase activity and cytosolic DT-diaphorase activity. Octane sulfonic acid was ineffective at doses used for perfluorooctane sulfonic acid and perfluorooctanoic acid. The results support the theory of co-regulation of these parameters and peroxisome proliferation. The fact that perfluorooctane sulfonic acid causes peroxisome proliferation challenges the hypothesis that the first step in this process is formation of a thioester between the proliferator (the carboxylic group) and coenzyme A.

[1]  K P Lee,et al.  Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation. , 1987, Experimental and molecular pathology.

[2]  J. Depierre,et al.  Effects of dietary treatment with clofibrate, nafenopin or WY-14.643 on mitochondria and DNA in mouse liver. , 1990, Biochimica et biophysica acta.

[3]  C. Duve,et al.  A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Depierre,et al.  Cytosolic epoxide hydrolase. , 1988, Chemico-biological interactions.

[5]  B. Lake,et al.  Peroxisome proliferation in primary cultures of rat hepatocytes. , 1983, Toxicology and applied pharmacology.

[6]  B. Hammock,et al.  Radiometric assays for mammalian epoxide hydrolases and glutathione S-transferase. , 1983, Analytical biochemistry.

[7]  B. Hammock,et al.  Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities. , 1983, Toxicology and applied pharmacology.

[8]  Reddy Jk,et al.  Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans , 1983 .

[9]  D. Touchard,et al.  Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate. , 1986, Biochemical pharmacology.

[10]  R. Berge,et al.  Alkylthioacetic acid (3-thia fatty acids)--a new group of non-beta-oxidizable, peroxisome-inducing fatty acid analogues. I. A study on the structural requirements for proliferation of peroxisomes and mitochondria in rat liver. , 1989, Biochimica et biophysica acta.

[11]  M. Bronfman,et al.  Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters. , 1986, The Biochemical journal.

[12]  P. Grasso,et al.  Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man. , 1981, Food and cosmetics toxicology.

[13]  W B Jakoby,et al.  Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. , 1974, The Journal of biological chemistry.

[14]  M E Andersen,et al.  Pathological and hepatic ultrastructural effects of a single dose of perfluoro-n-decanoic acid in the rat, hamster, mouse, and guinea pig. , 1987, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[15]  L. Ernster,et al.  DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties. , 1962, Biochimica et biophysica acta.

[16]  T. Orton,et al.  Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). , 1982, The Biochemical journal.

[17]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[18]  J. Depierre,et al.  Preparation and characterization of subcellular fractions from the liver of C57B1/6 mice, with special emphasis on their suitability for use in studies of epoxide hydrolase activities. , 1987, Biochemical pharmacology.

[19]  J. Depierre,et al.  Perfluorooctanoic acid has persistent effects on peroxisome proliferation and related parameters in mouse liver. , 1992, Journal of biochemical toxicology.

[20]  T. Suga,et al.  Induction of Cytochrome P-450 and Peroxisome Proliferation in Rat Liver by Perfluorinated Octane Sulphonic Acid (PFOS) , 1987 .

[21]  E. Lock,et al.  Biochemical mechanisms of induction of hepatic peroxisome proliferation. , 1989, Annual review of pharmacology and toxicology.

[22]  J. Reddy,et al.  Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator. , 1984, Biochemical and biophysical research communications.