Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

[1]  David E. Williams,et al.  Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. , 2015, Molecular nutrition & food research.

[2]  A. Kong,et al.  Nrf2 knockout enhances intestinal tumorigenesis in Apcmin/+ mice due to attenuation of anti‐oxidative stress pathway while potentiates inflammation , 2014, Molecular carcinogenesis.

[3]  Ø. Bruserud,et al.  Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents , 2013, Clinical Epigenetics.

[4]  Masayuki Yamamoto,et al.  Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. , 2013, Cancer research.

[5]  David E. Williams,et al.  HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates , 2013, Epigenetics.

[6]  Mary Goldman,et al.  The UCSC Genome Browser database: extensions and updates 2013 , 2012, Nucleic Acids Res..

[7]  Tao Chen,et al.  Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. , 2013, Topics in current chemistry.

[8]  David E. Williams,et al.  A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis , 2012, Clinical Epigenetics.

[9]  M. Sporn,et al.  NRF2 and cancer: the good, the bad and the importance of context , 2012, Nature Reviews Cancer.

[10]  J. Davie,et al.  Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors , 2012, Clinical Epigenetics.

[11]  Yuan-Xiang Pan,et al.  Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16INK4a gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet , 2012, Epigenetics.

[12]  Mary Goldman,et al.  The UCSC Genome Browser database: extensions and updates 2011 , 2011, Nucleic Acids Res..

[13]  Chun-Yin Huang,et al.  The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression , 2011, Nucleic acids research.

[14]  David E. Williams,et al.  Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells , 2011, Clinical Epigenetics.

[15]  David E. Williams,et al.  Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice , 2011, Pharmaceutical Research.

[16]  C. Löhr,et al.  NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) , 2011, International journal of cancer.

[17]  David E. Williams,et al.  Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly , 2011, Molecular Cancer.

[18]  David E. Williams,et al.  Metabolism as a key to histone deacetylase inhibition , 2011, Critical reviews in biochemistry and molecular biology.

[19]  A. Mazo,et al.  p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors , 2011, Oncogene.

[20]  Min Chen,et al.  Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A. , 2010, International journal of oncology.

[21]  M. Nagino,et al.  Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma , 2010, Cancer science.

[22]  S. Henikoff,et al.  Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model , 2010, Molecular carcinogenesis.

[23]  T. Kensler,et al.  Nrf2: friend or foe for chemoprevention? , 2010, Carcinogenesis.

[24]  R. Tuma.  Epigenetic therapies move into new territory, but how exactly do they work? , 2009, Journal of the National Cancer Institute.

[25]  Shan Zhu,et al.  The transcription factor ZBP‐89 suppresses p16 expression through a histone modification mechanism to affect cell senescence , 2009, The FEBS journal.

[26]  W-S Xu,et al.  Histone deacetylase inhibitors: Potential in cancer therapy , 2009, Journal of cellular biochemistry.

[27]  Xiuli Wang,et al.  YY1 restrained cell senescence through repressing the transcription of p16. , 2008, Biochimica et biophysica acta.

[28]  B. Delage,et al.  Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. , 2008, Carcinogenesis.

[29]  A. Kong,et al.  Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer , 2008, Cancer Prevention Research.

[30]  H. Lehr,et al.  Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice , 2008, Gut.

[31]  Masayuki Yamamoto,et al.  Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2‐deficient mice upon dextran sulfate treatment , 2007, International journal of cancer.

[32]  C. Rock,et al.  Increase in Cruciferous Vegetable Intake in Women Previously Treated for Breast Cancer Participating in a Dietary Intervention Trial , 2007, Nutrition and cancer.

[33]  E. Ho,et al.  Sulforaphane Retards the Growth of Human PC-3 Xenografts and Inhibits HDAC Activity in Human Subjects , 2007, Experimental biology and medicine.

[34]  A. Valentini,et al.  Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells , 2007, Cancer biology & therapy.

[35]  A. Kong,et al.  Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. , 2006, Cancer research.

[36]  G. Mack.  Epigenetic cancer therapy makes headway. , 2006, Journal of the National Cancer Institute.

[37]  M. Ffrench,et al.  Régulation de p16INK4a, sénescence et oncogenèse , 2006 .

[38]  A. Kong,et al.  Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. , 2006, Carcinogenesis.

[39]  Andrew J. Wilson,et al.  Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer* , 2006, Journal of Biological Chemistry.

[40]  E. Ho,et al.  Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  R. Dashwood,et al.  Chemoprotection by sulforaphane: keep one eye beyond Keap1. , 2006, Cancer letters.

[42]  E. Ho,et al.  Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? , 2006, Carcinogenesis.

[43]  M. Ffrench,et al.  [Regulation of p16INK4a, senescence and oncogenesis]. , 2006, Medecine sciences : M/S.

[44]  F. Pierre,et al.  How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. , 2005, European journal of cancer.

[45]  P. Karplus,et al.  A Novel Mechanism of Chemoprotection by Sulforaphane , 2004, Cancer Research.

[46]  P. Pandolfi,et al.  The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia , 2002, Nature Medicine.

[47]  G. Peters,et al.  Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence , 2001, Nature.

[48]  C. Rao,et al.  Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. , 2000, Carcinogenesis.

[49]  P. Nambiar,et al.  Differential Expression of p16INK4a in Azoxymethane‐Induced Mouse Colon Tumorigenesis , 2000, Molecular carcinogenesis.

[50]  J. Fahey,et al.  Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C. Cho,et al.  A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. Wargovich,et al.  Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. , 1990, Cancer research.