Neuroanatomical Phenotypes in a Mouse Model of the 22q11.2 Microdeletion

[1]  Peter J. Scambler,et al.  22q11.2 deletion syndrome. , 2015, Nature reviews. Disease primers.

[2]  S. Levy,et al.  De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia , 2012, Nature Genetics.

[3]  Jianxin Shi,et al.  Genome-wide association study of multiplex schizophrenia pedigrees. , 2012, The American journal of psychiatry.

[4]  D. Goff,et al.  Failure of neural responses to safety cues in schizophrenia. , 2012, Archives of general psychiatry.

[5]  N. Hiroi,et al.  Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain. , 2012, Human molecular genetics.

[6]  Donald A. Wilson,et al.  ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models , 2012, Science.

[7]  David R. Watson,et al.  A voxel based morphometry study investigating brain structural changes in first episode psychosis , 2012, Behavioural Brain Research.

[8]  Jeremy D. Schmahmann,et al.  Functional topography of the cerebellum for motor and cognitive tasks: An fMRI study , 2012, NeuroImage.

[9]  J. Sebat,et al.  High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia , 2011, Neuron.

[10]  Andreas Buja,et al.  Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism , 2011, Proceedings of the National Academy of Sciences.

[11]  R Mark Henkelman,et al.  Genes into geometry: imaging for mouse development in 3D. , 2011, Current opinion in genetics & development.

[12]  Jacob Ellegood,et al.  Brain abnormalities in a Neuroligin3 R451C knockin mouse model associated with autism , 2011, Autism research : official journal of the International Society for Autism Research.

[13]  J. Rapoport,et al.  Cerebellar development in childhood onset schizophrenia and non-psychotic siblings , 2011, Psychiatry Research: Neuroimaging.

[14]  M. Karayiorgou,et al.  Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion , 2011, Molecular and Cellular Neuroscience.

[15]  Ó. Vilarroya,et al.  Gray matter volume deficits and correlation with insight and negative symptoms in first‐psychotic‐episode subjects , 2011, Acta psychiatrica Scandinavica.

[16]  Bin Xu,et al.  The 22q11.2 microdeletion: Fifteen years of insights into the genetic and neural complexity of psychiatric disorders , 2011, International Journal of Developmental Neuroscience.

[17]  Jianxin Shi,et al.  Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. , 2011, The American journal of psychiatry.

[18]  B. Peterson,et al.  Mapping cortical morphology in youth with velocardiofacial (22q11.2 deletion) syndrome. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[19]  Bin Xu,et al.  Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex , 2011, Proceedings of the National Academy of Sciences.

[20]  Lindsay S. Cahill,et al.  Multiple-mouse Neuroanatomical Magnetic Resonance Imaging , 2011, Journal of visualized experiments : JoVE.

[21]  Arno Klein,et al.  A reproducible evaluation of ANTs similarity metric performance in brain image registration , 2011, NeuroImage.

[22]  Veronique D. Bohbot,et al.  Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning , 2011, NeuroImage.

[23]  T. Greenaway,et al.  22q11.2 deletion presenting with severe hypocalcaemia, seizure and basal ganglia calcification in an adult man , 2011, Internal medicine journal.

[24]  R Mark Henkelman,et al.  MRI phenotyping of genetically altered mice. , 2011, Methods in molecular biology.

[25]  Paul M. Thompson,et al.  Cerebellar grey matter deficits in first-episode schizophrenia mapped using cortical pattern matching , 2010, NeuroImage.

[26]  R. Mark Henkelman,et al.  Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging , 2010, NeuroImage.

[27]  David J. Anderson,et al.  Genetic dissection of an amygdala microcircuit that gates conditioned fear , 2010, Nature.

[28]  H. Shin,et al.  Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality , 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[29]  A. Bassett,et al.  Elevated prevalence of generalized anxiety disorder in adults with 22q11.2 deletion syndrome. , 2010, The American journal of psychiatry.

[30]  G. Pearlson,et al.  Gray-matter abnormalities in deficit schizophrenia , 2010, Schizophrenia Research.

[31]  Anders M. Dale,et al.  CORTICAL THICKNESS AND SUBCORTICAL VOLUMES IN SCHIZOPHRENIA AND BIPOLAR DISORDER , 2010, Schizophrenia Research.

[32]  Tony J. Simon,et al.  22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia , 2010, Nature Reviews Neuroscience.

[33]  P. McGuire,et al.  Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia , 2010, Biological Psychiatry.

[34]  J. Gordon,et al.  Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia , 2010, Nature.

[35]  Michael I. Miller,et al.  Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images , 2010, NeuroImage.

[36]  M. Keshavan,et al.  Evidence of gray matter reduction and dysfunction in chromosome 22q11.2 deletion syndrome , 2010, Psychiatry Research: Neuroimaging.

[37]  D. Levy,et al.  Eye tracking dysfunction in schizophrenia: characterization and pathophysiology. , 2010, Current topics in behavioral neurosciences.

[38]  J. Mukai,et al.  Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion , 2009, Neuroscience Research.

[39]  Klaus P. Ebmeier,et al.  Meta-analysis of magnetic resonance imaging studies in chromosome 22q11.2 deletion syndrome (velocardiofacial syndrome) , 2009, Schizophrenia Research.

[40]  H. Shin,et al.  Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality , 2009, Journal of Human Genetics.

[41]  Elia Formisano,et al.  Anatomical brain connectivity and positive symptoms of schizophrenia: A diffusion tensor imaging study , 2009, Psychiatry Research: Neuroimaging.

[42]  N. Bargalló,et al.  Progressive gray matter changes in first episode schizophrenia: A 4-year longitudinal magnetic resonance study using VBM , 2009, Schizophrenia Research.

[43]  Stephen Smith,et al.  Schizophrenia delays and alters maturation of the brain in adolescence. , 2009, Brain : a journal of neurology.

[44]  Klaus P. Ebmeier,et al.  Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. , 2009, The British journal of psychiatry : the journal of mental science.

[45]  T. Margrie,et al.  Sensory representations in cerebellar granule cells , 2009, Current Opinion in Neurobiology.

[46]  S. Bouix,et al.  A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala–hippocampal complex in chronic schizophrenia , 2009, Schizophrenia Research.

[47]  B. Turetsky,et al.  Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele , 2009, Neuropsychopharmacology.

[48]  Jeremy D. Schmahmann,et al.  Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies , 2009, NeuroImage.

[49]  Stephen M. Smith,et al.  Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference , 2009, NeuroImage.

[50]  John Suckling,et al.  Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia , 2008, Annals of general psychiatry.

[51]  P. Thier,et al.  The neural basis of smooth pursuit eye movements in the rhesus monkey brain , 2008, Brain and Cognition.

[52]  G. Glover,et al.  Neuroanatomical abnormalities in adolescents with attention-deficit/hyperactivity disorder. , 2008, Journal of the American Academy of Child and Adolescent Psychiatry.

[53]  Joseph A. Gogos,et al.  Palmitoylation-dependent neurodevelopmental deficits in a mouse model of the 22q11 microdeletion , 2008, Nature Neuroscience.

[54]  R. Mark Henkelman,et al.  High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice , 2008, NeuroImage.

[55]  Paul Pavlidis,et al.  Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model , 2008, Nature Genetics.

[56]  Joseph A. Gogos,et al.  Strong association of de novo copy number mutations with sporadic schizophrenia , 2008, Nature Genetics.

[57]  Hilleke E. Hulshoff Pol,et al.  Hypothalamus volume in twin pairs discordant for schizophrenia , 2008, European Neuropsychopharmacology.

[58]  A. Meyer-Lindenberg,et al.  Heritability of Brain Morphology Related to Schizophrenia: A Large-Scale Automated Magnetic Resonance Imaging Segmentation Study , 2008, Biological Psychiatry.

[59]  Brian B. Avants,et al.  Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain , 2008, Medical Image Anal..

[60]  P. Vuilleumier,et al.  Impaired Activation of Face Processing Networks Revealed by Functional Magnetic Resonance Imaging in 22q11.2 Deletion Syndrome , 2008, Biological Psychiatry.

[61]  Stefano Pini,et al.  Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia. , 2007, Schizophrenia bulletin.

[62]  Zhongle Wu,et al.  Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment. , 2007, Behavioral and brain functions : BBF.

[63]  T. Hanakawa,et al.  Impaired facial emotion recognition and reduced amygdalar volume in schizophrenia , 2007, Psychiatry Research: Neuroimaging.

[64]  Arthur W Toga,et al.  Cerebral Cortex Advance Access published October 20, 2006 Mapping Cortical Thickness in Children with 22q11.2 Deletions , 2022 .

[65]  Abraham Weizman,et al.  Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome. , 2007, The international journal of neuropsychopharmacology.

[66]  R. Henkelman,et al.  Mouse behavioral mutants have neuroimaging abnormalities , 2007, Human brain mapping.

[67]  Kenny Q. Ye,et al.  Strong Association of De Novo Copy Number Mutations with Autism , 2007, Science.

[68]  Lei Wang,et al.  Structural analysis of the basal ganglia in schizophrenia , 2007, Schizophrenia Research.

[69]  J. Gogos,et al.  Modeling Madness in Mice: One Piece at a Time , 2006, Neuron.

[70]  N. Ramnani.  The primate cortico-cerebellar system: anatomy and function , 2006, Nature Reviews Neuroscience.

[71]  Joel P. Bish,et al.  Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome , 2006, Neuroscience Letters.

[72]  R Mark Henkelman,et al.  Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography. , 2006, Physiological genomics.

[73]  K. Hugdahl,et al.  MR MORPHOMETRY ANALYSIS OF GREY MATTER VOLUME REDUCTION IN SCHIZOPHRENIA: ASSOCIATION WITH HALLUCINATIONS , 2006, The International journal of neuroscience.

[74]  B. Haubitz,et al.  Basal ganglia calcification and psychosis in 22q11.2 deletion syndrome , 2005, European Psychiatry.

[75]  Douglas W. Jones,et al.  Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[76]  James C. Gee,et al.  Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study , 2005, NeuroImage.

[77]  P. Calabresi,et al.  Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1 , 2005, Neuron.

[78]  M. Karayiorgou,et al.  NEUROPSYCHOLOGICAL CHARACTERISTICS OF CHILDREN WITH THE 22Q11 DELETION SYNDROME: A DESCRIPTIVE ANALYSIS , 2005, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[79]  Godehard Weniger,et al.  Impaired emotional learning and reduced amygdala size in schizophrenia: a 3-month follow-up , 2004, Schizophrenia Research.

[80]  Eileen Daly,et al.  Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study. , 2004, Archives of general psychiatry.

[81]  Maria Karayiorgou,et al.  Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia , 2004, Nature Genetics.

[82]  David M. Smith,et al.  Cerebellar, prefrontal cortex, and thalamic volumes over two time points in adolescent-onset schizophrenia. , 2004, The American journal of psychiatry.

[83]  Robert Turner,et al.  High‐resolution fast spin echo imaging of the human brain at 4.7 T: Implementation and sequence characteristics , 2004, Magnetic resonance in medicine.

[84]  Godfrey D. Pearlson,et al.  Frontal and Caudate Alterations in Velocardiofacial Syndrome (Deletion at Chromosome 22q11.2) , 2004, Journal of child neurology.

[85]  Robin M. Chan,et al.  An fMRI study of facial emotion processing in patients with schizophrenia. , 2002, The American journal of psychiatry.

[86]  L. Hedlund,et al.  Magnetic resonance histology for morphologic phenotyping , 2002, Journal of magnetic resonance imaging : JMRI.

[87]  Stephan Eliez,et al.  Increased basal ganglia volumes in velo-cardio-facial syndrome (deletion 22q11.2) , 2002, Biological Psychiatry.

[88]  Thomas E. Nichols,et al.  Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate , 2002, NeuroImage.

[89]  David J Mikulis,et al.  Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome , 2002, Biological Psychiatry.

[90]  J Suckling,et al.  Structural brain abnormalities associated with deletion at chromosome 22q11 , 2001, British Journal of Psychiatry.

[91]  R. McCarley,et al.  A review of MRI findings in schizophrenia , 2001, Schizophrenia Research.

[92]  Stephan Eliez,et al.  A quantitative MRI study of posterior fossa development in velocardiofacial syndrome , 2001, Biological Psychiatry.

[93]  Nancy C Andreasen,et al.  An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry , 2001, Biological Psychiatry.

[94]  Y. Eto,et al.  Morphometry of the head of the caudate nucleus in patients with velocardiofacial syndrome (del 22qll.2) , 2000, Acta paediatrica.

[95]  B. Turetsky,et al.  Reduced olfactory bulb volume in patients with schizophrenia. , 2000, The American journal of psychiatry.

[96]  S Eliez,et al.  Children and adolescents with velocardiofacial syndrome: a volumetric MRI study. , 2000, The American journal of psychiatry.

[97]  J N Giedd,et al.  MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection. , 2000, The American journal of psychiatry.

[98]  David J Mikulis,et al.  Qualitative MRI findings in adults with 22q11 deletion syndrome and schizophrenia , 1999, Biological Psychiatry.

[99]  Jurg Ott,et al.  Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder , 1999, Biological Psychiatry.

[100]  Cynthia G. Wible,et al.  Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative MRI study , 1995, Psychiatry Research: Neuroimaging.

[101]  R. Shprintzen,et al.  Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[102]  J. Lieberman,et al.  Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. , 1994, The American journal of psychiatry.

[103]  D. Collins,et al.  Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space , 1994, Journal of computer assisted tomography.

[104]  N. Baumann,et al.  Infantile form of so-called neuronal ceroid lipofuscinosis: lipid biochemical studies, fatty acid analysis of cerebroside sulfatides and sphingomyelin, myelin density profile and lipid composition. , 1979, European neurology.