Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

[1]  E. Dahl,et al.  Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. , 2008, Carcinogenesis.

[2]  T. Yeatman,et al.  Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. , 2008, Cancer research.

[3]  S. Baylin,et al.  Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer , 2008, British Journal of Cancer.

[4]  G. Kristiansen,et al.  The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation , 2008, Oncogene.

[5]  H. Sugimoto,et al.  Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma , 2007, British Journal of Cancer.

[6]  Jun Yu,et al.  Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer , 2007, British Journal of Cancer.

[7]  E. Dahl,et al.  Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma , 2007, Oncogene.

[8]  H. Fiegl,et al.  SFRP2 methylation in fecal DNA—a marker for colorectal polyps , 2007, International Journal of Colorectal Disease.

[9]  M. Toyota,et al.  Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer , 2007, Oncogene.

[10]  R. Murphy,et al.  DNA methylation in breast and colorectal cancers , 2007, Modern Pathology.

[11]  R. Dahiya,et al.  Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. , 2007, Clinical cancer research : an official journal of the American Association for Cancer Research.

[12]  Fan Yang,et al.  Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. , 2007, World journal of gastroenterology.

[13]  R. Dahiya,et al.  Wnt Antagonist Family Genes as Biomarkers for Diagnosis, Staging, and Prognosis of Renal Cell Carcinoma Using Tumor and Serum DNA , 2006, Clinical Cancer Research.

[14]  Jun Luo,et al.  Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor. , 2006, World journal of gastroenterology.

[15]  Timothy J. Yeatman,et al.  Mapping Geographic Zones of Cancer Risk with Epigenetic Biomarkers in Normal Breast Tissue , 2006, Clinical Cancer Research.

[16]  Christian Pilarsky,et al.  Molecular Profiling of Laser-Microdissected Matched Tumor and Normal Breast Tissue Identifies Karyopherin α2 as a Potential Novel Prognostic Marker in Breast Cancer , 2006, Clinical Cancer Research.

[17]  Ching-Jin Chang,et al.  Secreted Frizzled Related Protein 2 (sFRP2) Decreases Susceptibility to UV-Induced Apoptosis in Primary Culture of Canine Mammary Gland Tumors by NF-κB Activation or JNK Suppression , 2006, Breast Cancer Research and Treatment.

[18]  G. Kristiansen,et al.  Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis , 2006, Oncogene.

[19]  J. Herman,et al.  Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. , 2006, Cancer research.

[20]  A. Kaneda,et al.  High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk , 2006, Clinical Cancer Research.

[21]  J. Byrd,et al.  CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. , 2006, Cancer research.

[22]  Gary L Rosner,et al.  Tumour vasculature: On the verge of collapse , 2005, Nature Reviews Cancer.

[23]  Takayuki Fukui,et al.  Transcriptional silencing of secreted frizzled related protein 1 (SFRP1) by promoter hypermethylation in non-small-cell lung cancer , 2005, Oncogene.

[24]  D. Ahlquist,et al.  Aberrant methylation of secreted frizzled‐related protein genes in esophageal adenocarcinoma and Barrett's esophagus , 2005, International journal of cancer.

[25]  C. Marsit,et al.  Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. , 2005, Cancer research.

[26]  Biao He,et al.  Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma , 2004, Oncogene.

[27]  Peter A. Jones,et al.  Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.

[28]  D. Rimm,et al.  β‐Catenin and p53 analyses of a breast carcinoma tissue microarray , 2004, Cancer.

[29]  M. Widschwendter,et al.  Methylation changes in faecal DNA: a marker for colorectal cancer screening? , 2004, The Lancet.

[30]  Ching-Jin Chang,et al.  Autocrine/Paracrine Secreted Frizzled-related Protein 2 Induces Cellular Resistance to Apoptosis , 2004, Journal of Biological Chemistry.

[31]  Wei Dong Chen,et al.  Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer , 2004, Nature Genetics.

[32]  Szu-Ying Wu,et al.  Secreted Frizzled-related Protein 2 (SFRP2) is Highly Expressed in Canine Mammary Gland Tumors but not in Normal Mammary Glands , 2004, Breast Cancer Research and Treatment.

[33]  Jorge Cortes,et al.  Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. , 2004, Blood.

[34]  J. Herman,et al.  Gene silencing in cancer in association with promoter hypermethylation. , 2003, The New England journal of medicine.

[35]  K A Baggerly,et al.  Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. , 2003, BioTechniques.

[36]  P. Laird.  Early detection: The power and the promise of DNA methylation markers , 2003, Nature Reviews Cancer.

[37]  U. Lehmann,et al.  Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype. , 2002, Cancer research.

[38]  Long-Cheng Li,et al.  MethPrimer: designing primers for methylation PCRs , 2002, Bioinform..

[39]  C. Jomary,et al.  Secreted Frizzled-related proteins: searching for relationships and patterns. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[40]  Daiya Takai,et al.  Comprehensive analysis of CpG islands in human chromosomes 21 and 22 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[41]  P. Laird,et al.  DNA methylation analysis by MethyLight technology. , 2001, Methods.

[42]  Stuart A. Aaronson,et al.  Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow , 2001, Nature Cell Biology.

[43]  S. Sukumar,et al.  Hypermethylation of 14-3-3 σ (stratifin) is an early event in breast cancer , 2001, Oncogene.

[44]  P. Polakis.  Wnt signaling and cancer. , 2000, Genes & development.

[45]  M. Hung,et al.  β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression , 2000 .

[46]  A. Üren,et al.  Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling* , 2000, The Journal of Biological Chemistry.

[47]  A. Børresen-Dale,et al.  Re‐expression of E‐cadherin, α‐catenin and β‐catenin, but not of γ‐catenin, in metastatic tissue from breast cancer patients , 2000 .

[48]  J. Minna,et al.  Comparison of features of human breast cancer cell lines and their corresponding tumors. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[49]  J. Herman,et al.  Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Herman,et al.  E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. , 1995, Cancer research.

[51]  J. Herman,et al.  Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. , 1995, Cancer research.

[52]  S. Baylin,et al.  Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. , 1994, Cancer research.

[53]  Jiri Bartek,et al.  Cyclin D1 protein expression and function in human breast cancer , 1994, International journal of cancer.

[54]  I. Ellis,et al.  Method for grading breast cancer. , 1993, Journal of clinical pathology.

[55]  R. Sager.  Tumor suppressor genes: the puzzle and the promise. , 1989, Science.

[56]  W. Remmele,et al.  [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]. , 1987, Der Pathologe.

[57]  J. Herman,et al.  Methylation-specific polymerase chain reaction. , 2005, Methods in molecular medicine.

[58]  M. Esteller.  Aberrant DNA methylation as a cancer-inducing mechanism. , 2005, Annual review of pharmacology and toxicology.

[59]  C. Osborne,et al.  Biological differences among MCF-7 human breast cancer cell lines from different laboratories , 2005, Breast Cancer Research and Treatment.

[60]  Matty P. Weijenberg,et al.  A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer , 2002, Nature Genetics.

[61]  S. Sukumar,et al.  Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. , 2001, Oncogene.

[62]  Masafumi Nakamura,et al.  Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC , 2001, Nature Cell Biology.

[63]  M. Hung,et al.  Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[64]  F. McCormick,et al.  Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. , 1999, Nature.