Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

[1]  G. Perkins,et al.  Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial , 2012, Trials.

[2]  Oliver Soehnlein,et al.  Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation , 2012, PloS one.

[3]  P. Åkesson,et al.  Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock , 2012, Critical Care.

[4]  H. Herwald,et al.  Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study , 2011, Inflammation Research.

[5]  H. Herwald,et al.  Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[6]  D. McAuley,et al.  A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study). , 2011, American journal of respiratory and critical care medicine.

[7]  J. Backman,et al.  Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. , 2009, American journal of respiratory and critical care medicine.

[8]  Keishi Kubo,et al.  Acute lung injury review. , 2009, Internal medicine.

[9]  O. Soehnlein,et al.  Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. , 2008, The Journal of clinical investigation.

[10]  A. Zernecke,et al.  Neutrophil secretion products pave the way for inflammatory monocytes. , 2008, Blood.

[11]  D. Grigoryev,et al.  Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[12]  M. Wolzt,et al.  Simvastatin Blunts Endotoxin-Induced Tissue Factor In Vivo , 2005, Circulation.

[13]  J. Nick,et al.  A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense. , 2005, American journal of respiratory and critical care medicine.

[14]  L. Björck,et al.  M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage , 2004, Cell.

[15]  H. Herwald,et al.  Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. , 2002, Blood.

[16]  L. Iversen,et al.  Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability , 2001, Nature Medicine.

[17]  Joerg Kallen,et al.  Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site , 2001, Nature Medicine.

[18]  T. Evans,et al.  Pulmonary endothelial permeability in patients with severe lung injury. Clinical correlates and natural history. , 1994, Chest.

[19]  K. Steinberg,et al.  Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. , 1994, American journal of respiratory and critical care medicine.

[20]  M. Diamond,et al.  Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils. , 1993, The Journal of clinical investigation.

[21]  M. Diamond,et al.  A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen , 1993, The Journal of cell biology.

[22]  W. Shafer,et al.  Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate , 1984, Infection and immunity.