Immune function in X-linked retinoschisis (XLRS) subjects in an AAV8-RS1 Phase I/IIa gene therapy trial.

[1]  E. Rodríguez-Bocanegra,et al.  Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety , 2020, Progress in Retinal and Eye Research.

[2]  P. Sieving,et al.  Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1−/y) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery , 2020, Human gene therapy.

[3]  Ji Min Kim,et al.  rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects , 2020, Cancers.

[4]  Yihua Zhu,et al.  The effect of human gene therapy for RPE65-associated Leber’s congenital amaurosis on visual function: a systematic review and meta-analysis , 2020, Orphanet Journal of Rare Diseases.

[5]  F. Mingozzi,et al.  AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

[6]  Namita Dave,et al.  Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis , 2019, Ocular immunology and inflammation.

[7]  F. Pérez-Cano,et al.  Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats , 2019, Nutrients.

[8]  G. Ye,et al.  Ocular inflammatory response to intravitreal injection of AAV vector: relative contribution of genome and capsid. , 2019, Human gene therapy.

[9]  Yan Ding,et al.  The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review , 2019, Front. Immunol..

[10]  J. Sahel,et al.  Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial , 2019, JAMA ophthalmology.

[11]  C. Cepko,et al.  AAV cis-regulatory sequences are correlated with ocular toxicity , 2019, Proceedings of the National Academy of Sciences.

[12]  I. MacDonald,et al.  Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience. , 2018, American journal of ophthalmology.

[13]  P. Sieving,et al.  Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  Fengna Chu,et al.  The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis , 2018, Journal of Neuroimmunology.

[15]  Ji Min Kim,et al.  Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice , 2018, BioMed research international.

[16]  B. Wilhelm,et al.  AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[17]  W. Hauswirth,et al.  Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-Mutant Dogs. , 2017, Human gene therapy. Clinical development.

[18]  G. Aguirre,et al.  Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration , 2017, Scientific Reports.

[19]  R. Striker,et al.  Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? , 2017, PLoS pathogens.

[20]  B. Wilhelm,et al.  Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates. , 2017, Investigative ophthalmology & visual science.

[21]  T. Aleman,et al.  Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina. , 2017, Human gene therapy.

[22]  T. Radstake,et al.  Systemic inflammatory immune signatures in a patient with CRB1 linked retinal dystrophy , 2016, Expert review of clinical immunology.

[23]  Jing-Pian Peng,et al.  The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse , 2016, Scientific Reports.

[24]  C. Chen,et al.  Efficacy and Safety of rAAV2-ND4 Treatment for Leber’s Hereditary Optic Neuropathy , 2016, Scientific Reports.

[25]  W. Hauswirth,et al.  Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial , 2016, Human Genetics.

[26]  A. J. Roman,et al.  Improvement and decline in vision with gene therapy in childhood blindness. , 2015, The New England journal of medicine.

[27]  S. E. Barker,et al.  Long-term effect of gene therapy on Leber's congenital amaurosis. , 2015, The New England journal of medicine.

[28]  J. Sahel,et al.  Gene therapy for inherited retinal degenerations. , 2014, Comptes rendus biologies.

[29]  D. Petrovič,et al.  A Flow Cytometric Analysis of Vitreous Inflammatory Cells in Patients with Proliferative Diabetic Retinopathy , 2013, BioMed research international.

[30]  J. Bennett,et al.  Immunology of AAV-Mediated Gene Transfer in the Eye , 2013, Front. Immunol..

[31]  Kejian Zhang,et al.  Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis , 2013, Front. Immunol..

[32]  C. R. Abernathy,et al.  Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa. , 2013, Human gene therapy. Clinical development.

[33]  Alexander Sumaroka,et al.  Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement , 2013, Proceedings of the National Academy of Sciences.

[34]  Pratima Chowdary,et al.  Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. , 2011, The New England journal of medicine.

[35]  James M. Wilson,et al.  Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver. , 2011, Gastroenterology.

[36]  Michael J. Castle,et al.  Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey , 2011, Science Translational Medicine.

[37]  H. Kazazian,et al.  Efficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  M. Colonna,et al.  Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. , 2010, Immunity.

[39]  Hongmei Li,et al.  CD11c+CD11b+ Dendritic Cells Play an Important Role in Intravenous Tolerance and the Suppression of Experimental Autoimmune Encephalomyelitis1 , 2008, The Journal of Immunology.

[40]  Kathleen A. Marshall,et al.  Safety and efficacy of gene transfer for Leber's congenital amaurosis. , 2008, The New England journal of medicine.

[41]  T. Flotte,et al.  Clinical gene therapy using recombinant adeno-associated virus vectors , 2008, Gene Therapy.

[42]  P. Sieving,et al.  Retinoschisin gene therapy and natural history in the Rs1h-KO mouse: long-term rescue from retinal degeneration. , 2007, Investigative ophthalmology & visual science.

[43]  K. Suk,et al.  Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis. , 2007, Immunology letters.

[44]  Marcela V Maus,et al.  CD8+ T-cell responses to adeno-associated virus capsid in humans , 2007, Nature Medicine.

[45]  J. Rasko,et al.  Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response , 2006, Nature Medicine.

[46]  Douglas A Jabs,et al.  Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. , 2005, American journal of ophthalmology.

[47]  A. Franke,et al.  Lymphocyte subsets' reference ranges in an age- and gender-balanced population of 100 healthy adults--a monocentric German study. , 2005, Clinical immunology.

[48]  P. Stenvinkel,et al.  IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. , 2005, Kidney international.

[49]  A. Tzankov,et al.  Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes , 2005, Immunology.

[50]  N. Bhardwaj,et al.  Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity , 2005, Journal of Virology.

[51]  T. Flotte.  Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy. , 2001, Current opinion in molecular therapeutics.

[52]  V. Kostulas,et al.  Two subsets of dendritic cells are present in human cerebrospinal fluid. , 2001, Brain : a journal of neurology.

[53]  M. Kaiser-Kupfer,et al.  Immune response to retinal antigens in patients with gyrate atrophy and other hereditary retinal dystrophies , 2001, Ocular immunology and inflammation.

[54]  J. Heckenlively,et al.  Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa. , 1999, American journal of ophthalmology.

[55]  J. Bennett,et al.  Humoral response after administration of E1-deleted adenoviruses: immune privilege of the subretinal space. , 1996, Human gene therapy.

[56]  G. Danieli,et al.  Genetic control of the CD4/CD8 T-cell ratio in humans , 1995, Nature Medicine.

[57]  S. Kaaba,et al.  Abnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives. , 1995, Immunology letters.

[58]  C. Brodie,et al.  T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease. , 1995, Clinical immunology and immunopathology.

[59]  H. Friedman,et al.  Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients , 1995, Clinical and Diagnostic Laboratory Immunology.

[60]  A. Fattorossi,et al.  Peripheral T-cell subset imbalance in patients with vitiligo and in their apparently healthy first-degree relatives. , 1990, Annals of allergy.

[61]  F. Arnett,et al.  Familial abnormalities of lymphocyte function in a large Sjögren's syndrome kindred. , 1986, The Journal of rheumatology.

[62]  J. H. Koch,et al.  Immunosuppressive activity of submaxillary gland extracts of the mouse 1. Effect on antibody formation in response to sheep red blood cells , 1976, European journal of immunology.

[63]  M. Evans,et al.  Age- and Race-Related Changes in Subpopulations of Peripheral Blood Lymphocytes in Humans , 2019, Handbook of Immunosenescence.

[64]  A. Gerber,et al.  Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle. , 2019, American journal of physiology. Lung cellular and molecular physiology.

[65]  K. Verhoeckx,et al.  The Impact of Food Bioactives on Health , 2015, Springer International Publishing.

[66]  Y. Murakami,et al.  Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa. , 2013, Ophthalmology.

[67]  R. Herzog,et al.  Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia. , 2012, Journal of genetic syndromes & gene therapy.

[68]  N. Kadowaki.  The divergence and interplay between pDC and mDC in humans. , 2009, Frontiers in bioscience.

[69]  Christopher B Wilson,et al.  Regulation of interferon-gamma during innate and adaptive immune responses. , 2007, Advances in immunology.

[70]  R. Nussenblatt,et al.  Cellular immune responses to retinal antigens in retinitis pigmentosa , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[71]  J. Lamb,et al.  Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines. , 1985, Immunology.

[72]  T. Fifis,et al.  Molecular species of epidermal growth factor carrying immunosuppressive activity , 1984, Journal of cellular biochemistry.